Short-Term Effects of Kefir-Fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in a Randomized Clinical Trial of Osteoporotic Patients

PLoS ONE

Volumn 10, Issue 12, 2015, Pages

  Tu, Min Yu ^a,b,c,d   Chen, Hsiao Ling ^e   Tung, Yu Tang ^a   Kao, Chao Chih ^a   Hu, Fu Chang ^f   Chen, Chuan Mu ^a  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^c HUNGKUANG UNIVERSITY   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^e DA YEH UNIVERSITY   (Taiwan)

^f NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; OSTEOCALCIN; PARATHYROID HORMONE; CALCIUM; CALCIUM CARBONATE; COLLAGEN TYPE 1; COLLAGEN TYPE I TRIMERIC CROSS-LINKED PEPTIDE; PEPTIDE;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; BONE DENSITY; BONE METABOLISM; BONE TURNOVER; CONTROLLED STUDY; DIET SUPPLEMENTATION; DOUBLE BLIND PROCEDURE; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FERMENTED MILK; FOOD INTAKE; HUMAN; MAJOR CLINICAL STUDY; MALE; MILK; OSSIFICATION; OSTEOLYSIS; OSTEOPOROSIS; PARATHYROID HORMONE BLOOD LEVEL; PILOT STUDY; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; THERAPY EFFECT; TREATMENT DURATION; BLOOD; BONE; CLINICAL TRIAL; DIET THERAPY; DIETARY SUPPLEMENT; FERMENTED MILK PRODUCT; METABOLISM; MIDDLE AGED; PATHOLOGY; PHOTON ABSORPTIOMETRY; PLACEBO EFFECT; TREATMENT OUTCOME;

ABSORPTIOMETRY, PHOTON; AGED; BONE AND BONES; BONE DENSITY; CALCIUM; CALCIUM CARBONATE; COLLAGEN TYPE I; CULTURED MILK PRODUCTS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OSTEOCALCIN; OSTEOPOROSIS; PARATHYROID HORMONE; PEPTIDES; PLACEBO EFFECT; TREATMENT OUTCOME;

EID: 84955620092     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0144231     Document Type: Article

References (45)

1. Ager JW III, Balooch G, Ritchie RO. Fracture, aging, and disease in bone. J Mater Res 2006; 21: 1878-1892.
2. Rubin MA, Jasiuk I, Taylor J, Rubin J, Ganey T, Apkarian RP. TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone 2003; 33: 270-282. PMID: 13678767
3. Manolagas SC, Jilka RL. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 1995; 332: 305-311. PMID: 7816067
4. Laurent Benhamou C. Bone ultrastructure: evolution during osteoporosis and aging. Osteoporos Int 2009; 20: 1085-1087. doi: 10.1007/s00198-009-0867-4 PMID: 19340498
5. Zioupos P, Currey JD. Changes in the stiffness, strength, and toughness of human cortical bone with age. Bone 1998; 22: 57-66. PMID: 9437514
6. Johnell O, Kanis JA. An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 2006; 17: 1726-1733. PMID: 16983459
7. Sambrook P, Cooper C. Osteoporosis. Lancet 2006; 367: 2010-2018. PMID: 16782492
8. Dawson-Hughes B, Dallal GE, Krall EA, Sadowski L, Sahyoun N, Tannenbaum S. A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. N Engl J Med 1990; 323: 878-883. PMID: 2203964
9. Suleiman S, Nelson M, Li FM, Buxton-Thomas M, Moniz C. Effect of calcium intake and physical activity level on bone mass and turnover in healthy, white, postmenopausal women. Am J Clin Nutr 1997; 66: 937-943. PMID: 9322571
10. McKane WR, Khosla S, Egan KS, Robins SP, Burritt MF, Riggs BL. Role of calcium intake in modulating age-related increases in parathyroid function and bone resorption. J Clin Endocrinol Metab 1996; 81: 1699-1703. PMID: 8626819
11. Ammann P. Bone strength and ultrastructure. Osteoporos Int 1996; 20: 1081-1083.
12. Takada Y, Aoe S, Kumegawa M. Whey protein stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells. Biochem Bioph Res Commun 1996; 223: 445-449.
13. Takada Y, Kobayashi N, Matsuyama H, Kato K, Yamamura J, Yahiro M, et al. Whey protein suppresses the osteoclast-mediated bone resorption and osteoclast cell formation. Int Dairy J 1997; 7: 821-825.
14. Ammann P, Bonjour JP, Rizzoli R. Essential amino acid supplements increase muscle weight, bone mass and bone strength in adult osteoporotic rats. J Musculoskelet Neuronal Interact 2000; 1: 43-44. PMID: 15758524
15. Heaney RP. Calcium, dairy products and osteoporosis. J Am Coll Nutr 2000; 19: S83-S99.
16. Cashman KD. Milk minerals (including trace elements) and bone health. Int Dairy J 2006; 16: 1389-1398.
17. Bouhallab S, Bouglé D. Biopeptides of milk: Caseinophosphopeptides and mineral bioavailability. Reprod Nutr Dev 2004; 44: 493-498. PMID: 15636166
18. Scholz-Ahrens KE, Schrezenmeir J. Effects of bioactive substances in milk on mineral and trace element metabolism with special reference to casein phosphopeptides. Br J Nutr 2000; 84: S147-S153. PMID: 11242459
19. Sato R, Noguchi T, Naito H. Casein phosphopeptide (CPP) enhances calcium absorption from the ligated segment of rat small intestine. J Nutr Sci Vitaminol (Tokyo) 1986; 32: 67-76.
20. Meisel H, Bockelmann W. Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho- functional properties. Antonie Van Leeuwenhoek 1999; 76: 207-215. PMID: 10532380
21. Erba D, Ciappellano S, Testolin G. Effect of the ratio of casein phosphopeptides to calcium (w/w) on passive calcium transport in the distal small intestine of rats. Nutrition 2002; 18: 743-746. PMID: 12297210
22. Bennett T, Desmond A, Harrington M, McDonagh D, FitzGerald R, Flynn A, et al. The effect of high intakes of casein and casein phosphopeptide on calcium absorption in the rat. Br J Nutr 2000; 83: 673-680. PMID: 10911776
23. Narva M, Nevala R, Poussa T, Korpela R. The effect of Lactobacillus helveticus fermented milk on acute changes in calcium metabolism in postmenopausal women. Eur J Nutr 2004; 43: 61-68. PMID: 15083312
24. Adolphi B, Scholz-Ahrens KE, de Vrese M, Acil Y, Laue C, Schrezenmeir J. Short-term effect of bedtime consumption of fermented milk supplemented with calcium, inulin-type fructans and caseinphosphopeptides on bone metabolism in healthy, postmenopausal women. Eur J Nutr 2009; 48: 45-53. doi: 10.1007/s00394-008-0759-y PMID: 19030908
25. Chen HL, Tung YT, Tsai CL, Lai CW, Tsai HC, Lin YL, et al. Kefir improves fatty liver syndrome through inhibited lipogenesis pathway in leptin-deficient ob/ob knockout mice. Int J Obesity 2014; 38: 1172-1179.
26. Chen HL, Tung YT, Chuang CH, Tu MY, Tsai TC, Chang SY, et al. Kefir improves bone mass and microarchitecture in an ovariectomized rat model of postmenopausal osteoporosis. Osteoporosis Int 2015; 26: 589-599.
27. Chang YT, Chen CM, Tu MY, Chen HL, Chang SY, Tsai TC, et al. Effects of osteoporosis and nutrition supplements on structures and nanomechanical properties of bone tissue. J Mechan Behav Biomed Materi 2011; 4: 1412-1420.
28. Tung YT, Tang TY, Chen HL, Yang SH, Chong KY, Chen CM. Lactoferrin protects against chemicalinduced rat liver fibrosis through inhibiting stellate cells activation. J Dairy Sci 2014; 97: 3281-3291. doi: 10.3168/jds.2013-7505 PMID: 24731632
29. Black RE, Williams SM, Jones IE, Goulding A. Children who avoid drinking cow milk have low dietary calcium intakes and poor bone health. Am J Clin Nutr 2002; 76: 675-680. PMID: 12198017
30. Hu JF, Zhao XH, Jia JB, Parpia B, Campbell TC. Dietary calcium and bone density among middle-aged and elderly women in China. Am J Clin Nutr 1993; 58: 219-227. PMID: 8338050
31. Murphy S, Khaw KT, May H, Compston JE. Milk consumption and bone mineral density in middle aged and elderly women. Br Med J 1994; 308: 939-941.
32. Recker RR, Heaney RP. The effect of milk supplements on calcium metabolism, bone metabolism and calcium balance. Am J Clin Nutr 1985; 41: 254-263. PMID: 3838218
33. Matkovic V, Landoll JD, Badenhop-Stevens NE, Ha EY, Crncevic-Orlic Z, Li B, et al. Nutrition influences skeletal development from childhood to adulthood: a study of hip, spine, and forearm in adolescent females. J Nutr 2004; 134: S701-S705.
34. Uenishi K, Ishida H, Toba Y, Aoe S, Itabashi A, Takada Y. Milk basic protein increases bone mineral density and improves bone metabolism in healthy young women. Osteoporos Int 2007; 18: 385-390. PMID: 17048062
35. Möller NP, Scholz-Ahrens KE, Roos N, Schrezenmeir J. Bioactive peptides and proteins from foods: indication for health effects. Eur J Nutr 2008; 47: 171-182. doi: 10.1007/s00394-008-0710-2 PMID: 18506385
36. Blumsohn A, Herrington K, Hannon RA, Shao P, Eyre DR, Eastell R. The effect of calcium supplementation on the circadian-rhythm of bone resorption. J Clin Endocrinol Metabol 1994; 79: 730-735.
37. Horowitz M, Need AG, Morris HA, Wishart J, Nordin BE. Biochemical effects of calcium supplementation in postmenopausal osteoporosis. Eur J Clin Nutr 1988; 42: 775-778. PMID: 3181110
38. Martini L, Wood RJ. Relative bioavailability of calcium-rich dietary sources in the elderly. Am J Clin Nutr 2002; 76: 1345-1350. PMID: 12450902
39. Matkovic V, Heaney RP. Calcium balance during human growth: evidence for threshold behavior. Am J Clin Nutr 1992; 55: 992-996. PMID: 1570810
40. Reeves RE, Latour NG. Calcium phosphate sequestering phosphopeptide from casein. Science 1958; 128: 472. PMID: 13568811
41. Naito H, Suzuki H. Further evidence for the formation in vivo of phosphopeptide in the intestinal lumen from dietary beta-casein. Agric Biol Chem 1974; 38: 1543-1545.
42. Riggs BL, O'Fallon WM, Muhs J, O'Connor MK, Kumar R, Melton LJ III. Long-term effects of calcium supplementation on serum parathyroid hormone level, bone turnover, and bone loss in elderly women. J Bone Miner Res 1998; 13: 168-174. PMID: 9495509
43. Scholz-Ahrens KE, Barth CA, Drescher K, Goralczyk R, Rambeck WA, Wehr U, et al. Modulation of bone markers by dietary calcium in ovariectomized minipigs. Osteoporos Int 1996; 6: S242.
44. Scholz-Ahrens KE, de Vrese M, Barth CA. Influence of casein-derived phosphopeptides on the bioavailability of calcium in vitamin D-deficient miniature pigs. In: Norman AW, Bouillon R, Thomasset M. Vitamin D, gene regulation, structure-function analysis and clinical application. Berlin: Walter de Gruyter. 1991; pp. 724-725.
45. Kurland ES, Cosman F, McMahon DJ, Rosen CJ, Lindsay R, Bilezikian JP. Parathyroid hormone as a therapy for idiopathic osteoporosis in men: effects on bone mineral density and bone markers. J Clin Endocrinol Metab 2000; 85: 3069-3076. PMID: 10999788