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Volumn 3, Issue 1, 2015, Pages 27-35

Sofosbuvir, a significant paradigm change in hcv treatment

Author keywords

Direct acting antivirals; Ledipasvir; Sofosbuvir

Indexed keywords


EID: 84955473433     PISSN: 22250719     EISSN: 23108819     Source Type: Journal    
DOI: 10.14218/JCTH.2014.00041     Document Type: Review
Times cited : (70)

References (27)
  • 1
    • 84879290204 scopus 로고    scopus 로고
    • Direct-acting antivirals for the treatment of chronic hepatitis C: open issues and future perspectives
    • Chae HB, Park SM, Youn SJ. Direct-acting antivirals for the treatment of chronic hepatitis C: open issues and future perspectives. Scientific World Journal 2013;2013:704912. doi: 10.1155/2013/704912.
    • (2013) Scientific World Journal , vol.2013 , pp. 704912
    • Chae, HB1    Park, SM2    Youn, SJ.3
  • 2
    • 84896273933 scopus 로고    scopus 로고
    • Introduction to Hepatitis C Virus (HCV) Therapies Special Thematic Issue
    • Meanwell NA, Watkins WJ. Introduction to Hepatitis C Virus (HCV) Therapies Special Thematic Issue. J Med Chem 2014;57:1625–1626. doi: 10.1021/jm5000936.
    • (2014) J Med Chem , vol.57 , pp. 1625-1626
    • Meanwell, NA1    Watkins, WJ.2
  • 3
    • 84899047097 scopus 로고    scopus 로고
    • Sofosbuvir, a NS5B polymerase inhibitor in the treatment of hepatitis C: a review of its clinical potential
    • Stedman C. Sofosbuvir, a NS5B polymerase inhibitor in the treatment of hepatitis C: a review of its clinical potential. Therap Adv Gastroenterol 2014; 7:131–140. doi: 10.1177/1756283X13515825.
    • (2014) Therap Adv Gastroenterol , vol.7 , pp. 131-140
    • Stedman, C.1
  • 4
    • 84872050504 scopus 로고    scopus 로고
    • New therapeutic strategies in HCV: polymerase inhibitors
    • (Suppl)
    • Gerber L, Welzel TM, Zeuzem S. New therapeutic strategies in HCV: polymerase inhibitors. Liver Int 2013;33(Suppl):85–92. doi: 10.1111/liv.12068.
    • (2013) Liver Int , vol.33 , pp. 85-92
    • Gerber, L1    Welzel, TM2    Zeuzem, S.3
  • 5
    • 84879606466 scopus 로고    scopus 로고
    • New horizons in hepatitis C antiviral therapy with direct-acting antivirals
    • Aghemo A, De Francesco R. New horizons in hepatitis C antiviral therapy with direct-acting antivirals. Hepatology 2013;58:428–438. doi: 10.1002/hep.26371.
    • (2013) Hepatology , vol.58 , pp. 428-438
    • Aghemo, A1    De Francesco, R.2
  • 6
    • 84864011029 scopus 로고    scopus 로고
    • Structure of hepatitis C virus polymerase in complex with primer-template RNA
    • Mosley RT, Edwards TE, Murakami E, Lam AM, Grice RL, Du J, et al. Structure of hepatitis C virus polymerase in complex with primer-template RNA. J Virol 2012;86:6503–6511. doi: 10.1128/JVI.00386-12.
    • (2012) J Virol , vol.86 , pp. 6503-6511
    • Mosley, RT1    Edwards, TE2    Murakami, E3    Lam, AM4    Grice, RL5    Du, J6
  • 7
    • 84861109960 scopus 로고    scopus 로고
    • Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus
    • Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Niu C, Zennou V, et al. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrob Agents Chemother 2012;56:3359–3368. doi: 10.1128/AAC.00054-12.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 3359-3368
    • Lam, AM1    Espiritu, C2    Bansal, S3    Micolochick Steuer, HM4    Niu, C5    Zennou, V6
  • 8
    • 77957913871 scopus 로고    scopus 로고
    • Discovery of a beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus
    • Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, et al. Discovery of a beta-d-2'-deoxy-2'-alpha-fluoro-2'-beta-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. J Med Chem 2010;53:7202–7218. doi: 10.1021/jm100863x.
    • (2010) J Med Chem , vol.53 , pp. 7202-7218
    • Sofia, MJ1    Bao, D2    Chang, W3    Du, J4    Nagarathnam, D5    Rachakonda, S6
  • 9
    • 84887084522 scopus 로고    scopus 로고
    • Dancing with chemical formulae of antivirals: A panoramic view (Part 2)
    • De Clercq E. Dancing with chemical formulae of antivirals: A panoramic view (Part 2). Biochem pharmacol 2013;86:1397–1410. doi: 10.1016/j.bcp.2013.09.010.
    • (2013) Biochem pharmacol , vol.86 , pp. 1397-1410
    • De Clercq, E.1
  • 10
    • 84883404339 scopus 로고    scopus 로고
    • A novel promising therapeutic option against hepatitis C virus: an oral nucleotide NS5B polymerase inhibitor sofosbuvir
    • Gentile I, Borgia F, Buonomo AR, Castaldo G, Borgia G. A novel promising therapeutic option against hepatitis C virus: an oral nucleotide NS5B polymerase inhibitor sofosbuvir. Curr Med Chem 2013;20:3733–3742. doi: 10.2174/09298673113209990178.
    • (2013) Curr Med Chem , vol.20 , pp. 3733-3742
    • Gentile, I1    Borgia, F2    Buonomo, AR3    Castaldo, G4    Borgia, G.5
  • 11
    • 85179143808 scopus 로고    scopus 로고
    • accessed December 10, 2014
    • http://www.sovaldi.com/, accessed December 10, 2014.
  • 12
    • 84895757410 scopus 로고    scopus 로고
    • Population Pharmacokinetics of sofosbuvir and its major metabolite (GS-331007) in healthy and HCV-infected adult subjects
    • Kirby B, Gordi T, Symonds W, Mathias A. Population Pharmacokinetics of sofosbuvir and its major metabolite (GS-331007) in healthy and HCV-infected adult subjects. Hepatology 2013,58:746A–747A.
    • (2013) Hepatology , vol.58 , pp. 746A-747A
    • Kirby, B1    Gordi, T2    Symonds, W3    Mathias, A.4
  • 13
    • 85093892889 scopus 로고    scopus 로고
    • Clinical Pharmacology Workshop in HIV (and HCV) PResentations on New DAA’s oral HCV drugs in phase 3 development now
    • Amsterdam, Netherlands
    • Mathias A. Clinical Pharmacology Workshop in HIV (and HCV) PResentations on New DAA’s oral HCV drugs in phase 3 development now. Proceedings 14th International Workshop on Clinical Pharmacology of HIV Thearpy, 2013; Amsterdam, Netherlands.
    • (2013) Proceedings 14th International Workshop on Clinical Pharmacology of HIV Thearpy
    • Mathias, A.1
  • 14
    • 84888061539 scopus 로고    scopus 로고
    • Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection
    • Rodriguez-Torres M. Sofosbuvir (GS-7977), a pan-genotype, direct-acting antiviral for hepatitis C virus infection. Expert Rev Anti Infect Ther 2013;11: 1269–1279. doi: 10.1586/14787210.2013.855126.
    • (2013) Expert Rev Anti Infect Ther , vol.11 , pp. 1269-1279
    • Rodriguez-Torres, M.1
  • 15
    • 84873024272 scopus 로고    scopus 로고
    • The effect of Hepatic Impairment on the Pharmacokinetics and anti-viral activity of PSI-7977 in Hepatitis C infected subjects treated for seven days
    • Barcelona, Spain
    • Lawitz EJ. The effect of Hepatic Impairment on the Pharmacokinetics and anti-viral activity of PSI-7977 in Hepatitis C infected subjects treated for seven days. European Association for the Study of Liver Disease, 2012; Barcelona, Spain.
    • (2012) European Association for the Study of Liver Disease
    • Lawitz, EJ.1
  • 16
    • 84871213049 scopus 로고    scopus 로고
    • The Effect of Renal Impairment and End Stage Renal Disease on The Single-Dose pharmacoki-netics of PSI-7977
    • Cornpropst M, Denning J, Clemons D, Marbury T, Alcorn H. The Effect of Renal Impairment and End Stage Renal Disease on The Single-Dose pharmacoki-netics of PSI-7977. J Hepatol 2012;56:S433. doi: 10.1016/S0168-8278 (12)61113-1.
    • (2012) J Hepatol , vol.56 , pp. S433
    • Cornpropst, M1    Denning, J2    Clemons, D3    Marbury, T4    Alcorn, H.5
  • 18
    • 84881403455 scopus 로고    scopus 로고
    • Sofosbuvir for previously untreated chronic hepatitis C infection
    • Lawitz E, Gane EJ. Sofosbuvir for previously untreated chronic hepatitis C infection. N Engl J Med 2013;369:678–679. doi: 10.1056/NEJMc1307641.
    • (2013) N Engl J Med , vol.369 , pp. 678-679
    • Lawitz, E1    Gane, EJ.2
  • 19
    • 84883089005 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial
    • Osinusi A, Meissner EG, Lee YJ, Bon D, Heytens L, Nelson A, et al. Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial. JAMA 2013;310:804– 811. doi: 10.1001/jama.2013.109309.
    • (2013) JAMA , vol.310 , pp. 804-811
    • Osinusi, A1    Meissner, EG2    Lee, YJ3    Bon, D4    Heytens, L5    Nelson, A6
  • 20
    • 84877739274 scopus 로고    scopus 로고
    • Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options
    • Jacobson IM, Gordon SC, Kowdley KV, Yoshida EM, Rodriguez-Torres M, Sulkowski MS, et al. Sofosbuvir for Hepatitis C Genotype 2 or 3 in Patients without Treatment Options. N Engl J Med 2013;368:1867–1877. doi: 10.1056/NEJMoa1214854.
    • (2013) N Engl J Med , vol.368 , pp. 1867-1877
    • Jacobson, IM1    Gordon, SC2    Kowdley, KV3    Yoshida, EM4    Rodriguez-Torres, M5    Sulkowski, MS6
  • 21
  • 22
    • 84904570994 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin for hepatitis C in patients with HIV coinfection
    • Sulkowski MS, Naggie S, Lalezari J, Fessel WJ, Mounzer K, Shuhart M, et al. Sofosbuvir and ribavirin for hepatitis C in patients with HIV coinfection. JAMA 2014;312:353–361. doi: 10.1001/jama.2014.7734.
    • (2014) JAMA , vol.312 , pp. 353-361
    • Sulkowski, MS1    Naggie, S2    Lalezari, J3    Fessel, WJ4    Mounzer, K5    Shuhart, M6
  • 23
    • 84891143829 scopus 로고    scopus 로고
    • Sofosbuvir and Peginterferon alfa-2a/Ribavirin Treatment of naive Genotype 1–4 infected patients that are co-infected with HIV
    • ID Week, San Francisco, CA, USA
    • Rodriguez-Torres M, Rodriguez-Orengo J, Gaggar A, Shen G, Symonds B, McHutchison J, et al. Sofosbuvir and Peginterferon alfa-2a/Ribavirin Treatment of naive Genotype 1–4 infected patients that are co-infected with HIV. Conference Reports for NATAP, ID Week, 2013; San Francisco, CA, USA.
    • (2013) Conference Reports for NATAP
    • Rodriguez-Torres, M1    Rodriguez-Orengo, J2    Gaggar, A3    Shen, G4    Symonds, B5    McHutchison, J6
  • 24
    • 85179150769 scopus 로고    scopus 로고
    • accessed December 10, 2014
    • http://www.harvoni.com/, accessed December 10, 2014.
  • 25
    • 84898669547 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection
    • Afdhal N, Reddy KR, Nelson DR,, Lawitz E, Gordon SC, Schiff E, et al. Ledipasvir and sofosbuvir for previously treated HCV genotype 1 infection. N Engl J Med 2014;370:1483–1493. doi: 10.1056/NEJMoa1316366.
    • (2014) N Engl J Med , vol.370 , pp. 1483-1493
    • Afdhal, N1    Reddy, KR2    Nelson, DR3    Lawitz, E4    Gordon, SC5    Schiff, E6
  • 26
    • 84900339263 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection
    • Afdhal N, Zeuzem S, Kwo P, Chojkier M, Gitlin N, Puoti M, et al. Ledipasvir and sofosbuvir for untreated HCV genotype 1 infection. N Engl J Med 2014;370: 1889–1898. doi: 10.1056/NEJMoa1402454.
    • (2014) N Engl J Med , vol.370 , pp. 1889-1898
    • Afdhal, N1    Zeuzem, S2    Kwo, P3    Chojkier, M4    Gitlin, N5    Puoti, M6
  • 27
    • 84900326091 scopus 로고    scopus 로고
    • Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis
    • Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, et al. Ledipasvir and sofosbuvir for 8 or 12 weeks for chronic HCV without cirrhosis. N Engl J Med 2014;370:1879–1888. doi: 10.1056/NEJMoa1402355
    • (2014) N Engl J Med , vol.370 , pp. 1879-1888
    • Kowdley, KV1    Gordon, SC2    Reddy, KR3    Rossaro, L4    Bernstein, DE5    Lawitz, E6


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