Combinatorial engineering of hybrid mevalonate pathways in Escherichia coli for protoilludene production

Microbial Cell Factories

Volumn 15, Issue 1, 2016, Pages

  Yang, Liyang ^a   Wang, Chonglong ^a   Zhou, Jia ^a,b   Kim, Seon Won ^a  

^a Gyeongsang National University   (South Korea)

^b HUAIYIN INSTITUTE OF TECHNOLOGY   (China)

Author keywords

coli; Escherichia; Homolog substitution; Mevalonate pathway; Protoilludene; Sequential order permutation

Indexed keywords

DIMETHYLALLYL DIPHOSPHATE; GERANYLTRANSFERASE; ISOPENTENYL DIPHOSPHATE; MEVALONIC ACID; PROTOILLUDENE; PROTOILLUDENE SYNTHASE; PYROPHOSPHATE; SESQUITERPENE DERIVATIVE; SYNTHETASE; UNCLASSIFIED DRUG; 3,3-DIMETHYLALLYL PYROPHOSPHATE; HEMITERPENE; ORGANOPHOSPHORUS COMPOUND;

ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BIOENGINEERING; BIOSYNTHESIS; COMBINATORIAL ENGINEERING; ESCHERICHIA COLI; GENE DOSAGE; MUSHROOM; NONHUMAN; OMPHALOTUS OLEARIUS; PLASMID; PROMOTER REGION; STAPHYLOCOCCUS AUREUS; METABOLISM;

ESCHERICHIA COLI; GERANYLTRANSTRANSFERASE; HEMITERPENES; MEVALONIC ACID; ORGANOPHOSPHORUS COMPOUNDS;

EID: 84955249209     PISSN: None     EISSN: 14752859     Source Type: Journal    
DOI: 10.1186/s12934-016-0409-7     Document Type: Article

References (19)

1. Reina M, Orihuela JC, Gonzalez-Coloma A, de Ines C, de la Cruz M, del Val GA, Torno JR, Fraga BM. Four illudane sesquiterpenes from coprinopsis episcopalis. Phytochemistry. 2004;65:381-5.
2. Wang XN, Shen JH, Du JC, Liu JK. Marasmane sesquiterpenes isolated from Russula foetens. J Antibiot. 2006;59:669-72 (Tokyo).
3. Bohnert M, Nutzmann HW, Schroeckh V, Horn F, Dahse HM, Brakhage AA, Hoffmeister D. Cytotoxic and antifungal activities of melleolide antibiotics follow dissimilar structure-activity relationships. Phytochemistry. 2014;105:101-8.
4. Schobert R, Knauer S, Seibt S, Biersack B. Anticancer active illudins: recent developments of a potent alkylating compound class. Curr Med Chem. 2011;18:790-807.
5. Wawrzyn GT. Discovery and characterization of sesquiterpenoid biosynthetic pathways from Basidiomycota. Retrieved from the University of Minnesota Digital Conservancy. http://hdl.handle.net/11299/162701.
6. Martin VJ, Pitera DJ, Withers ST, Newman JD, Keasling JD. Engineering a mevalonate pathway in Escherichia coli for production of terpenoids. Nat Biotechnol. 2003;21:796-802.
7. Engels B, Heinig U, Grothe T, Stadler M, Jennewein S. Cloning and characterization of an Armillaria gallica cDNA encoding protoilludene synthase, which catalyzes the first committed step in the synthesis of antimicrobial melleolides. J Biol Chem. 2011;286:6871-8.
8. Wawrzyn GT, Quin MB, Choudhary S, Lopez-Gallego F, Schmidt-Dannert C. Draft genome of Omphalotus olearius provides a predictive framework for sesquiterpenoid natural product biosynthesis in basidiomycota. Chem Biol. 2012;19:772-83.
9. Quin MB, Flynn CM, Wawrzyn GT, Choudhary S, Schmidt-Dannert C. Mushroom hunting by using bioinformatics: application of a predictive framework facilitates the selective identification of sesquiterpene synthases in basidiomycota. Chembiochem. 2013;14:2480-91.
10. Nowroozi FF, Baidoo EE, Ermakov S, Redding-Johanson AM, Batth TS, Petzold CJ, Keasling JD. Metabolic pathway optimization using ribosome binding site variants and combinatorial gene assembly. Appl Microbiol Biotechnol. 2014;98:1567-81.
11. Wang C, Yoon SH, Jang HJ, Chung YR, Kim JY, Choi ES, Kim SW. Metabolic engineering of Escherichia coli for alpha-farnesene production. Metab Eng. 2011;13:648-55.
12. Anthony JR, Anthony LC, Nowroozi F, Kwon G, Newman JD, Keasling JD. Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene. Metab Eng. 2009;11:13-9.
13. Lim HN, Lee Y, Hussein R. Fundamental relationship between operon organization and gene expression. Proc Natl Acad Sci USA. 2011;108:10626-31.
14. Yoon SH, Lee SH, Das A, Ryu HK, Jang HJ, Kim JY, Oh DK, Keasling JD, Kim SW. Combinatorial expression of bacterial whole mevalonate pathway for the production of beta-carotene in E. coli. J Biotechnol. 2009;140:218-26.
15. Nishizaki T, Tsuge K, Itaya M, Doi N, Yanagawa H. Metabolic engineering of carotenoid biosynthesis in Escherichia coli by ordered gene assembly in Bacillus subtilis. Appl Environ Microbiol. 2007;73:1355-61.
16. Anderson JC, Dueber JE, Leguia M, Wu GC, Goler JA, Arkin AP, Keasling JD. BglBricks: a flexible standard for biological part assembly. J Biol Eng. 2010;4:1.
17. Andreassi JL 2nd, Dabovic K, Leyh TS. Streptococcus pneumoniae isoprenoid biosynthesis is downregulated by diphosphomevalonate: an antimicrobial target. Biochemistry. 2004;43:16461-6.
18. Voynova NE, Rios SE, Miziorko HM. Staphylococcus aureus mevalonate kinase: isolation and characterization of an enzyme of the isoprenoid biosynthetic pathway. J Bacteriol. 2004;186:61-7.
19. Sambrook J, Russell DW. Molecular cloning: a laboratory manual. New York: Cold Spring Harbor Laboratory Press; 2001.