Subnormothermic ex vivo liver perfusion is a safe alternative to cold static storage for preserving standard criteria grafts

Liver Transplantation

Volumn 22, Issue 1, 2016, Pages 111-119

  Spetzler, Vinzent N ^a   Goldaracena, Nicolas ^a   Echiverri, Juan ^a   Kaths, J Moritz ^a   Louis, Kristine S ^a   Adeyi, Oyedele A ^b   Yip, Paul M ^b   Grant, David R ^a   Selzner, Nazia ^b   Selzner, Markus ^a  

^a TORONTO GENERAL HOSPITAL   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CASPASE 3; HYALURONIC ACID; UNIVERSITY OF WISCONSIN SOLUTION;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT INJURY; CONTROLLED STUDY; CRYOPRESERVATION; ENDOTHELIUM CELL; EX VIVO STUDY; GRAFT PRESERVATION; HISTOLOGY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER FUNCTION TEST; LIVER GRAFT; LIVER INJURY; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MALE; NONHUMAN; PRIORITY JOURNAL; SUBNORMOTHERMIC EX VIVO LIVER PERFUSION; ANIMAL; BILE DUCT; COMPARATIVE STUDY; EVALUATION STUDY; ORGAN PRESERVATION; PERFUSION; PHYSIOLOGY; PIG; PROCEDURES; TRANSPLANTATION;

ANIMALS; BILE DUCTS; ENDOTHELIAL CELLS; LIVER FUNCTION TESTS; LIVER TRANSPLANTATION; MALE; ORGAN PRESERVATION; PERFUSION; SWINE; TRANSPLANTS;

EID: 84955253456     PISSN: 15276465     EISSN: 15276473     Source Type: Journal    
DOI: 10.1002/lt.24340     Document Type: Article

References (46)

1. Vogel T, Brockmann JG, Coussios C, Friend PJ,. The role of normothermic extracorporeal perfusion in minimizing ischemia reperfusion injury. Transplant Rev (Orlando) 2012; 26: 156-162.
2. Hessheimer AJ, Fondevila C, García-Valdecasas JC,. Extracorporeal machine liver perfusion: are we warming up? Curr Opin Organ Transplant 2012; 17: 143-147.
3. Schön MR, Kollmar O, Wolf S, Schrem H, Matthes M, Akkoc N, et al., Liver transplantation after organ preservation with normothermic extracorporeal perfusion. Ann Surg 2001; 233: 114-123.
4. Brockmann J, Reddy S, Coussios C, Pigott D, Guirriero D, Hughes D, et al., Normothermic perfusion: a new paradigm for organ preservation. Ann Surg 2009; 250: 1-6.
5. Op den Dries S, Karimian N, Porte RJ,. Normothermic machine perfusion of discarded liver grafts. Am J Transplant 2013; 13: 2504.
6. Jamieson RW, Zilvetti M, Roy D, Hughes D, Morovat A, Coussios CC, Friend PJ,. Hepatic steatosis and normothermic perfusion-preliminary experiments in a porcine model. Transplantation 2011; 92: 289-295.
7. Liu Q, Nassar A, Farias K, Buccini L, Baldwin W, Mangino M, et al., Sanguineous normothermic machine perfusion improves hemodynamics and biliary epithelial regeneration in donation after cardiac death porcine livers. Liver Transpl 2014; 20: 987-999.
8. Boehnert MU, Yeung JC, Bazerbachi F, Knaak JM, Selzner N, McGilvray ID, et al., Normothermic acellular ex vivo liver perfusion reduces liver and bile duct injury of pig livers retrieved after cardiac death. Am J Transplant 2013; 13: 1441-1449.
9. Knaak JM, Spetzler VN, Goldaracena N, Boehnert MU, Bazerbachi F, Louis KS, et al., Subnormothermic ex vivo liver perfusion reduces endothelial cell and bile duct injury after donation after cardiac death pig liver transplantation. Liver Transpl 2014; 20: 1296-1305.
10. Fondevila C, Hessheimer AJ, Maathuis MH, Muñoz J, Taurá P, Calatayud D, et al., Superior preservation of DCD livers with continuous normothermic perfusion. Ann Surg 2011; 254: 1000-1007.
11. Spetzler VN, Goldaracena N, Selzner N, Selzner M,. Early clinical results using normothermic machine liver preservation. Curr Transpl Rep 2015; 2: 74-80.
12. Bojko B, Gorynski K, Gomez-Rios GA, Knaak JM, Machuca T, Cudjoe E, et al., Low invasive in vivo tissue sampling for monitoring biomarkers and drugs during surgery. Lab Invest 2014; 94: 586-594.
13. Bojko B, Gorynski K, Gomez-Rios GA, Knaak JM, Machuca T, Spetzler VN, et al., Solid phase microextraction fills the gap in tissue sampling protocols. Anal Chim Acta 2013; 803: 75-81.
14. Cortes M, Pareja E, García-Cañaveras JC, Donato MT, Montero S, Mir J, et al., Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction. J Hepatol 2014; 61: 564-574.
15. Thomas M, Deiters A,. MicroRNA miR-122 as a therapeutic target for oligonucleotides and small molecules. Curr Med Chem 2013; 20: 3629-3640.
16. Cypel M, Liu M, Rubacha M, Yeung JC, Hirayama S, Anraku M, et al., Functional repair of human donor lungs by IL-10 gene therapy. Sci Transl Med 2009; 1: 1-9.
17. Van Raemdonck D, Neyrinck A, Rega F, Devos T, Pirenne J,. Machine perfusion in organ transplantation: a tool for ex-vivo graft conditioning with mesenchymal stem cells? Curr Opin Organ Transplant 2013; 18: 24-33.
18. Knaak JM, Spetzler VN, Goldaracena N, Louis KS, Selzner N, Selzner M,. Technique of subnormothermic ex vivo liver perfusion for the storage, assessment, and repair of marginal liver grafts. J Vis Exp 2014; 90: e51419.
19. Zhang B, Calmus Y, Wen L, Sogni P, Lotersztajn S, Houssin D, Weill B,. Endothelin-1 induces liver vasoconstriction through both ETA and ETB receptors. J Hepatol 1997; 26: 1104-1110.
20. Nakai T, Tanimura H, Hirokawa F, Tamaki T,. Altered hepatic hemodynamics and improved liver function following intrahepatic vascular infusion of prostaglandin E1. J Gastroenterol 1998; 33: 362-367.
21. Winbladh A, Björnsson B, Trulsson L, Bojmar L, Sundqvist T, Gullstrand P, Sandström P,. N-acetyl cysteine improves glycogenesis after segmental liver ischemia and reperfusion injury in pigs. Scand J Gastroenterol 2012; 47: 225-236.
22. Vollmar B, Menger MD,. The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair. Physiol Rev 2009; 89: 1269-1339.
23. Tomiyama K, Ikeda A, Ueki S, Nakao A, Stolz DB, Koike Y, et al., Inhibition of Kupffer cell-mediated early proinflammatory response with carbon monoxide in transplant-induced hepatic ischemia/reperfusion injury in rats. Hepatology 2008; 48: 1608-1620.
24. Lee LY, Kaizu T, Toyokawa H, Zhang M, Ross M, Stolz DB, et al., Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats. Liver Transpl 2011; 17: 1457-1466.
25. Annecke T, Rehm M, Bruegger D, Kubitz JC, Kemming GI, Stoeckelhuber M, et al., Ischemia-reperfusion-induced unmeasured anion generation and glycocalyx shedding: sevoflurane versus propofol anesthesia. J Invest Surg 2012; 25: 162-168.
26. Deaciuc IV, Bagby GJ, Lang CH, Spitzer JJ,. Hyaluronic acid uptake by the isolated, perfused rat liver: an index of hepatic sinusoidal endothelial cell function. Hepatology 1993; 17: 266-272.
27. Soejima Y, Yanaga K, Wakiyama S, Nishizaki T, Yoshizumi T, Sugimachi K,. Serum hyaluronic acid as a reliable parameter of allograft viability in porcine liver transplantation. Hepatogastroenterology 1996; 43: 590-595.
28. Gown AM, Willingham MC,. Improved detection of apoptotic cells in archival paraffin sections: immunohistochemistry using antibodies to cleaved caspase 3. J Histochem Cytochem 2002; 50: 449-454.
29. Hansen T, Hollemann D, Pitton MB, Heise M, Hoppe-Lotichius M, Schuchmann M, et al., Histological examination and evaluation of donor bile ducts received during orthotopic liver transplantation - a morphological clue to ischemic-type biliary lesion? Virchows Arch 2012; 461: 41-48.
30. Pusztaszeri MP, Seelentag W, Bosman FT,. Immunohistochemical expression of endothelial markers CD31, CD34, von Willebrand factor, and Fli-1 in normal human tissues. J Histochem Cytochem 2006; 54: 385-395.
31. Fondevila C, Hessheimer AJ, Flores E, Vendrell M, Muñoz J, Escobar B, et al., Step-by-step guide for a simplified model of porcine orthotopic liver transplant. J Surg Res 2011; 167: e39-e45.
32. Fontes P, Lopez R, van der Plaats A, Vodovotz Y, Minervini M, Scott V, et al., Liver preservation with machine perfusion and a newly developed cell-free oxygen carrier solution under subnormothermic conditions. Am J Transplant 2015; 15: 381-394.
33. Minor T, Koetting M, Koetting M, Kaiser G, Efferz P, Lüer B, Paul A,. Hypothermic reconditioning by gaseous oxygen improves survival after liver transplantation in the pig. Am J Transplant 2011; 11: 2627-2634.
34. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ,. Kupffer cell activation and endothelial cell damage after storage of rat livers: effects of reperfusion. Hepatology 1991; 13: 83-95.
35. Gao W, Bentley RC, Madden JF, Clavien PA,. Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 1998; 27: 1652-1660.
36. van Golen RF, van Gulik TM, Heger M,. Mechanistic overview of reactive species-induced degradation of the endothelial glycocalyx during hepatic ischemia/reperfusion injury. Free Radic Biol Med 2012; 52: 1382-1402.
37. Caldwell-Kenkel JC, Currin RT, Tanaka Y, Thurman RG, Lemasters JJ,. Reperfusion injury to endothelial cells following cold ischemic storage of rat livers. Hepatology 1989; 10: 292-299.
38. Ikeda T, Yanaga K, Kishikawa K, Kakizoe S, Shimada M, Sugimachi K,. Ischemic injury in liver transplantation: difference in injury sites between warm and cold ischemia in rats. Hepatology 1992; 16: 454-461.
39. Peralta C, Jiménez-Castro MB, Gracia-Sancho J,. Hepatic ischemia and reperfusion injury: effects on the liver sinusoidal milieu. J Hepatol 2013; 59: 1094-1106.
40. Hashimoto K, Eghtesad B, Gunasekaran G, Fujiki M, Uso TD, Quintini C, et al., Use of tissue plasminogen activator in liver transplantation from donation after cardiac death donors. Am J Transplant 2010; 10: 2665-2672.
41. Sutton ME, op den Dries S, Koster MH, Lisman T, Gouw AS, Porte RJ,. Regeneration of human extrahepatic biliary epithelium: the peribiliary glands as progenitor cell compartment. Liver Int 2012; 32: 554-559.
42. Zhai Y, Petrowsky H, Hong JC, Busuttil RW, Kupiec-Weglinski JW,. Ischaemia-reperfusion injury in liver transplantation - from bench to bedside. Nat Rev Gastroenterol Hepatol 2013; 10: 79-89.
43. Sexton D, Medearis S, Liu Q, Iuppa G, Quintini C,. Preclinical foundation for normothermic machine liver preservation. Curr Transpl Rep 2015; 2: 68-73.
44. Sass G, Barikbin R, Tiegs G,. The multiple functions of heme oxygenase-1 in the liver. Z Gastroenterol 2012; 50: 34-40.
45. Ponnappa BC, Israel Y, Aini M, Zhou F, Russ R, Cao QN, et al., Inhibition of tumor necrosis factor alpha secretion and prevention of liver injury in ethanol-fed rats by antisense oligonucleotides. Biochem Pharmacol 2005; 69: 569-577.
46. Deng L, Liu G, Wu X, Wang Y, Tong M, Liu B, et al., Adipose derived mesenchymal stem cells efficiently rescue carbon tetrachloride-induced acute liver failure in mouse. ScientificWorldJournal 2014; 2014: 103643.