Lifelong leukocyte telomere dynamics and survival in a free-living mammal

Aging Cell

Volumn 15, Issue 1, 2016, Pages 140-148

  Fairlie, Jennifer ^a   Holland, Rebecca ^a   Pilkington, Jill G ^a   Pemberton, Josephine M ^a   Harrington, Lea ^b   Nussey, Daniel H ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Early life environment; Longitudinal; Mortality; Natural selection; Soay sheep; Telomere length

Indexed keywords

ADULT; ARTICLE; CONTROLLED STUDY; DOMESTIC SHEEP; FEMALE; LEUKOCYTE TELOMERE LENGTH; LIFESPAN; LONGEVITY; MAMMAL; MORTALITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SURVIVAL; TELOMERE HOMEOSTASIS; AGING; ANIMAL; BLOOD; CYTOLOGY; LEUKOCYTE; METABOLISM; PHYSIOLOGY; SHEEP; TELOMERE;

BIOLOGICAL MARKER;

AGING; ANIMALS; BIOMARKERS; LEUKOCYTES; LONGEVITY; SHEEP; TELOMERE; TELOMERE HOMEOSTASIS;

EID: 84955216357     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12417     Document Type: Article

References (45)

1. Aubert G, Lansdorp PM (2008) Telomeres and aging. Physiol. Rev. 88, 557-579.
2. Aviv A (2008) The epidemiology of human telomeres: faults and promises. J. Gerontol. A Biol. Sci. Med. Sci. 63, 979-983.
3. Baerlocher GM, Mak J, Röth A, Rice KS, Lansdorp PM (2003) Telomere shortening in leukocyte subpopulations from baboons. J. Leukoc. Biol. 73, 289-296.
4. Barrett ELB, Richardson DS (2011) Sex differences in telomeres and lifespan. Aging Cell 10, 913-921.
5. Barrett ELB, Burke TA, Hammers M, Komdeur J, Richardson DS (2013) Telomere length and dynamics predict mortality in a wild longitudinal study. Mol. Ecol. 22, 249-259.
6. Bauch C, Becker PH, Verhulst S (2013) Telomere length reflects phenotypic quality and costs of reproduction in a long-lived seabird. Proc. R. Soc. B 280, 20122540.
7. Beirne C, Delahay R, Hares M, Young A (2014) Age-related declines and disease-associated variation in immune cell telomere length in a wild mammal. PLoS ONE 9, e108964.
8. Benetos A, Kark JD, Susser E, Kimura M, Sinnreich R, Chen W, Steenstrup T, Christensen K, Herbig U, von Bornemann Hjelmborg J, Berenson GS, Labat S, Aviv A (2013) Tracking and fixed ranking of leukocyte telomere length across the adult life course. Aging Cell 12, 615-621.
9. Bize P, Criscuolo F, Metcalfe NB, Nasir L, Monaghan P (2009) Telomere dynamics rather than age predict life expectancy in the wild. Proc. R. Soc. B 276, 1679-1683.
10. Cawthon RM (2002) Telomere measurement by quantitative PCR. Nucleic Acids Res. 30, e47.
11. Cech TR (2004) Beginning to understand the end of the chromosome. Cell 116, 273-279.
12. Clutton-Brock TH, Pemberton JM (2004) Soay Sheep: Dynamics and Selection in an Island Population. Cambridge: Cambridge University Press.
13. Colchero F, Clark JS (2012) Bayesian inference on age-specific survival for censored and truncated data. J. Anim. Ecol. 81, 139-149.
14. Coulson T, Catchpole EA, Albon SD, Morgan BJT, Pemberton JM, Clutton-Brock TH, Crawley MJ, Grenfell BT (2001) Age, sex, density, winter weather, and population crashes in Soay sheep. Science 292, 1528-1531.
15. Daniali L, Benetos A, Susser E, Kark JD, Labat C, Kimura M, Desai K, Granick M, Aviv A (2013) Telomeres shorten at equivalent rates in somatic tissues of adults. Nat. Commun. 4, 1597.
16. Davis T, Kipling D (2005) Telomeres and telomerase biology in vertebrates: progress towards a non-human model for replicative senescence and ageing. Biogerontology 6, 371-385.
17. De Lange T (2004) T-loops and the origin of telomeres. Nat. Rev. Mol. Cell Biol. 5, 323-329.
18. Doksani Y, de Lange T (2014) The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harb. Perspect. Biol. 6, a0165076.
19. Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD, Cawthon RM (2004) Accelerated telomere shortening in response to life stress. PNAS 101, 17312-17315.
20. Falconer DS, Mackay TFC (1996) Introduction to Quantitative Genetics, 4th edn. London: Prentice Hall.
21. Haussmann MF, Longenecker AS, Marchetto NM, Juliano SA, Bowden RM (2012) Embryonic exposure to corticosterone modifies the juvenile stress response, oxidative stress and telomere length. Proc. R. Soc. B 279, 1447-1456.
22. Hayward AD, Wilson AJ, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB (2013) Reproductive senescence in female Soay sheep: variation across traits and contributions of individual ageing and selective disappearance. Funct. Ecol. 27, 184-195.
23. Heidinger BJ, Blount JD, Boner W, Griffiths K, Metcalfe NB, Monaghan P (2012) Telomere length in early life predicts lifespan. PNAS 109, 1743-1748.
24. Izzo C, Hamer DJ, Bertozzi T, Donnellan SC, Gillanders BM (2011) Telomere length and age in pinnipeds: the endangered Australian sea lion as a case study. Mar. Mamm. Sci. 27, 841-851.
25. de Jesus BB, Schneeberger K, Vera E, Tejera A, Harley CB, Blasco MA (2011) The telomerase activator TA65 elongates short telomeres and increases health span of adult/old mice without increasing cancer incidence. Aging Cell 10, 604-621.
26. 2 GLMM to random slopes models. Methods Ecol. Evol. 5, 944-946.
27. Kimura M, Stone RC, Hunt SC, Skurnick J, Lu XB, Cao XJ, Harley CB, Aviv A (2010) Measurement of telomere length by the Southern blot analysis of terminal restriction fragment lengths. Nat. Protoc. 5, 1596-1607.
28. Lewin N, Treidel LA, Holekamp KE, Place NJ, Haussmann MF (2015) Socioecological variables predict telomere length in wild spotted hyenas. Biol. Lett. 11, 20140991.
29. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153, 1194-1217.
30. Martin-Ruiz CM, Gussekloo J, van Heemst D, von Zglinicki T, Westendorp RGJ (2005) Telomere length in white blood cells is not associated with morbidity or mortality in the oldest old: a population-based study. Aging Cell 4, 287-290.
31. Mather KA, Jorm AF, Parslow RA, Christensen H (2011) Is telomere length a biomarker of aging? A review. J. Gerontol. A 66, 202-213.
32. Monaghan P (2014) Organismal stress, telomeres and life histories. J. Exp. Biol. 217, 57-66.
33. Monaghan P, Haussmann MF (2006) Do telomere dynamics link lifestyle and lifespan?. Trends Ecol. Evol. 21, 47-53.
34. Muezzinler A, Zaineddin AK, Brenner H (2013) A systematic review of leukocyte telomere length and age in adults. Ageing Res. Rev. 12, 509-519.
35. Nettle D, Monaghan P, Gillespie R, Brilot B, Bedford T, Bateson M (2015) An experimental demonstration that early-life competitive disadvantage accelerates telomere loss. Proc. R. Soc. B 282, 20141610.
36. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45.
37. R Development Core Team (2008). R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing: Vienna, Austria. ISBN 3-900051-07-0, URL: http://www.R-project.org.
38. Rebke M, Coulson T, Becker PH, Vaupel JW (2010) Reproductive improvement and senescence in a long-lived bird. PNAS 107, 7841-7846.
39. Ruijter JM, Ramakers C, Hoogaars WMH, Karlen Y, Bakker O, van den Hoff MJB, Moorman AFM (2009) Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data. Nucleic Acids Res. 37, e45.
40. Shalev I (2012) Early life stress and telomere length: investigating the connection and possible mechanisms. BioEssays 34, 943-952.
41. Svensson U, Nordfjall K, Baird DM, Roger L, Osterman P, Hellenius M-L, Roos G (2011) Blood cell telomere length is a dynamic feature. PLoS ONE 6, e21485.
42. Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA (2012) The rate of increase of short telomeres predicts longevity in mammals. Cell Rep. 2, 732-737.
43. Vera E, de Jesus BB, Foronda M, Flores JM, Blasco MA (2013) Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity. PLoS ONE 8, e53760.
44. Verhulst S, Aviv A, Benetos A, Berenson GS, Kark JD (2013) Do leukocyte telomere length dynamics depend on baseline telomere length? An analysis that corrects for regression to the mean. Eur. J. Epidemiol. 28, 859-866.
45. Weng NP (2012) Telomeres and immune competency. Curr. Opin. Immunol. 24, 470-475.