A multifaceted intervention to improve sepsis management in general hospital wards with evaluation using segmented regression of interrupted time series

BMJ Quality and Safety

Volumn 23, Issue 12, 2014, Pages e2-

  Marwick, Charis A ^a   Guthrie, Bruce ^a   Pringle, Jan E C ^b   Evans, Josie M M ^c   Nathwani, Dilip ^d   Donnan, Peter T ^a   Davey, Peter G ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b GLASGOW CALEDONIAN UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF STIRLING   (United Kingdom)

^d NINEWELLS HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; LACTIC ACID; ANTIINFECTIVE AGENT;

ABDOMINAL INFECTION; AGED; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; CATHETER INFECTION; CLINICAL FEATURE; CLOSTRIDIUM DIFFICILE INFECTION; FEEDBACK SYSTEM; FEMALE; GENERAL HOSPITAL; HEALTH CARE QUALITY; HUMAN; LACTATE BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MEDICAL AUDIT; OUTCOME ASSESSMENT; PATIENT SAFETY; PRACTICE GUIDELINE; PREDICTIVE VALUE; REGRESSION ANALYSIS; RESPIRATORY TRACT INFECTION; SEPSIS; SKIN INFECTION; SOFT TISSUE INFECTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TEACHING HOSPITAL; TIME SERIES ANALYSIS; TOTAL QUALITY MANAGEMENT; UNITED KINGDOM; URINARY TRACT INFECTION; DISEASE MANAGEMENT; EPIDEMIOLOGY; HEALTH CARE FACILITY; HOSPITAL PATIENT; INTERVIEW; QUESTIONNAIRE; SCOTLAND; TREATMENT OUTCOME;

ANTI-BACTERIAL AGENTS; DISEASE MANAGEMENT; FEEDBACK; HOSPITALS, TEACHING; HUMANS; INPATIENTS; INTERRUPTED TIME SERIES ANALYSIS; INTERVIEWS AS TOPIC; OUTCOME AND PROCESS ASSESSMENT (HEALTH CARE); PATIENTS' ROOMS; QUALITY IMPROVEMENT; SCOTLAND; SEPSIS; SURVEYS AND QUESTIONNAIRES;

EID: 84893656298     PISSN: 20445415     EISSN: None     Source Type: Journal    
DOI: 10.1136/bmjqs-2013-002176     Document Type: Article

References (33)

1. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006;34:1589-96.
2. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001;345:1368-77.
3. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008;36:296-327.
4. Surviving Sepsis Campaign. Severe sepsis bundles. Surviving Sepsis Campaign, 2006.
5. Nguyen HB, Corbett SW, Steele R, et al. Implementation of a bundle of quality indicators for the early management of severe sepsis and septic shock is associated with decreased mortality. Crit Care Med 2007;35:1105-12.
6. Marwick C, Watts E, Evans J, et al. Quality of care in sepsis management: development and testing of measures for improvement. J Antimicrob Chemother 2007;60:694-7.
7. Scottish Patient Safety Programme. Healthcare Improvement Scotland and NHS Education for Scotland.
8. Levy MM, Fink MP, Marshall JC, et al. 2001 SCCM/ESICM/ ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 2003;31:1250-6.
9. The Institute for Healthcare Improvement. Cambridge MA: IHI Knowledge Centre, 2012. http://www.ihi.org/knowledge/Pages/ HowtoImprove/default.aspx
10. Houck PM, Bratzler DW, NsaW, et al. Timing of antibiotic administration and outcomes for Medicare patients hospitalized with community-acquired pneumonia. Arch Intern Med 2004;164:637-44.
11. Meehan TP, Fine MJ, Krumholz HM, et al. Quality of care, process, and outcomes in elderly patients with pneumonia. Jama 1997;278:2080-4.
12. Paterson R, MacLeod DC, Thetford D, et al. Prediction of in-hospital mortality and length of stay using an early warning scoring system: clinical audit.[see comment]. Clin Med 2006;6:281-4.
13. Urbaniak G, Plous S. Research Randomizer: Social Psychology Network, 1997: Random set generator.
14. Medical Research Council. Developing and evaluating complex interventions: new guidance. MRC, 2008.
15. Daniels R, Nutbeam T,McNamara G, et al. The sepsis six and the severe sepsis resuscitation bundle: a prospective observational cohort study. Emerg Med J 2011;28:507-12.
16. Perla RJ, Provost LP, Murray SK. The run chart: a simple analytical tool for learning from variation in healthcare processes. BMJ Qual Saf Healthcare 2011(20):46-51.
17. Wagner AK, Soumerai SB, Zhang F, et al. Segmented regression analysis of interrupted time series studies in medication use research. J Clin Pharm Ther 2002;27:299-309.
18. Durbin J, Watson GS. Testing for serial correlation in least squares regression. I. Biometrika 1950;37:409-28.
19. Godfrey LG, Wickens MR. Testing Linear and Log-Linear Regressions for Functional Form. Revi Econ Stud 1981; XLVIII:487-96.
20. Akaike H. A new look at the statistical model identification. Automatic Cont IEEE Trans 1974;19:716-23.
21. Berenholtz SM, Needham DM, Lubomski LH, et al. Improving the quality of quality improvement projects. Jt Comm J Qual Patient Saf 2010;36:468-73.
22. Sinuff T, Muscedere J, Cook DJ, et al. Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study. Crit Care Med 2013;41:15-23.
23. Li Bassi G, Ranzani OT, Torres A. Systematic implementation of evidence-based guidelines in intensive care medicine: resistance to change is human nature. Crit Care Med 2013;41:329-31.
24. Ogrinc G, Mooney SE, Estrada C, et al. The SQUIRE (Standards for QUality Improvement Reporting Excellence) guidelines for quality improvement reporting: explanation and elaboration. Qual Saf Health Care 2008;17(Suppl 1):i13-32.
25. Barlow G, Nathwani D, Williams F, et al. Reducing door-to-antibiotic time in community-acquired pneumonia: Controlled before-and-after evaluation and cost-effectiveness analysis. Thorax 2007;62:67-74.
26. Charani E, Castro-Sanchez E, Sevdalis N, et al. Understanding the Determinants of Antimicrobial Prescribing within hospitals: The role of 'Prescribing Etiquette'. Clin Infect Dis 2013; 57:188-96.
27. Cabana MD, Rand CS, Powe NR, et al. Why Don't Physicians Follow Clinical Practice Guidelines? A Framework for Improvement. JAMA 1999;282:1458-65.
28. Hulscher MEJL, Grol RPTM, van der Meer JWM. Antibiotic prescribing in hospitals: a social and behavioural scientific approach. Lancet Infect Dis 2010;10:167-75.
29. Gardner B, Whittington C, McAteer J, et al. Using theory to synthesise evidence from behaviour change interventions: the example of audit and feedback. Soc Sci Med 2010;70: 1618-25.
30. Hysong SJ. Meta-analysis: audit and feedback features impact effectiveness on care quality. Med Care 2009;47:356-63.
31. Ivers N, Jamtvedt G, Flottorp S, et al. Audit and feedback: effects on professional practice and healthcare outcomes. Cochrane Database Syst Rev 2012;6:CD000259.
32. Nelson EC, Splaine ME, Batalden PB, et al. Building measurement and data collection into medical practice. Ann Intern Med 1998;128:460-6.
33. NHS Education for Scotland. Sepsis and VTE: NHS Education for Scotland, 2012.