Contact allergy to chlorhexidine in a tertiary dermatology clinic in Denmark

Contact Dermatitis

Volumn 74, Issue 1, 2016, Pages 29-36

  Opstrup, Morten S ^a   Johansen, Jeanne D ^a   Zachariae, Claus ^a   Garvey, Lene H ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

chlorhexidine; chlorhexidine allergy; chlorhexidine contact allergy; chlorhexidine contact dermatitis; chlorhexidine diacetate; chlorhexidine digluconate; contact allergy; contact dermatitis

Indexed keywords

CHLORHEXIDINE; CHLORHEXIDINE GLUCONATE; DERMATOLOGICAL AGENT; TOPICAL ANTIINFECTIVE AGENT;

ADULT; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; DENMARK; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, OCCUPATIONAL; DERMATOLOGY; FEMALE; HUMAN; MALE; OCCUPATIONAL EXPOSURE; OUTPATIENT DEPARTMENT; PATCH TEST; PREVALENCE; RETROSPECTIVE STUDY;

ADULT; AMBULATORY CARE FACILITIES; ANTI-INFECTIVE AGENTS, LOCAL; CHLORHEXIDINE; DENMARK; DERMATITIS, ALLERGIC CONTACT; DERMATITIS, OCCUPATIONAL; DERMATOLOGIC AGENTS; DERMATOLOGY; FEMALE; HUMANS; MALE; OCCUPATIONAL EXPOSURE; PATCH TESTS; PREVALENCE; RETROSPECTIVE STUDIES;

EID: 84955194577     PISSN: 01051873     EISSN: 16000536     Source Type: Journal    
DOI: 10.1111/cod.12487     Document Type: Article

References (24)

1. Lim K-S, Kam P C,. Chlorhexidine-pharmacology and clinical applications. Anaesth Intensive Care 2008: 36: 502-512.
2. Darouiche R O, Wall M J, Itani K M F, et al., Chlorhexidine-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 2010: 362: 18-26.
3. Opstrup M, Johansen J, Garvey L,. Chlorhexidine allergy: sources of exposure in the health-care setting. Br J Anaesth 2015: 114: 704-705.
4. Odedra K M, Farooque S,. Chlorhexidine: an unrecognised cause of anaphylaxis. Postgrad Med J 2014: 90: 709-714.
5. Liippo J, Kousa P, Lammintausta K,. The relevance of chlorhexidine contact allergy. Contact Dermatitis 2011: 64: 229-234.
6. Opstrup M S, Johansen J D, Bossi R, et al., Chlorhexidine in cosmetic products-a market survey. Contact Dermatitis 2015: 72: 55-58.
7. Silvestri D L, McEnery-Stonelake M,. Chlorhexidine: uses and adverse reactions. Dermatitis 2013: 24: 112-118.
8. Hasan T, Rantanen T, Alanko K, et al., Patch test reactions to cosmetic allergens in 1995-1997 and 2000-2002 in Finland-a multicentre study. Contact Dermatitis 2005: 53: 40-45.
9. Dastychová E, Necas M, Vasku V,. Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. Acta Dermatovenerol Alp Panonica Adriat 2008: 17: 61-68.
10. Bechgaard E, Ploug E, Hjorth N,. Contact sensitivity to chlorhexidine? Contact Dermatitis 1985: 13: 53-55.
11. Osmundsen P,. Contact dermatitis to chlorhexidine. Contact Dermatitis 1982: 8: 81-83.
12. Lasthein Andersen B, Brandrup F,. Contact dermatitis from chlorhexidine. Contact Dermatitis 1985: 13: 307-309.
13. Perrenoud D, Bircher A, Hunziker T, et al., Frequency of sensitization to 13 common preservatives in Switzerland. Contact Dermatitis 1994: 30: 276-279.
14. Goon A T, White I R, Rycroft R J, McFadden J P,. Allergic contact dermatitis from chlorhexidine. Dermatitis 2004: 15: 45-47.
15. Garvey L H, Krøigaard M, Poulsen L K, et al., IgE-mediated allergy to chlorhexidine. J Allergy Clin Immunol 2007: 120: 409-415.
16. Nakonechna A, Dore P, Dixon T, et al., Immediate hypersensitivity to chlorhexidine is increasingly recognised in the United Kingdom. Allergol Immunopathol 2014: 42: 44-49.
17. Lauerma A I,. Simultaneous immediate and delayed hypersensitivity to chlorhexidine dugluconate. Contact Dermatitis 2001: 44: 59.
18. Bergqvist-Karlsson A,. Delayed and immediate-type hypersensitivity to chlorhexidine. Contact Dermatitis 1988: 18: 84-88.
19. Ebo D G, Stevens W J, Bridts C H, Matthieu L,. Contact allergic dermatitis and life-threatening anaphylaxis to chlorhexidine. J Allergy Clin Immunol 1998: 101: 128-129.
20. Sigma Aldrich. Product catalogue. Available at: http://www.sigmaaldrich.com/catalog/search?term=chlorhexidine&interface=All&N=0&mode=match&20partialmax&lang=en®ion=DK&focus=product (last accessed 15 October 2015).
21. European Commision. CosIng. Available at: http://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details-v2&id=28789 (last accessed 30 November 2015).
22. Knudsen B, Avnstorp C,. Chlorhexidine gluconate and acetate in patch testing. Contact Dermatitis 1991: 24: 45-49.
23. Brockow K, Garvey L H, Aberer W, et al., Skin test concentrations for systemically administered drugs-an ENDA/EAACI Drug Allergy Interest Group position paper. Allergy 2013: 68: 702-712.
24. Opstrup M S, Malling H-J, Krøigaard M, et al., Standardized testing with chlorhexidine in perioperative allergy-a large single-centre evaluation. Allergy 2014: 69: 1390-1396.