The emerging role of complex modifications of tRNALys UUU in signaling pathways

Microbial Cell

Volumn 2, Issue 1, 2015, Pages 1-4

  Thiaville, Patrick C ^a,b   de Crécy Lagard, Valérie ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

GCN4; Thiolation; TOR; tRNA; UPR

Indexed keywords

EID: 84955501573     PISSN: None     EISSN: 23112638     Source Type: Journal    
DOI: 10.15698/mic2015.01.185     Document Type: Article

References (25)

1. Dalebroux ZD, Swanson MS (2012). ppGpp: magic beyond RNA polymerase. Nat Rev Microbiol 10(3): 203-212.
2. Green NJ, Grundy FJ, Henkin TM (2010). The T box mechanism: tRNA as a regulatory molecule. FEBS Lett 584(2): 318-324.
3. Hinnebusch AG (2005). Translational regulation of GCN4 and the general amino acid control of yeast. Annu Rev Microbiol 59: 407-450.
4. Scheidt V, Judes A, Bar C, Klassen R, Schaffrath R (2014). Loss of wobble uridine modification in tRNA anticodons interferes with TOR pathway signaling. Microbial Cell 1 (12): 416-424.
5. El Yacoubi B, Bailly M, de Crécy-Lagard V (2012). Biosynthesis and function of posttranscriptional modifications of transfer RNAs. Annu Rev Genet 46: 69-95.
6. 6A tRNA modification in Archaea and Eukarya. Nucleic Acids Res 41(3): 1953-1964.
7. Meng F-L, Hu Y, Shen N, Tong X-J, Wang J, Ding J, Zhou J-Q (2009). Sua5p a single-stranded telomeric DNA-binding protein facilitates telomere replication. Embo J 28(10): 1466.
8. Chen C, Huang B, Eliasson M, Rydén P, Byström AS (2011). Elongator complex influences telomeric gene silencing and DNA damage response by its role in wobble uridine tRNA modification. PLoS Genet 7(9): e1002258.
9. Esberg A, Huang B, Johansson MJO, Byström AS (2006). Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Molecular Cell 24(1): 139.
10. Fernandez-Vazquez J, Vargas-Perez I, Sanso M, Buhne K, Carmona M, Paulo E, Hermand D, Rodriguez-Gabriel M, Ayte J, Leidel S, Hidalgo E (2013). Modification of tRNA(Lys) UUU by elongator is essential for efficient translation of stress mRNAs. PLoS Genet 9(7): e1003647.
11. Bauer F, Matsuyama A, Candiracci J, Dieu M, Scheliga J, Wolf DA, Yoshida M, Hermand D (2012). Translational control of cell division by Elongator. Cell Rep 1(5): 424-433.
12. Rezgui VAN, Tyagi K, Ranjan N, Konevega AL, Mittelstaet J, Rodnina MV, Peter M, Pedrioli PGA (2013). tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding. Proc Natl Acad Sci U S A 110(30): 12289-12294.
13. Laxman S, Sutter BM, Wu X, Kumar S, Guo X, Trudgian DC, Mirzaei H, Tu BP (2013). Sulfur amino acids regulate translational capacity and metabolic homeostasis through modulation of tRNA thiolation. Cell 154(2): 416-429.
14. Wei FY, Suzuki T, Watanabe S, Kimura S, Kaitsuka T, Fujimura A, Matsui H, Atta M, Michiue H, Fontecave M, Yamagata K, Tomiza-wa K (2011). Deficit of tRNA(Lys) modification by Cdkal1 causes the development of type 2 diabetes in mice. J Clin Invest 121(9): 3598-3608.
15. 6A modification of tRNAs. Nucleic Acids Res.
16. Zinshteyn B, Gilbert WV (2013). Loss of a conserved tRNA anticodon modification perturbs cellular signaling. PLoS genetics 9(8): e1003675.
17. Natarajan K, Meyer MR, Jackson BM, Slade D, Roberts C, Hinnebusch AG, Marton MJ (2001). Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast. Mol Cell Biol 21(13): 4347-4368.
18. Cardenas ME, Cutler NS, Lorenz MC, Di Como CJ, Heitman J (1999). The TOR signaling cascade regulates gene expression in response to nutrients. Genes Dev 13(24): 3271-3279.
19. Jablonowski D, Taubert JE, Bar C, Stark MJ, Schaffrath R (2009). Distinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by rapamycin and zy-mocin. Eukaryot Cell 8(11): 1637-1647.
20. Jablonowski D, Fichtner L, Stark MJ, Schaffrath R (2004). The yeast elongator histone acetylase requires Sit4-dependent dephosphorylation for toxin-target capacity. Mol Biol Cell 15(3): 1459-1469.
21. Ibar C, Cataldo VF, Vasquez-Doorman C, Olguin P, Glavic A (2013). Drosophila p53-related protein kinase is required for PI3K/TOR pathway-dependent growth. Development 140(6): 1282-1291.
22. Damon JR, Pincus D, Ploegh HL (2014). tRNA thiolation links translation to stress responses in Saccharomyces cerevisiae. Mol Biol Cell. mbc. E14-06-1145
23. Rojas-Benitez D, Ibar C, Glavic A (2013). The Drosophila EKC/KEOPS complex: roles in protein synthesis homeostasis and animal growth. Fly (Austin) 7(3): 168-172.
24. Helm M, Alfonzo Juan D (2014). Posttranscriptional RNA modifications: playing metabolic games in a cell’s chemical legoland. Chem Biol 21(2): 174-185.
25. 2U in tRNA. Biochem Biophys Res Commun 454(3): 441-445.