Transmembrane-6 superfamily member 2 (TM6SF2) E167K variant increases susceptibility to hepatic steatosis in obese children

Digestive and Liver Disease

Volumn 48, Issue 1, 2016, Pages 100-101

  Mancina, Rosellina M ^a   Sentinelli, Federica ^b   Incani, Michela ^c   Bertoccini, Laura ^b   Russo, Cristina ^d   Romeo, Stefano ^a,d   Baroni, Marco G ^b  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF CAGLIARI   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; TRIACYLGLYCEROL; MEMBRANE PROTEIN; TM6SF2 PROTEIN, HUMAN;

AGE; BODY MASS; CHILD; CHILDHOOD OBESITY; CHOLESTEROL BLOOD LEVEL; DEVELOPMENTAL STAGE; ECHOGRAPHY; FAT CONTENT; GENDER; GENE; GENE FREQUENCY; GENE FUNCTION; GENETIC ASSOCIATION; GENETIC BACKGROUND; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; ITALY; LETTER; LIPID STORAGE; METABOLIC DISORDER; NONALCOHOLIC FATTY LIVER; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; TM6SF2 GENE; TRIACYLGLYCEROL BLOOD LEVEL; DIAGNOSTIC IMAGING; FATTY LIVER; FEMALE; GENETIC PREDISPOSITION; GENETICS; MALE; OBESITY;

FATTY LIVER; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; ITALY; MALE; MEMBRANE PROTEINS; OBESITY; PREVALENCE; ULTRASONOGRAPHY;

EID: 84955675483     PISSN: 15908658     EISSN: 18783562     Source Type: Journal    
DOI: 10.1016/j.dld.2015.10.003     Document Type: Letter

References (5)

1. http://www.epicentro.iss.it/okkioallasalute/pdf2015/SINTESI_16gen.pdf.
2. Dongiovanni P., Petta S., Maglio C., et al. TM6SF2 gene variant disentangles nonalcoholic steatohepatitis from cardiovascular disease. Hepatology 2014.
3. Grandone A., Cozzolino D., Marzuillo P., et al. TM6SF2 Glu167Lys polymorphism is associated with low levels of LDL-cholesterol and increased liver injury in obese children. Pediatric Obesity 2015, [April 20].
4. Romeo S., Sentinelli F., Cambuli V.M., et al. The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life. Journal of Hepatology 2010, 53:335-338.
5. Zhou Y., Llauradó G., Orešič M., et al. Circulating triacylglycerol signatures and insulin sensitivity in NAFLD associated with the E167K variant in TM6SF2. Journal of Hepatology 2015, 62:657-663.