High expression of matrix metalloproteinases: MMP-2 and MMP-9 predicts poor survival outcome in colorectal carcinoma

Future Oncology

Volumn 12, Issue 3, 2016, Pages 323-331

  Salem, Nada ^a   Kamal, Ibrahim ^a   Al Maghrabi, Jaudah ^b   Abuzenadah, Adel ^a   Peer Zada, Abdul Ali ^c   Qari, Yousif ^b   Al Ahwal, Mahmoud ^b   Al Qahtani, Mohammed ^a   Buhmeida, Abdelbaset ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b King Abdulaziz University   (Saudi Arabia)

^c KING FAHAD MEDICAL CITY   (Saudi Arabia)

Author keywords

CRC; IHC; MMPs; prognosis

Indexed keywords

GELATINASE A; GELATINASE B; MATRILYSIN; MMP2 PROTEIN, HUMAN; MMP9 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; COLORECTAL CARCINOMA; CORRELATIONAL STUDY; DISEASE FREE SURVIVAL; DISEASE SPECIFIC SURVIVAL; FEMALE; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INVESTIGATIVE PROCEDURES; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL RATE; COLORECTAL TUMOR; ENZYMOLOGY; KAPLAN MEIER METHOD; METABOLISM; MIDDLE AGED; MORTALITY; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; TUMOR RECURRENCE;

COLORECTAL NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; KAPLAN-MEIER ESTIMATE; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; PROGNOSIS; PROPORTIONAL HAZARDS MODELS;

EID: 84956553951     PISSN: 14796694     EISSN: 17448301     Source Type: Journal    
DOI: 10.2217/fon.15.325     Document Type: Article

References (26)

1. Gingras D, Beliveau R. Colorectal cancer prevention through dietary and lifestyle modifications. Cancer Microenviron. 4(2), 133-139 (2011
2. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN 2012 v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11, 2014 (2013
3. Puppa G, Sonzogni A, Colombari R, Pelosi G. TNM staging system of colorectal carcinoma: a critical appraisal of challenging issues. Arch. Pathol. Lab. Med. 134(6), 837-852 (2010
4. Ross JS, Torres-Mora J, Wagle N, Jennings TA, Jones DM. Biomarker-based prediction of response to therapy for colorectal cancer: current perspective. Am. J. Clin. Pathol. 134(3), 478-490 (2010
5. Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141(1), 52-67 (2010
6. Kermorgant S, Aparicio T, Dessirier V, Lewin MJ, Lehy T. Hepatocyte growth factor induces colonic cancer cell invasiveness via enhanced motility and protease overproduction. Evidence for PI3 kinase and PKC involvement. Carcinogenesis 22(7), 1035-1042 (2001
7. Koskensalo S, Louhimo J, Nordling S, Hagstrom J, Haglund C. MMP-7 as a prognostic marker in colorectal cancer. Tumour Biol. 32(2), 259-264 (2011
8. Koskensalo S, Hagstrom J, Linder N, et al. Lack of MMP-9 expression is a marker for poor prognosis in Dukes' B colorectal cancer. BMC Clin. Pathol. 12, 24 (2012
9. Hong SW, Kang YK, Lee B, et al. Matrix metalloproteinase-2 and -7 expression in colorectal cancer. J. Korean Soc. Coloproctol. 27(3), 133-139 (2011
10. Cho YB, Lee WY, Song SY, Shin HJ, Yun SH, Chun H-K. Matrix metalloproteinase-9 activity is associated with poor prognosis in T3-T4 node-negative colorectal cancer. Hum. Pathol. 38(11), 1603-1610 (2007
11. Šundov Ž, Tomiæ S, Viloviæ K, Kunac N, Kalebiæ M, Beziæ J. Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Duke's B colon cancer. Croat. Med. J. 49(5), 636-642 (2008
12. Lipponen P, Collan Y. Simple quantitation of immunohistochemical staining positivity in microscopy. Acta Stereol. (11), 125-132 (1992
13. Saudi Arabia Cancer Incidence and Survival Report in Saudi Arabia 2007. http://ghdx.healthdata.org
14. Huh JW, Kim HR, Kim YJ, et al. Expression of standard CD44 in human colorectal carcinoma: association with prognosis. Pathol. Int. 59(4), 241-246 (2009
15. Lyall MS, Dundas SR, Curran S, Murray GI. Profiling markers of prognosis in colorectal cancer. Clin. Cancer Res. 12(4), 1184-1191 (2006
16. Hilska M, Roberts PJ, Collan YU, et al. Prognostic significance of matrix metalloproteinases-1, -2, -7 and -13 and tissue inhibitors of metalloproteinases-1, -2, -3 and -4 in colorectal cancer. Int. J.Cancer 121(4), 714-723 (2007
17. Zhou ZG, Wu XJ, Li LR, et al. A multivariate analysis of prognostic determinants for stages II and III colorectal cancer in 141 patients. Chin. Med. J. (Engl). 124(14), 2132-2135 (2011
18. Sis B, Sagol O, Kupelioglu A, et al. Prognostic significance of matrix metalloproteinase-2, cathepsin D, and tenascin-C expression in colorectal carcinoma. Pathol. Res. Pract. 200(5), 379-387 (2004
19. Bendardaf R, Buhmeida A, Hilska M, et al. MMP-9 (gelatinase B) expression is associated with disease-free survival and disease-specific survival in colorectal cancer patients. Cancer Invest. 28(1), 38-43 (2010
20. Chu D, Zhao Z, Zhou Y, et al. Matrix metalloproteinase-9 is associated with relapse and prognosis of patients with colorectal cancer. Ann. Surg. Oncol. 19(1), 318-325 (2012
21. Dragutinovic VV, Radonjic NV, Petronijevic ND, et al. Matrix metalloproteinase-2 (MMP-2) and -9 (MMP-9) in preoperative serum as independent prognostic markers in patients with colorectal cancer. Mol. Cell. Biochem. 355(1-2), 173-178 (2011
22. Sun DW, Zhang YY, Qi Y, Zhou XT, Lv GY. Prognostic significance of MMP-7 expression in colorectal cancer: a meta-analysis. Cancer Epidemiol. 39(2), 135-142 (2015
23. Kostova E, Slaninka-Miceska M, Labacevski N, et al. Expression of matrix metalloproteinases 2, 7 and 9 in patients with colorectal cancer. Vojnosanit. Pregl. 71(1), 52-59 (2014
24. Bellmunt J, Werner L, Bamias A, et al. HER2 as a target in invasive urothelial carcinoma. Cancer Med. 4(6), 844-852 (2015
25. Buhmeida A, Bendardaf R, Hilska M, et al. Prognostic significance of matrix metalloproteinase-9 (MMP-9) in stage II colorectal carcinoma. J. Gastrointest. Cancer 40(3-4), 91-97 (2009
26. Kim TD, Song KS, Li G, et al. Activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer. BMC Cancer 6, 211 (2006