Familial lecithin:cholesterol acyltransferase deficiency: First-in-human treatment with enzyme replacement

Journal of Clinical Lipidology

Volumn 10, Issue 2, 2016, Pages 356-367

  Shamburek, Robert D ^a   Bakker Arkema, Rebecca ^b,c   Auerbach, Bruce J ^b   Krause, Brian R ^b   Homan, Reynold ^b   Amar, Marcelo J ^a   Freeman, Lita A ^a   Remaley, Alan T ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b AlphaCore Pharma   (United States)

^c MEDIMMUNE   (United States)

Author keywords

Cholesterol; HDL; LCAT; Lecithin cholesterol acyltransferase; Lecithin cholesterol acyltransferase deficiency; Lipoprotein X; Recombinant enzyme replacement; Renal disease; Triglyceride

Indexed keywords

ACP 501; HIGH DENSITY LIPOPROTEIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; PHOSPHATIDYLCHOLINE STEROL ACYLTRANSFERASE; PRE BETA HIGH DENSITY LIPOPROTEIN; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; RECOMBINANT PROTEIN;

ADULT; ANEMIA; ARTICLE; CASE REPORT; DISEASE COURSE; DRUG DOSE ESCALATION; DRUG SAFETY; ENZYME REPLACEMENT; FAST PROTEIN LIQUID CHROMATOGRAPHY; HUMAN; KIDNEY DISEASE; KIDNEY FUNCTION; LECITHIN CHOLESTEROL ACYLTRANSFERASE DEFICIENCY; LIPID BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; MALE; MEAL; MIDDLE AGED; POSTPRANDIAL STATE; PRIORITY JOURNAL; BLOOD; BLOOD EXAMINATION; COMPLICATION; DRUG EFFECTS; ENZYMOLOGY; KIDNEY; SAFETY;

ANEMIA; CHOLESTEROL, HDL; DISEASE PROGRESSION; HEMATOLOGIC TESTS; HUMANS; KIDNEY; LECITHIN CHOLESTEROL ACYLTRANSFERASE DEFICIENCY; MALE; MIDDLE AGED; PHOSPHATIDYLCHOLINE-STEROL O-ACYLTRANSFERASE; RECOMBINANT PROTEINS; SAFETY;

EID: 84955585855     PISSN: 19332874     EISSN: 18764789     Source Type: Journal    
DOI: 10.1016/j.jacl.2015.12.007     Document Type: Article

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