iPSC-derived human cardiac progenitor cells improve ventricular remodelling via angiogenesis and interstitial networking of infarcted myocardium

Journal of Cellular and Molecular Medicine

Volumn 20, Issue 2, 2016, Pages 323-332

  Ja, K P Myu Mia ^a   Miao, Qingfeng ^a,b   Zhen Tee, Nicole Gui ^a   Lim, Sze Yun ^a   Nandihalli, Manasi ^a   J A Ramachandra, Chrishan ^a   Mehta, Ashish ^a,c   Shim, Winston ^a,c  

^a DEPARTMENT OF CARDIOLOGY   (Singapore)

^b HEBEI MEDICAL UNIVERSITY   (China)

^c DUKE NUS MEDICAL SCHOOL   (Singapore)

Author keywords

Cardiac progenitors; Cardiac repair; Cardiomyocytes; Interstitial cells; Telocytes

Indexed keywords

INTEGRIN; LAMININ;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIAC STEM CELL; CELL TRANSPLANTATION; CONTROLLED STUDY; ECHOCARDIOGRAPHY; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HEART FUNCTION; HEART INFARCTION; HEART INFARCTION SIZE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE CELL; HEART STROKE VOLUME; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MOUSE; NEOVASCULARIZATION (PATHOLOGY); NEWBORN; NONHUMAN; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; TELOCYTE; ANIMAL; CARDIAC MUSCLE; CARDIAC MUSCLE CELL; CELL LINE; HEART VENTRICLE REMODELING; INDUCED PLURIPOTENT STEM CELL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SCID MOUSE; STEM CELL;

ANIMALS; CELL LINE; FEMALE; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, SCID; MYOCARDIAL INFARCTION; MYOCARDIUM; MYOCYTES, CARDIAC; NEOVASCULARIZATION, PHYSIOLOGIC; STEM CELLS; VENTRICULAR REMODELING;

EID: 84955593081     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12725     Document Type: Article

References (44)

1. Mehta A, Shim W. Cardiac stem cell therapy: stemness or commitment? Cell Transplant. 2013; 22: 1-14.
2. Shim W, Mehta A, Wong P, et al. Critical path in cardiac stem cell therapy: an update on cell delivery. Cytotherapy. 2013; 15: 399-415.
3. Menasche P, Vanneaux V, Hagege A, et al. Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report. Eur Heart J. 2015; 36: 2011-7.
4. Chong JJ, Yang X, Don CW, et al. Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts. Nature. 2014; 510: 273-7.
5. Menasche P. Stem cell therapy for chronic heart failure: lessons from a 15-year experience. C R Biol. 2011; 334: 489-96.
6. Bolli R, Chugh AR, D'Amario D, et al. Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet. 2011; 378: 1847-57.
7. Makkar RR, Smith RR, Cheng K, et al. Intracoronary cardiosphere-derived cells for heart regeneration after myocardial infarction (CADUCEUS): a prospective, randomised phase 1 trial. Lancet. 2012; 379: 895-904.
8. Mehta A, Chung YY, Ng A, et al. Pharmacological response of human cardiomyocytes derived from virus-free induced pluripotent stem cells. Cardiovasc Res. 2011; 91: 577-86.
9. Mehta A, Ramachandra CJ, Sequiera GL, et al. Phasic modulation of Wnt signaling enhances cardiac differentiation in human pluripotent stem cells by recapitulating developmental ontogeny. Biochim Biophys Acta. 2014; 1843: 2394-402.
10. Miao Q, Shim W, Tee N, et al. iPSC-derived human mesenchymal stem cells improve myocardial strain of infarcted myocardium. J Cell Mol Med. 2014; 18: 1644-54.
11. Quinones MA, Waggoner AD, Reduto LA, et al. A new, simplified and accurate method for determining ejection fraction with two-dimensional echocardiography. Circulation. 1981; 64: 744-53.
12. Pacher P, Mabley JG, Liaudet L, et al. Left ventricular pressure-volume relationship in a rat model of advanced aging-associated heart failure. Am J Physiol Heart Circ Physiol. 2004; 287: H2132-7.
13. Suciu L, Popescu LM, Regalia T, et al. Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med. 2009; 13: 771-7.
14. Popescu LM, Manole CG, Gherghiceanu M, et al. Telocytes in human epicardium. J Cell Mol Med. 2010; 14: 2085-93.
15. Sheng J, Shim W, Lu J, et al. Electrophysiology of human cardiac atrial and ventricular telocytes. J Cell Mol Med. 2014; 18: 355-62.
16. Tang XL, Rokosh G, Sanganalmath SK, et al. Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation. 2010; 121: 293-305.
17. Li TS, Cheng K, Malliaras K, et al. Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol. 2012; 59: 942-53.
18. Dubois NC, Craft AM, Sharma P, et al. SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. Nat Biotechnol. 2011; 29: 1011-8.
19. Elliott DA, Braam SR, Koutsis K, et al. NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes. Nat Methods. 2011; 8: 1037-40.
20. Tuckwell DS, Weston SA, Humphries MJ. Integrins: a review of their structure and mechanisms of ligand binding. Symp Soc Exp Biol. 1993; 47: 107-36.
21. Belkin AM, Stepp MA. Integrins as receptors for laminins. Microsc Res Tech. 2000; 51: 280-301.
22. Nishiuchi R, Takagi J, Hayashi M, et al. Ligand-binding specificities of laminin-binding integrins: a comprehensive survey of laminin-integrin interactions using recombinant alpha3beta1, alpha6beta1, alpha7beta1 and alpha6beta4 integrins. Matrix Biol. 2006; 25: 189-97.
23. Tryggvason K. Biological relevant laminins. Genet Eng Biotechnol News. 2013; 33: 36-7.
24. Simon-Assmann P, Orend G, Mammadova-Bach E, et al. Role of laminins in physiological and pathological angiogenesis. Int J Dev Biol. 2011; 55: 455-65.
25. Collins LR, Priest C, Caras I, et al. Proceedings: moving toward cell-based therapies for heart disease. Stem Cells Transl Med. 2015; 4: 863-7.
26. Fisher SA, Doree C, Mathur A, et al. Meta-analysis of cell therapy trials for patients with heart failure. Circ Res. 2015; 116: 1361-77.
27. Afzal MR, Samanta A, Shah ZI, et al. Adult bone marrow cell therapy for ischemic heart disease: evidence and insights from randomized controlled trials. Circ Res. 2015; 117: 558-75.
28. Fernandes S, Naumova AV, Zhu WZ, et al. Human embryonic stem cell-derived cardiomyocytes engraft but do not alter cardiac remodeling after chronic infarction in rats. J Mol Cell Cardiol. 2010; 49: 941-9.
29. den Haan MC, Grauss RW, Smits AM, et al. Cardiomyogenic differentiation-independent improvement of cardiac function by human cardiomyocyte progenitor cell injection in ischaemic mouse hearts. J Cell Mol Med. 2012; 16: 1508-21.
30. Chugh AR, Beache GM, Loughran JH, et al. Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation. 2012; 126: S54-64.
31. Zhao B, Chen S, Liu J, et al. Cardiac telocytes were decreased during myocardial infarction and their therapeutic effects for ischaemic heart in rat. J Cell Mol Med. 2013; 17: 123-33.
32. van Laake LW, van Donselaar EG, Monshouwer-Kloots J, et al. Extracellular matrix formation after transplantation of human embryonic stem cell-derived cardiomyocytes. Cell Mol Life Sci. 2010; 67: 277-90.
33. Zhao B, Liao Z, Chen S, et al. Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats. J Cell Mol Med. 2014; 18: 780-9.
34. Albulescu R, Tanase C, Codrici E, et al. The secretome of myocardial telocytes modulates the activity of cardiac stem cells. J Cell Mol Med. 2015; 19: 1783-94.
35. Fertig ET, Gherghiceanu M, Popescu LM. Extracellular vesicles release by cardiac telocytes: electron microscopy and electron tomography. J Cell Mol Med. 2014; 18: 1938-43.
36. Manole CG, Cismasiu V, Gherghiceanu M, et al. Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis. J Cell Mol Med. 2011; 15: 2284-96.
37. Zheng Y, Cretoiu D, Yan G, et al. Comparative proteomic analysis of human lung telocytes with fibroblasts. J Cell Mol Med. 2014; 18: 568-89.
38. Cretoiu D, Hummel E, Zimmermann H, et al. Human cardiac telocytes: 3D imaging by FIB-SEM tomography. J Cell Mol Med. 2014; 18: 2157-64.
39. Mayer U, Saher G, Fassler R, et al. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Nat Genet. 1997; 17: 318-23.
40. Laflamme MA, Chen KY, Naumova AV, et al. Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts. Nat Biotechnol. 2007; 25: 1015-24.
41. Anderson ME, Goldhaber J, Houser SR, et al. Embryonic stem cell-derived cardiac myocytes are not ready for human trials. Circ Res. 2014; 115: 335-8.
42. Malliaras K, Zhang Y, Seinfeld J, et al. Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heart. EMBO Mol Med. 2013; 5: 191-209.
43. Qian L, Shim W, Gu Y, et al. Hemodynamic contribution of stem cell scaffolding in acute injured myocardium. Tissue Eng Part A. 2012; 18: 1652-63.
44. Bani D, Formigli L, Gherghiceanu M, et al. Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med. 2010; 14: 2531-8.