Phase II/III weekly nab-paclitaxel plus gemcitabine or carboplatin versus gemcitabine/carboplatin as first-line treatment of patients with metastatic triple-negative breast cancer (the tnAcity study): Study protocol for a randomized controlled trial

Trials

Volumn 16, Issue 1, 2015, Pages

  Yardley, Denise A ^a   Brufsky, Adam ^b   Coleman, Robert E ^c   Conte, Pierfranco F ^d   Cortes, Javier ^e   Glück, Stefan ^f   Nabholtz, Jean Mark A ^g   O'Shaughnessy, Joyce ^h   Beck, Robert M ^f   Ko, Amy ^f   Renschler, Markus F ^f   Barton, Debora ^f   Harbeck, Nadia ⁱ  

^a SARAH CANNON RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^c WESTON PARK HOSPITAL   (United Kingdom)

^d UNIVERSITY OF PADOVA   (Italy)

^e VALL D HEBRON UNIVERSITY HOSPITAL   (Spain)

^f CELGENE CORPORATION   (United States)

^g Centre Regional de Lutte Contre le Cancer Jean Perrin   (France)

^h TEXAS ONCOLOGY   (United States)

ⁱ UNIVERSITY OF MUNICH   (Germany)

Author keywords

Abraxane; Carboplatin; Gemcitabine; Metastatic; Nab paclitaxel; Pick the winner trial design; tnAcity; Triple negative breast cancer

Indexed keywords

CARBOPLATIN; GEMCITABINE; PACLITAXEL; 130-NM ALBUMIN-BOUND PACLITAXEL; ALBUMINOID; ANTINEOPLASTIC AGENT; DEOXYCYTIDINE;

ARTICLE; BREAST METASTASIS; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MULTICENTER STUDY; MULTIPLE CYCLE TREATMENT; OPEN STUDY; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PHASE 2 CLINICAL TRIAL; PHASE 3 CLINICAL TRIAL; PROGRESSION FREE SURVIVAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SURVIVAL TIME; TRIPLE NEGATIVE BREAST CANCER; ANALOGS AND DERIVATIVES; CLINICAL PROTOCOL; CLINICAL TRIAL; COMPARATIVE STUDY; DISEASE COURSE; DRUG ADMINISTRATION; METASTASIS; METHODOLOGY; MORTALITY; PATHOLOGY; SURVIVAL ANALYSIS; TIME FACTOR; TREATMENT OUTCOME; TRIPLE NEGATIVE BREAST NEOPLASMS;

ALBUMINS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARBOPLATIN; CLINICAL PROTOCOLS; DEOXYCYTIDINE; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; DRUG ADMINISTRATION SCHEDULE; FEMALE; HUMANS; NEOPLASM METASTASIS; PACLITAXEL; RESEARCH DESIGN; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME; TRIPLE NEGATIVE BREAST NEOPLASMS;

EID: 84955361453     PISSN: None     EISSN: 17456215     Source Type: Journal    
DOI: 10.1186/s13063-015-1101-7     Document Type: Article

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