Comparative pharmacokinetics and brain distribution of magnolol and honokiol after oral administration of Magnolia officinalis cortex extract and its compatibility with other herbal medicines in Zhi-Zi-Hou-Po Decoction to rats

Biomedical Chromatography

Volumn 30, Issue 3, 2016, Pages 369-375

  Liu, Yuan ^a   Wang, Dan ^a   Yang, Gongjun ^a   Shi, Qingshui ^b   Feng, Fang ^a  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Institute for Food and Drug Control   (China)

Author keywords

Brain distribution; Honokiol; HPLC FLD; Magnolol; Pharmacodynamics

Indexed keywords

MEDICINE; PLANT EXTRACTS;

ACTIVE INGREDIENTS; BRAIN DISTRIBUTION; CITRUS AURANTIUM L.; CORTEXES; HERBAL MEDICINES; HONOKIOL; HPLC-FLD; MAGNOLOL; ORAL ADMINISTRATION; THERAPEUTIC EFFECTS;

PHARMACOKINETICS;

HERBACEOUS AGENT; HONOKIOL; MAGNOLIA OFFICINALIS EXTRACT; MAGNOLOL; UNCLASSIFIED DRUG; ZHI ZI HOU PO DECOCTION; BIPHENYL DERIVATIVE; IRIDOID; LIGNAN; PLANT EXTRACT; ZHI-ZI-HOU-PU DECOCTION;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BRAIN CORTEX; CALIBRATION; CEREBELLUM; CORPUS STRIATUM; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; HYPOTHALAMUS; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAGNOLIA OFFICINALIS; MALE; MEAN RESIDENCE TIME; MEASUREMENT ACCURACY; NONHUMAN; PHARMACOKINETIC PARAMETERS; RAT; ANIMAL; BRAIN CHEMISTRY; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; MAGNOLIA; ORAL DRUG ADMINISTRATION; TISSUE DISTRIBUTION;

ADMINISTRATION, ORAL; ANIMALS; BIPHENYL COMPOUNDS; BRAIN CHEMISTRY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; DRUGS, CHINESE HERBAL; IRIDOIDS; LIGNANS; MAGNOLIA; MALE; PLANT EXTRACTS; RATS; TISSUE DISTRIBUTION;

EID: 84956583994     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.3557     Document Type: Article

References (20)

1. Ding GY. Quality standard, pharmacokinetics and tissue distribution studies of Magnolia officinalis raw products and processed products. Liaoning University of Chinese Medicine (China), 2011.
2. Han M, Yu X, Guo Y, Wang Y, Kuang H and Wang X. Honokiol nanosuspensions: Preparation, increased oral bioavaliability and dramatically enhanced biodistribution in thecardio-cerebro-vascular system. Colloids and Surfaces B: Biointerfaces 2014; 116: 114-120.
3. Hattori M, Endo Y, Takebe S, Kobashi K, Fukasaku N and Namba T. Metabolism of magnolol from Magnoliae cortex. II. Absorption, metabolism and excretion of [ring-14C]magnolol in rats. Chemical and Pharmaceutical Bulletin 1986; 34: 158-167.
4. Li LF, Lu J, Li XM, Xu CL, Deng JM, Qu R and Ma SP. Antidepressant-like effect of magnolol on BDNF up-regulation and serotonergic system activity in unpredictable chronic mild stress treated rats. Phytotherapy Research 2012; 26: 1189-1194.
5. Li LF, Yang J, Ma SP and Qu R. Magnolol treatment reversed the glial pathology in an unpredictable chronic mild stress-induced rat model of depression. European Journal of Pharmacology 2013; 711: 42-49.
6. Lin SP, Tsai SY, Lee Chao PD, Chen YC and Hou YC. Pharmacokinetics, bioavailability, and tissue distribution of magnolol following single and repeated dosing of magnolol to rats. Planta Medica 2011; 77: 1800-1805.
7. Paxinos G and Watson C., 6th edn, The Rat Brain in Stereotaxic Coordinates. Academic Press: London, 2007.
8. Qiang LQ, Wang CP, Wang FM, Pan Y, Yi LT, Zhang X and Kong LD. Combined administration of the mixture of honokiol and magnolol and ginger oil evokes antidepressant-like synergism in rats. Archives of Pharmacal Research 2009; 32: 1281-1292.
9. Qu XS, Yang YF, Zhang J, Hu X and Luo YM. Different extraction methods and antidepressant spectrum-effect relationship of Zhi-Zi-Hou-Po decoction. Chinese Journal of Pharmaceuticals 2014; 45: 424-428.
10. Reagan-Shaw S, Nihal M and Ahmad N. Dose translation from animal to human studies revisited. Faseb Journal 2008; 22: 659-661.
11. Sheng YL, Xu JH, Shi CH, Li W, Xu HY, Li N, Zhao YQ and Hang XR. UPLC-MS/MS-ESI assay for simultaneous determination of magnolol and honokiol in rat plasma: Application to pharmacokinetic study after administration emulsion of the isomer. Journal of Ethnopharmacolog 2014; 155: 1568-1574.
12. Sun YQ, Ma FF, Zhu J and Feng F. Fingerprints and quantitative analysis of multi-index of Zhi-Zi-Hou-Po decoction, related herb couple and single herb. Progress in Pharmaceutical Sciences 2011; 35: 373-378.
13. Tsai TH, Chou CJ and Chen CF. Pharmacokinetics and brain distribution of magnolol in the rat after intravenous bolus injection. Journal of Pharmacy and Pharmacology 1996; 48: 57-59.
14. Wu XN, Chen XG and Hu ZD. High-performance liquid chromatographic method for simultaneous determination of honokiol and magnolol in rat plasma. Talanta 2003; 59: 115-121.
15. Xu FG, Liu Y, Zhang ZJ, Song R, Dong HJ and Tian Y. Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction. Journal of Pharmaceutical and Biomedical Analysis 2008; 47: 586-595.
16. Xu Q, Yi LT, Pan Y, Wang X, Li YC, Li JM, Wang CP and Kong LD. Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents. Progress in Neuro-psychopharmacology and Biological Psychiatry 2008; 32: 715-725.
17. Yan Y, Feng F and Wang D. Antidepressant actives of Zhi-Zi-Hou-Po decoction. Progress in Pharmaceutical Sciences 2010; 34: 275-280.
18. Yao AM, Ma FF, Zhang LL and Feng F. Effect of aqueous extract and fractions of Zhi-Zi-Hou-Pu decoction against depression in inescapable stressed mice: Restoration of monoamine neurotransmitters in discrete brain regions. Pharmaceutical Biology 2013; 51: 213-220.
19. Yi LT, Xu Q, Li YC, Yang L and Kong LD. Antidepressant-like synergism of extracts from magnolia bark and ginger rhizome alone and in combination in mice. Progress in Neuro-psychopharmacology and Biological Psychiatry 2009; 33: 616-624.
20. Yuan C, Liang AJ, Zeng L, Jia N and Feng L. Pharmacokinetics of magnolol and honokiol in rats. Pharmaceutical Journal of Chinese People's Liberation Army 2003; 19: 258-261.