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Volumn 16, Issue 1, 2016, Pages 10-13

Incretins, diabetes, pancreatitis and pancreatic cancer: What the GI specialist needs to know

Author keywords

[No Author keywords available]

Indexed keywords

DIPEPTIDYL PEPTIDASE IV INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; INCRETIN; METFORMIN; ANTIDIABETIC AGENT;

EID: 84956541198     PISSN: 14243903     EISSN: 14243911     Source Type: Journal    
DOI: 10.1016/j.pan.2015.11.009     Document Type: Review
Times cited : (26)

References (42)
  • 2
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acutepancreatitis and biliary disease observed in patients with type 2 diabetes: Aretrospective cohort study
    • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acutepancreatitis and biliary disease observed in patients with type 2 diabetes: aretrospective cohort study. Diabetes Care 2009;32:834-8.
    • (2009) Diabetes Care , vol.32 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 3
    • 80052497887 scopus 로고    scopus 로고
    • Risk of acute pancreatitis in type 2diabetes and risk reduction on anti-diabetic drugs: A population-based cohortstudy in Taiwan
    • Lai SW, Muo CH, Liao KE, Sung FC, Chen PC. Risk of acute pancreatitis in type 2diabetes and risk reduction on anti-diabetic drugs: a population-based cohortstudy in Taiwan. Am J Gastroenterol 2011;106:1697-704.
    • (2011) Am J Gastroenterol , vol.106 , pp. 1697-1704
    • Lai, S.W.1    Muo, C.H.2    Liao, K.E.3    Sung, F.C.4    Chen, P.C.5
  • 4
    • 77955016889 scopus 로고    scopus 로고
    • Patients with type 2 diabetes mellitus have higher risk for acutepancreatitis compared to those without diabetes
    • Girman CJ, Kou TD, Cai B, Alexander CM, O'Neill EA, Williams-Herman DE,et al. Patients with type 2 diabetes mellitus have higher risk for acutepancreatitis compared to those without diabetes. Diabetes Obes Metab2010;12:766-71.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 766-771
    • Girman, C.J.1    Kou, T.D.2    Cai, B.3    Alexander, C.M.4    O'Neill, E.A.5    Williams-Herman, D.E.6
  • 5
    • 84867221155 scopus 로고    scopus 로고
    • Increased risk of severe acutepancreatitis in patients with diabetes
    • Shen HN, Chang YH, Chen HF, Lu CL, Li CY. Increased risk of severe acutepancreatitis in patients with diabetes. Diabet Med 2012;29:1419-24.
    • (2012) Diabet Med , vol.29 , pp. 1419-1424
    • Shen, H.N.1    Chang, Y.H.2    Chen, H.F.3    Lu, C.L.4    Li, C.Y.5
  • 6
    • 84872065294 scopus 로고    scopus 로고
    • Type 2 diabetes mellitus and the risk of acutepancreatitis
    • Yang L, He Z, Tang X, Liu J. Type 2 diabetes mellitus and the risk of acutepancreatitis. Eur J Gastro 2013;25:225-31.
    • (2013) Eur J Gastro , vol.25 , pp. 225-231
    • Yang, L.1    He, Z.2    Tang, X.3    Liu, J.4
  • 7
    • 84862099251 scopus 로고    scopus 로고
    • Effect of diabetes on severity and hospital mortality inpatients with acute pancreatitis: A national population-based study
    • Shen HN, Lu CL, Li CY. Effect of diabetes on severity and hospital mortality inpatients with acute pancreatitis: a national population-based study. DiabetesCare 2012;35:1061-6.
    • (2012) Diabetes Care , vol.35 , pp. 1061-1066
    • Shen, H.N.1    Lu, C.L.2    Li, C.Y.3
  • 8
    • 84872341897 scopus 로고    scopus 로고
    • Increased variability and abnormalitiesn pancreatic enzyme concentrations in otherwise asymptomaticsubjects with type 2 diabetes
    • Malloy J, Gurney K, Shan K, Yan P, Chen S. Increased variability and abnormalitiesn pancreatic enzyme concentrations in otherwise asymptomaticsubjects with type 2 diabetes. Diabetes Metab Syndr Obes2012;5:419-24.
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 419-424
    • Malloy, J.1    Gurney, K.2    Shan, K.3    Yan, P.4    Chen, S.5
  • 9
    • 84886054507 scopus 로고    scopus 로고
    • Elevated serum lipaseactivity in adults with type 2 diabetes and no gastrointestinal symptoms
    • Steinberg W, Rosenstock J, De Vries JH, Thomsen AB. Elevated serum lipaseactivity in adults with Type 2 diabetes and no gastrointestinal symptoms.Gastroenterology 2012;142(Suppl 1):S93-4.
    • (2012) Gastroenterology , vol.142 , pp. S93-S94
    • Steinberg, W.1    Rosenstock, J.2    De Vries, J.H.3    Thomsen, A.B.4
  • 10
    • 84871169251 scopus 로고    scopus 로고
    • Longitudinal monitoring of lipase and amylase inadults with type 2 diabetes and obesity: Evidence from two phase 3 randomizedclinical trials with the once-daily glp-1 analogue liraglutide
    • Steinberg William, Hans De Vries J, Wadden Thomas A, Jensen Christine Bjern,Svendsen Claus Bo, et al. Longitudinal monitoring of lipase and amylase inadults with type 2 diabetes and obesity: evidence from two phase 3 randomizedclinical trials with the once-daily GLP-1 analogue liraglutide.Gastroenterology 2012;142(Suppl 1):S850-1.
    • (2012) Gastroenterology , vol.142 , pp. S850-S851
    • William, S.1    Hans De Vries, J.2    Wadden, T.A.3    Bjern, J.C.4    Bo, S.C.5
  • 11
    • 84894248931 scopus 로고    scopus 로고
    • Newlydiagnosed diabetes mellitus after acute pancreatitis" a systematic review andmeta-analysis
    • Das SL, Singh PP, Phillips AR, Murphy R, Windsor JA, Petrov MS. Newlydiagnosed diabetes mellitus after acute pancreatitis" a systematic review andmeta-analysis. Gut 2014;63:818-31.
    • (2014) Gut , vol.63 , pp. 818-831
    • Das, S.L.1    Singh, P.P.2    Phillips, A.R.3    Murphy, R.4    Windsor, J.A.5    Petrov, M.S.6
  • 13
    • 84884700278 scopus 로고    scopus 로고
    • Detection evaluation and treatment of diabetes mellitus in chronic pancreatitis:recommendations from PancreasFest 2012
    • Rickels MR, Bellin M, Toledo FG, Robertson RP, Andersen DK, Chari ST, et al.Detection, evaluation and treatment of diabetes mellitus in chronic pancreatitis:recommendations from PancreasFest 2012. Pancreatology 2013;13:336-42.
    • (2013) Pancreatology , vol.13 , pp. 336-342
    • Rickels, M.R.1    Bellin, M.2    Toledo, F.G.3    Robertson, R.P.4    Andersen, D.K.5    Chari, S.T.6
  • 16
    • 0242657573 scopus 로고    scopus 로고
    • High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. Amulticenter study screening fecal elastase 1 concentrations in 1021 diabeticpatients
    • Hardt PD, Hauenschild A, Nalop J, Marzeion AM, Jaeger C, Teichmann J, et al.High prevalence of exocrine pancreatic insufficiency in diabetes mellitus. Amulticenter study screening fecal elastase 1 concentrations in 1021 diabeticpatients. Pancreatology 2003;3:395-402.
    • (2003) Pancreatology , vol.3 , pp. 395-402
    • Hardt, P.D.1    Hauenschild, A.2    Nalop, J.3    Marzeion, A.M.4    Jaeger, C.5    Teichmann, J.6
  • 17
    • 41149108243 scopus 로고    scopus 로고
    • Low fecalelastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1diabetes mellitus
    • Hahn JU, Kerner W, Maisonneuve P, Lowenfels AB, Lankisch PG. Low fecalelastase 1 levels do not indicate exocrine pancreatic insufficiency in type-1diabetes mellitus. Pancreas 2008;36:274-8.
    • (2008) Pancreas , vol.36 , pp. 274-278
    • Hahn, J.U.1    Kerner, W.2    Maisonneuve, P.3    Lowenfels, A.B.4    Lankisch, P.G.5
  • 18
    • 64749112104 scopus 로고    scopus 로고
    • MRI and MRCPfindings of the pancreas in patients with diabetes mellitus: Compared withanalysis with pancreatic exocrine function determined by fecal elastase 1
    • Bilgin M, Balci NC, Momtahen AJ, Bilgin Y, Klor HU, Rau WS. MRI and MRCPfindings of the pancreas in patients with diabetes mellitus: compared withanalysis with pancreatic exocrine function determined by fecal elastase 1.J Clin Gastroenterol 2009;43:165-70.
    • (2009) J Clin Gastroenterol , vol.43 , pp. 165-170
    • Bilgin, M.1    Balci, N.C.2    Momtahen, A.J.3    Bilgin, Y.4    Klor, H.U.5    Rau, W.S.6
  • 19
    • 84904383464 scopus 로고    scopus 로고
    • 13C-mixed triglyceride breath testfor evaluation of pancreatic exocrine function in diabetes mellitus
    • Keller J, Layer P, Bruckel S, Jahr C, Rosien U. 13C-mixed triglyceride breath testfor evaluation of pancreatic exocrine function in diabetes mellitus. Pancreas2014;43:842-8.
    • (2014) Pancreas , vol.43 , pp. 842-848
    • Keller, J.1    Layer, P.2    Bruckel, S.3    Jahr, C.4    Rosien, U.5
  • 20
    • 80053529657 scopus 로고    scopus 로고
    • Exocrine pancreatic insufficiency in diabetes mellitus: Acomplication of diabetic neuropathy or a different type of diabetes?
    • [epub]
    • Hardt PD, Ewald N. Exocrine pancreatic insufficiency in diabetes mellitus: acomplication of diabetic neuropathy or a different type of diabetes? ExpDiabetes Res 2011:761950 [epub].
    • (2011) Exp Diabetes Res , pp. 761950
    • Hardt, P.D.1    Ewald, N.2
  • 22
    • 79959839165 scopus 로고    scopus 로고
    • Weightloss precedes cancer-specific symptoms in pancreatic cancer-associated diabetesmellitus
    • Hart PA, Kamada P, Rabe KG, Srinivasan S, Basu A, Aggarwal G, et al. Weightloss precedes cancer-specific symptoms in pancreatic cancer-associated diabetesmellitus. Pancreas 2011;40:768-72.
    • (2011) Pancreas , vol.40 , pp. 768-772
    • Hart, P.A.1    Kamada, P.2    Rabe, K.G.3    Srinivasan, S.4    Basu, A.5    Aggarwal, G.6
  • 24
    • 84908028466 scopus 로고    scopus 로고
    • Metformin is associated withreduced risk of pancreatic cancer in patients with Type 2 diabetes mellitus: Asystematic review and meta-analysis
    • Wang Z, Lai ST, Xie L, Zhao JD, Ma NY, Zhu J, et al. Metformin is associated withreduced risk of pancreatic cancer in patients with Type 2 diabetes mellitus: asystematic review and meta-analysis. Diabetes Res Clin Pract 2014;106:19-26.
    • (2014) Diabetes Res Clin Pract , vol.106 , pp. 19-26
    • Wang, Z.1    Lai, S.T.2    Xie, L.3    Zhao, J.D.4    Ma, N.Y.5    Zhu, J.6
  • 25
    • 84875964059 scopus 로고    scopus 로고
    • Anti-diabeticmedications and risk of pancreatic cancer in patients with diabetesmellitus: A systematic review and meta-analysis
    • Singh S, Singh PP, Singh AG, Murad MH, McWilliams RR, Chari ST. Anti-diabeticmedications and risk of pancreatic cancer in patients with diabetesmellitus: a systematic review and meta-analysis. Am J Gastroenterol2013;108:510-9.
    • (2013) Am J Gastroenterol , vol.108 , pp. 510-519
    • Singh, S.1    Singh, P.P.2    Singh, A.G.3    Murad, M.H.4    McWilliams, R.R.5    Chari, S.T.6
  • 27
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis,pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. Pancreatitis,pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies.Gastroenterology 2011;141:150-6.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 28
    • 84884903039 scopus 로고    scopus 로고
    • The association ofpancreatitis with antidiabetic drug use: Gaining insight through the FDApharmacovigilance database
    • Raschi E, Piccinni C, Poluzzi E, Marchesini G, De Ponti F. The association ofpancreatitis with antidiabetic drug use: gaining insight through the FDApharmacovigilance database. Acta Diabetol 2013;50:569-77.
    • (2013) Acta Diabetol , vol.50 , pp. 569-577
    • Raschi, E.1    Piccinni, C.2    Poluzzi, E.3    Marchesini, G.4    De Ponti, F.5
  • 30
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safetysurveillance system to assess the risk of acute pancreatitis with exanetide orsitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K. Use of a claims-based active drug safetysurveillance system to assess the risk of acute pancreatitis with exanetide orsitagliptin compared to metformin or glyburide. Curr Med Res Opin 2009;25:1019-27.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold Chan, K.3
  • 31
    • 79951704452 scopus 로고    scopus 로고
    • Acute pancreatitis in Type 2 diabetes treatedwith exenatide or sitagliptin: A retrospective observational pharmacy claimsanalysis
    • Garg R, Chen W, Pendergrass M. Acute pancreatitis in Type 2 diabetes treatedwith exenatide or sitagliptin: a retrospective observational pharmacy claimsanalysis. Diabetes Care 2010;33:2349-54.
    • (2010) Diabetes Care , vol.33 , pp. 2349-2354
    • Garg, R.1    Chen, W.2    Pendergrass, M.3
  • 32
    • 84885384645 scopus 로고    scopus 로고
    • Safety and tolerabilityof sitagliptin in type 2 diabetes: Pooled analysis of 25 clinical studies
    • Engel SS, Round E, Golm GT, Kaufman KD, Goldstein BJ. Safety and tolerabilityof sitagliptin in type 2 diabetes: pooled analysis of 25 clinical studies. DiabetesTher 2013;4:119-45.
    • (2013) DiabetesTher , vol.4 , pp. 119-145
    • Engel, S.S.1    Round, E.2    Golm, G.T.3    Kaufman, K.D.4    Goldstein, B.J.5
  • 33
    • 84903519951 scopus 로고    scopus 로고
    • Risk of pancreatitis in patients treated with incretinbasedtherapies
    • Meier JJ, Nauck MA. Risk of pancreatitis in patients treated with incretinbasedtherapies. Diabetologia 2014;57:1320-4.
    • (2014) Diabetologia , vol.57 , pp. 1320-1324
    • Meier, J.J.1    Nauck, M.A.2
  • 34
    • 84876063836 scopus 로고    scopus 로고
    • Glucagonlikepeptide 1-based therapies and risk of hospitalization for acute pancreatitis intype 2 diabetes mellitus: A population-based matched case-control study
    • Singh S, Chang HY, Richards TM, Weiner JP, Clark JM, Segal JB. Glucagonlikepeptide 1-based therapies and risk of hospitalization for acute pancreatitis intype 2 diabetes mellitus: a population-based matched case-control study.JAMA 2013;173:534-9.
    • (2013) JAMA , vol.173 , pp. 534-539
    • Singh, S.1    Chang, H.Y.2    Richards, T.M.3    Weiner, J.P.4    Clark, J.M.5    Segal, J.B.6
  • 38
    • 84899547978 scopus 로고    scopus 로고
    • Incretin baseddrugs and risk of acute pancreatitis: Cohort study
    • Apr 24
    • Faillie JL, Azoulay L, Patenaude V, Hillaire-Buys D, Suissa S. Incretin baseddrugs and risk of acute pancreatitis: cohort study. BMJ 2014 Apr 24;348:g2780.
    • (2014) BMJ , vol.348 , pp. g2780
    • Faillie, J.L.1    Azoulay, L.2    Patenaude, V.3    Hillaire-Buys, D.4    Suissa, S.5
  • 39
    • 84899029163 scopus 로고    scopus 로고
    • Incretintreatment and risk of pancreatitis in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of randomised and non-randomisedstudies
    • Li L, Shen J, Bala MM, Busse JW, Ebrahim S, Vandvik PO, et al. Incretintreatment and risk of pancreatitis in patients with type 2 diabetes mellitus:a systematic review and meta-analysis of randomised and non-randomisedstudies. BMJ 2014;348:g2366.
    • (2014) BMJ , vol.348 , pp. g2366
    • Li, L.1    Shen, J.2    Bala, M.M.3    Busse, J.W.4    Ebrahim, S.5    Vandvik, P.O.6
  • 40
    • 84905403704 scopus 로고    scopus 로고
    • Incidence of pancreatitis and pancreatic cancer in a randomized controlledtrial (SAVOR-TIMI 53) of the dipeptidyl peptidase-4 inhibitor saxagliptin
    • Raz I, Bhatt DL, Hirshberg B, Mosenzon O, Scirica BM, Umez-Eronini A, et al.Incidence of pancreatitis and pancreatic cancer in a randomized controlledtrial (SAVOR-TIMI 53) of the dipeptidyl peptidase-4 inhibitor saxagliptin.Diabetes Care 2014;37:2435-41.
    • (2014) Diabetes Care , vol.37 , pp. 2435-2441
    • Raz, I.1    Bhatt, D.L.2    Hirshberg, B.3    Mosenzon, O.4    Scirica, B.M.5    Umez-Eronini, A.6
  • 41
    • 84878352363 scopus 로고    scopus 로고
    • Marked expansion of exocrine and endocrine pancreas withincretin therapy in humans with increased exocrine pancreas dysplasia andthe potential for glucagon-producing neuroendocrine tumors
    • Butler AE, Campbell-Thompson M, Gurlo T, Dawson DW, Atkinson M,Butler PC. Marked expansion of exocrine and endocrine pancreas withincretin therapy in humans with increased exocrine pancreas dysplasia andthe potential for glucagon-producing neuroendocrine tumors. Diabetes2013;62:2595-604.
    • (2013) Diabetes , vol.62 , pp. 2595-2604
    • Butler, A.E.1    Campbell-Thompson, M.2    Gurlo, T.3    Dawson, D.W.4    Atkinson, M.5    Butler, P.C.6
  • 42
    • 84879238656 scopus 로고    scopus 로고
    • Incretics and the risk of neoplasis
    • Halfdanarson TR, Pannala R. Incretics and the risk of neoplasis. BMJ 2013;346:f3750.
    • (2013) BMJ , vol.346 , pp. f3750
    • Halfdanarson, T.R.1    Pannala, R.2


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