메뉴 건너뛰기




Volumn 34, Issue , 2016, Pages 125-132

Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids

Author keywords

Droplet microfluidics; Embryoid body; Endoderm; Heparin hydrogel; Microgel; Nodal

Indexed keywords

CELL ENGINEERING; CYTOLOGY; DROPS; FABRICATION; GELS; HYDROGELS; STEM CELLS; TISSUE; TISSUE ENGINEERING;

EID: 84955239755     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2016.01.012     Document Type: Article
Times cited : (102)

References (37)
  • 1
    • 34247226529 scopus 로고    scopus 로고
    • Gene function in mouse embryogenesis: Get set for gastrulation
    • P.P.L. Tam, and D.A.F. Loebel Gene function in mouse embryogenesis: get set for gastrulation Nat. Rev. Genet. 8 2007 368 381
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 368-381
    • Tam, P.P.L.1    Loebel, D.A.F.2
  • 2
    • 84867211807 scopus 로고    scopus 로고
    • Differentiation of definitive endoderm from mouse embryonic stem cells
    • P.T.W. Kim, and C.J. Ong Differentiation of definitive endoderm from mouse embryonic stem cells Results Probl. Cell Differ. 55 2012 303 319
    • (2012) Results Probl. Cell Differ. , vol.55 , pp. 303-319
    • Kim, P.T.W.1    Ong, C.J.2
  • 3
    • 34347221578 scopus 로고    scopus 로고
    • Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines
    • A. Soto-Gutierrez, N. Navarro-Alvarez, D. Zhao, J.D. Rivas-Carrillo, J. Lebkowski, N. Tanaka, and et al. Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines Nat. Protoc. 2 2007 347 356
    • (2007) Nat. Protoc. , vol.2 , pp. 347-356
    • Soto-Gutierrez, A.1    Navarro-Alvarez, N.2    Zhao, D.3    Rivas-Carrillo, J.D.4    Lebkowski, J.5    Tanaka, N.6
  • 4
    • 84872666175 scopus 로고    scopus 로고
    • Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation
    • J. Wilson, and T. McDevitt Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation Biotechnol. Bioeng. 110 2013 667 682
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 667-682
    • Wilson, J.1    McDevitt, T.2
  • 5
    • 72049093750 scopus 로고    scopus 로고
    • Microencapsulation and chondrogenic differentiation of human mesenchymal progenitor cells from subchondral bone marrow in Ca-alginate for cell injection
    • M. Endres, N. Wenda, H. Woehlecke, K. Neumann, J. Ringe, C. Erggelet, and et al. Microencapsulation and chondrogenic differentiation of human mesenchymal progenitor cells from subchondral bone marrow in Ca-alginate for cell injection Acta Biomater. 6 2010 436 444
    • (2010) Acta Biomater. , vol.6 , pp. 436-444
    • Endres, M.1    Wenda, N.2    Woehlecke, H.3    Neumann, K.4    Ringe, J.5    Erggelet, C.6
  • 6
    • 56449090986 scopus 로고    scopus 로고
    • The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering
    • Y.-S. Hwang, J. Cho, F. Tay, J.Y.Y. Heng, R. Ho, S.G. Kazarian, and et al. The use of murine embryonic stem cells, alginate encapsulation, and rotary microgravity bioreactor in bone tissue engineering Biomaterials 30 2009 499 507
    • (2009) Biomaterials , vol.30 , pp. 499-507
    • Hwang, Y.-S.1    Cho, J.2    Tay, F.3    Heng, J.Y.Y.4    Ho, R.5    Kazarian, S.G.6
  • 7
    • 36649006876 scopus 로고    scopus 로고
    • Differentiation of embryoid-body cells derived from embryonic stem cells into hepatocytes in alginate microbeads in vitro1
    • S. Fang, Y.-D. Qiu, L. Mao, X.-L. Shi, D.-C. Yu, and Y.-T. Ding Differentiation of embryoid-body cells derived from embryonic stem cells into hepatocytes in alginate microbeads in vitro1 Acta Pharmacol. Sin. 28 2007 1924 1930
    • (2007) Acta Pharmacol. Sin. , vol.28 , pp. 1924-1930
    • Fang, S.1    Qiu, Y.-D.2    Mao, L.3    Shi, X.-L.4    Yu, D.-C.5    Ding, Y.-T.6
  • 8
    • 84887534526 scopus 로고    scopus 로고
    • One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells
    • P. Agarwal, S. Zhao, P. Bielecki, W. Rao, J.K. Choi, Y. Zhao, J. Yu, and et al. One-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells Lab Chip 13 2013 4525 4533
    • (2013) Lab Chip , vol.13 , pp. 4525-4533
    • Agarwal, P.1    Zhao, S.2    Bielecki, P.3    Rao, W.4    Choi, J.K.5    Zhao, Y.6    Yu, J.7
  • 9
    • 84890589120 scopus 로고    scopus 로고
    • Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment
    • H.F. Chan, Y. Zhang, Y.-P. Ho, Y.-L. Chiu, Y. Jung, and K.W. Leong Rapid formation of multicellular spheroids in double-emulsion droplets with controllable microenvironment Sci. Rep. 3 2013 3462
    • (2013) Sci. Rep. , vol.3 , pp. 3462
    • Chan, H.F.1    Zhang, Y.2    Ho, Y.-P.3    Chiu, Y.-L.4    Jung, Y.5    Leong, K.W.6
  • 10
    • 84901011459 scopus 로고    scopus 로고
    • Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation
    • D.M. Headen, G. Aubry, H. Lu, and A.J. Garcia Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation Adv. Mater. (Deerfield Beach, Fla) 26 2014 3003 3008
    • (2014) Adv. Mater. (Deerfield Beach, Fla) , vol.26 , pp. 3003-3008
    • Headen, D.M.1    Aubry, G.2    Lu, H.3    Garcia, A.J.4
  • 11
    • 84879607867 scopus 로고    scopus 로고
    • Directed differentiation of size-controlled embryoid bodies towards endothelial and cardiac lineages in RGD-modified poly(ethylene glycol) hydrogels
    • L. Schukur, P. Zorlutuna, J.M. Cha, H. Bae, and A. Khademhosseini Directed differentiation of size-controlled embryoid bodies towards endothelial and cardiac lineages in RGD-modified poly(ethylene glycol) hydrogels Adv. Healthcare Mater. 2 2013 195 205
    • (2013) Adv. Healthcare Mater. , vol.2 , pp. 195-205
    • Schukur, L.1    Zorlutuna, P.2    Cha, J.M.3    Bae, H.4    Khademhosseini, A.5
  • 12
    • 84858251023 scopus 로고    scopus 로고
    • Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics
    • T. Rossow, J.A. Heyman, A.J. Ehrlicher, A. Langhoff, D.A. Weitz, R. Haag, and et al. Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics J. Am. Chem. Soc. 134 2012 4983 4989
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 4983-4989
    • Rossow, T.1    Heyman, J.A.2    Ehrlicher, A.J.3    Langhoff, A.4    Weitz, D.A.5    Haag, R.6
  • 13
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research
    • R.-Z. Lin, and H.-Y. Chang Recent advances in three-dimensional multicellular spheroid culture for biomedical research Biotechnol. J. 3 2008 1172 1184
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.-Z.1    Chang, H.-Y.2
  • 14
    • 60849086260 scopus 로고    scopus 로고
    • Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation
    • A.M. Bratt-Leal, R.L. Carpenedo, and T.C. McDevitt Engineering the embryoid body microenvironment to direct embryonic stem cell differentiation Biotechnol. Prog. 25 2009 43 51
    • (2009) Biotechnol. Prog. , vol.25 , pp. 43-51
    • Bratt-Leal, A.M.1    Carpenedo, R.L.2    McDevitt, T.C.3
  • 15
    • 84914697565 scopus 로고    scopus 로고
    • Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure
    • S. Jitraruch, A. Dhawan, R.D. Hughes, C. Filippi, D. Soong, C. Philippeos, and et al. Alginate microencapsulated hepatocytes optimised for transplantation in acute liver failure PLoS ONE 9 2014 e113609
    • (2014) PLoS ONE , vol.9 , pp. e113609
    • Jitraruch, S.1    Dhawan, A.2    Hughes, R.D.3    Filippi, C.4    Soong, D.5    Philippeos, C.6
  • 16
    • 78650394400 scopus 로고    scopus 로고
    • Generation of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid
    • C. Kim, S. Chung, Y.E. Kim, K.S. Lee, S.H. Lee, K.W. Oh, and et al. Generation of core-shell microcapsules with three-dimensional focusing device for efficient formation of cell spheroid Lab Chip 11 2011 246 252
    • (2011) Lab Chip , vol.11 , pp. 246-252
    • Kim, C.1    Chung, S.2    Kim, Y.E.3    Lee, K.S.4    Lee, S.H.5    Oh, K.W.6
  • 17
    • 84892834525 scopus 로고    scopus 로고
    • Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates
    • J.L. Wilson, M.A. Najia, R. Saeed, and T.C. McDevitt Alginate encapsulation parameters influence the differentiation of microencapsulated embryonic stem cell aggregates Biotechnol. Bioeng. 111 2014 618 631
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 618-631
    • Wilson, J.L.1    Najia, M.A.2    Saeed, R.3    McDevitt, T.C.4
  • 18
    • 84872666175 scopus 로고    scopus 로고
    • Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation
    • J.L. Wilson, and T.C. McDevitt Stem cell microencapsulation for phenotypic control, bioprocessing, and transplantation Biotechnol. Bioeng. 110 2013 667 682
    • (2013) Biotechnol. Bioeng. , vol.110 , pp. 667-682
    • Wilson, J.L.1    McDevitt, T.C.2
  • 19
    • 84901011459 scopus 로고    scopus 로고
    • Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation
    • D.M. Headen, G. Aubry, H. Lu, and A.J. Garcia Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation Adv. Mater. 26 19 2014 3003 3008
    • (2014) Adv. Mater. , vol.26 , Issue.19 , pp. 3003-3008
    • Headen, D.M.1    Aubry, G.2    Lu, H.3    Garcia, A.J.4
  • 20
    • 84911489252 scopus 로고    scopus 로고
    • Design of growth factor sequestering biomaterials
    • D.G. Belair, N.N. Le, and W.L. Murphy Design of growth factor sequestering biomaterials Chem. Commun. 50 2014 15651 15668
    • (2014) Chem. Commun. , vol.50 , pp. 15651-15668
    • Belair, D.G.1    Le, N.N.2    Murphy, W.L.3
  • 21
    • 77549088407 scopus 로고    scopus 로고
    • Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes
    • M. Kim, J.Y. Lee, C.N. Jones, A. Revzin, and G. Tae Heparin-based hydrogel as a matrix for encapsulation and cultivation of primary hepatocytes Biomaterials 31 2010 3596 3603
    • (2010) Biomaterials , vol.31 , pp. 3596-3603
    • Kim, M.1    Lee, J.Y.2    Jones, C.N.3    Revzin, A.4    Tae, G.5
  • 22
    • 67849094098 scopus 로고    scopus 로고
    • A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases
    • U. Freudenberg, A. Hermann, P.B. Welzel, K. Stirl, S.C. Schwarz, M. Grimmer, and et al. A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases Biomaterials 30 2009 5049 5060
    • (2009) Biomaterials , vol.30 , pp. 5049-5060
    • Freudenberg, U.1    Hermann, A.2    Welzel, P.B.3    Stirl, K.4    Schwarz, S.C.5    Grimmer, M.6
  • 23
    • 84938419865 scopus 로고    scopus 로고
    • Bioactive photodegradable hydrogel for cultivation and retrieval of embryonic stem cells
    • J. You, A. Haque, D.-S. Shin, K.J. Son, C. Siltanen, and A. Revzin Bioactive photodegradable hydrogel for cultivation and retrieval of embryonic stem cells Adv. Funct. Mater. 25 2015 4650 4656
    • (2015) Adv. Funct. Mater. , vol.25 , pp. 4650-4656
    • You, J.1    Haque, A.2    Shin, D.-S.3    Son, K.J.4    Siltanen, C.5    Revzin, A.6
  • 24
    • 34347348304 scopus 로고    scopus 로고
    • Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules
    • G. Tae, Y.J. Kim, W.I. Choi, M. Kim, P.S. Stayton, and A.S. Hoffman Formation of a novel heparin-based hydrogel in the presence of heparin-binding biomolecules Biomacromolecules 8 2007 1979 1986
    • (2007) Biomacromolecules , vol.8 , pp. 1979-1986
    • Tae, G.1    Kim, Y.J.2    Choi, W.I.3    Kim, M.4    Stayton, P.S.5    Hoffman, A.S.6
  • 25
    • 46849119584 scopus 로고    scopus 로고
    • Sustained release of human growth hormone from heparin-based hydrogel
    • W.I. Choi, M. Kim, G. Tae, and Y.H. Kim Sustained release of human growth hormone from heparin-based hydrogel Biomacromolecules 9 2008 1698 1704
    • (2008) Biomacromolecules , vol.9 , pp. 1698-1704
    • Choi, W.I.1    Kim, M.2    Tae, G.3    Kim, Y.H.4
  • 26
    • 33644809242 scopus 로고    scopus 로고
    • Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation
    • D.S. Benoit, and K.S. Anseth Heparin functionalized PEG gels that modulate protein adsorption for hMSC adhesion and differentiation Acta Biomater. 1 2005 461 470
    • (2005) Acta Biomater. , vol.1 , pp. 461-470
    • Benoit, D.S.1    Anseth, K.S.2
  • 27
    • 46849119584 scopus 로고    scopus 로고
    • Sustained release of human growth hormone from heparin-based hydrogel
    • W.I. Choi, M. Kim, G. Tae, and Y.H. Kim Sustained release of human growth hormone from heparin-based hydrogel Biomacromolecules 9 2008 1698 1704
    • (2008) Biomacromolecules , vol.9 , pp. 1698-1704
    • Choi, W.I.1    Kim, M.2    Tae, G.3    Kim, Y.H.4
  • 28
    • 78449253826 scopus 로고    scopus 로고
    • Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity
    • L. Shaoliang, S. Chisei, N. Naoko, N. Itsuko, O. Tetsuo, Y. Yoshiko, and et al. Activin A binds to perlecan through its pro-region that has heparin/heparan sulfate binding activity J. Biol. Chem. 285 2010 36645 36655
    • (2010) J. Biol. Chem. , vol.285 , pp. 36645-36655
    • Shaoliang, L.1    Chisei, S.2    Naoko, N.3    Itsuko, N.4    Tetsuo, O.5    Yoshiko, Y.6
  • 29
    • 84862212456 scopus 로고    scopus 로고
    • Droplet microfluidics for high-throughput biological assays
    • M.T. Guo, A. Rotem, J.A. Heyman, and D.A. Weitz Droplet microfluidics for high-throughput biological assays Lab Chip 12 2012 2146 2155
    • (2012) Lab Chip , vol.12 , pp. 2146-2155
    • Guo, M.T.1    Rotem, A.2    Heyman, J.A.3    Weitz, D.A.4
  • 30
    • 84858251023 scopus 로고    scopus 로고
    • Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics
    • T. Rossow, J.A. Heyman, A.J. Ehrlicher, A. Langhoff, D.A. Weitz, R. Haag, and et al. Controlled synthesis of cell-laden microgels by radical-free gelation in droplet microfluidics J. Am. Chem. Soc. 134 2012 4983 4989
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 4983-4989
    • Rossow, T.1    Heyman, J.A.2    Ehrlicher, A.J.3    Langhoff, A.4    Weitz, D.A.5    Haag, R.6
  • 31
    • 79954495556 scopus 로고    scopus 로고
    • Synthesis of monodisperse microparticles from non-Newtonian polymer solutions with microfluidic devices
    • A.R. Abate, M. Kutsovsky, S. Seiffert, M. Windbergs, L.F.V. Pinto, A. Rotem, and et al. Synthesis of monodisperse microparticles from non-newtonian polymer solutions with microfluidic devices Adv. Mater. 23 2011 1757 1760
    • (2011) Adv. Mater. , vol.23 , pp. 1757-1760
    • Abate, A.R.1    Kutsovsky, M.2    Seiffert, S.3    Windbergs, M.4    Pinto, L.F.V.5    Rotem, A.6
  • 32
    • 48949112425 scopus 로고    scopus 로고
    • Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm
    • N. Shiraki, T. Yoshida, K. Araki, A. Umezawa, Y. Higuchi, H. Goto, and et al. Guided differentiation of embryonic stem cells into Pdx1-expressing regional-specific definitive endoderm Stem Cells (Dayton, Ohio) 26 2008 874 885
    • (2008) Stem Cells (Dayton, Ohio) , vol.26 , pp. 874-885
    • Shiraki, N.1    Yoshida, T.2    Araki, K.3    Umezawa, A.4    Higuchi, Y.5    Goto, H.6
  • 33
    • 84904248056 scopus 로고    scopus 로고
    • Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum
    • K. Teo Adrian Kee, A. Valdez Ivan, E. Dirice, and N. Kulkarni Rohit Comparable generation of activin-induced definitive endoderm via additive Wnt or BMP signaling in absence of serum Stem Cell Rep. 3 2014 5 14
    • (2014) Stem Cell Rep. , vol.3 , pp. 5-14
    • Teo Adrian Kee, K.1    Valdez Ivan, A.2    Dirice, E.3    Kulkarni Rohit, N.4
  • 34
    • 84872056543 scopus 로고    scopus 로고
    • Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation
    • A.E. Chen, M. Borowiak, R.I. Sherwood, A. Kweudjeu, and D.A. Melton Functional evaluation of ES cell-derived endodermal populations reveals differences between Nodal and Activin A-guided differentiation Development 140 2013 675 686
    • (2013) Development , vol.140 , pp. 675-686
    • Chen, A.E.1    Borowiak, M.2    Sherwood, R.I.3    Kweudjeu, A.4    Melton, D.A.5
  • 35
    • 79953700252 scopus 로고    scopus 로고
    • Bottom-up signaling from HGF-containing surfaces promotes hepatic differentiation of mesenchymal stem cells
    • M. Ghaedi, N. Tuleuova, M.A. Zern, J. Wu, and A. Revzin Bottom-up signaling from HGF-containing surfaces promotes hepatic differentiation of mesenchymal stem cells Biochem. Biophys. Res. Commun. 407 2011 295 300
    • (2011) Biochem. Biophys. Res. Commun. , vol.407 , pp. 295-300
    • Ghaedi, M.1    Tuleuova, N.2    Zern, M.A.3    Wu, J.4    Revzin, A.5
  • 36
    • 77953811258 scopus 로고    scopus 로고
    • Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury
    • C.N. Jones, N. Tuleuova, J.Y. Lee, E. Ramanculov, A.H. Reddi, M.A. Zern, and et al. Cultivating hepatocytes on printed arrays of HGF and BMP7 to characterize protective effects of these growth factors during in vitro alcohol injury Biomaterials 31 2010 5936 5944
    • (2010) Biomaterials , vol.31 , pp. 5936-5944
    • Jones, C.N.1    Tuleuova, N.2    Lee, J.Y.3    Ramanculov, E.4    Reddi, A.H.5    Zern, M.A.6
  • 37
    • 36549035731 scopus 로고    scopus 로고
    • Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo
    • S. Oki, R. Hashimoto, Y. Okui, M. Shen, E. Mekada, H. Otani, and et al. Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo Development 134 2007 3893 3904
    • (2007) Development , vol.134 , pp. 3893-3904
    • Oki, S.1    Hashimoto, R.2    Okui, Y.3    Shen, M.4    Mekada, E.5    Otani, H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.