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Angewandte Chemie - International Edition

Volumn 54, Issue 50, 2015, Pages 15156-15159

Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability

(6) Edgeworth, Matthew J b Phillips, Jonathan J c Lowe, David C b Kippen, Alistair D b Higazi, Daniel R b Scrivens, James H a

a UNIVERSITY OF WARWICK (United Kingdom)

b MEDIMMUNE (United States)

c UNIVERSITY OF CAMBRIDGE (United Kingdom)

Author keywords

antibodies; hydrogen exchange; immunoglobulin; ion mobility; mass spectrometry

Indexed keywords

ION EXCHANGE; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; PROTEINS; SPECTROMETRY; STABILITY; THERMODYNAMIC STABILITY; THERMODYNAMICS;

ANTIBODY THERAPEUTICS; HYDROGEN EXCHANGE; HYDROGEN/DEUTERIUM EXCHANGE; IMMUNOGLOBULIN; ION MOBILITY; ION MOBILITY-MASS SPECTROMETRY; MONOCLONAL ANTIBODIES (MABS); THERAPEUTIC PROTEIN;

ANTIBODIES;

IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

CHEMISTRY; DEUTERIUM HYDROGEN EXCHANGE; HUMAN; MASS SPECTROMETRY; PROTEIN CONFORMATION; THERMODYNAMICS;

ANTIBODIES, MONOCLONAL; DEUTERIUM EXCHANGE MEASUREMENT; HUMANS; IMMUNOGLOBULIN G; MASS SPECTROMETRY; PROTEIN CONFORMATION; THERMODYNAMICS;

EID: 84955192386 PISSN: 14337851 EISSN: 15213773 Source Type: Journal
DOI: 10.1002/anie.201507223 Document Type: Article

Times cited : (25)

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