Endocrine disruptors in 2015: Epigenetic transgenerational inheritance

Nature Reviews Endocrinology

Volumn 12, Issue 2, 2016, Pages 68-

  Skinner, Michael K ^a  

^a WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOSTERONE; ENDOCRINE DISRUPTOR; PHTHALIC ACID; UNTRANSLATED RNA; VINCLOZOLIN; OXAZOLE DERIVATIVE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER;

DNA METHYLATION; ENVIRONMENTAL EXPOSURE; EPIGENETIC TRANSGENERATIONAL INHERITANCE; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; GENETIC DISORDER; HISTONE MODIFICATION; HUMAN; HYPOSPADIAS; INHERITANCE; NONHUMAN; PHENOTYPE; PHENOTYPIC VARIATION; PRENATAL EXPOSURE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; REVIEW; SEX DETERMINATION; CHEMICALLY INDUCED; DRUG EFFECTS; FEMALE; GENETIC EPIGENESIS; GENETICS; GERM CELL; MALE; METABOLISM; MUTATION; PREGNANCY; SPERMATOZOON;

DIETHYLHEXYL PHTHALATE; ENDOCRINE DISRUPTORS; EPIGENESIS, GENETIC; FEMALE; GENE EXPRESSION; GERM CELLS; HUMANS; HYPOSPADIAS; MALE; MUTATION; OXAZOLES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RNA, UNTRANSLATED; SPERMATOZOA;

EID: 84955190942     PISSN: 17595029     EISSN: 17595037     Source Type: Journal    
DOI: 10.1038/nrendo.2015.206     Document Type: Review

References (9)

1. Skinner, M. K. Endocrine disruptor induction of epigenetic transgenerational inheritance of disease. Mol. Cell. Endocrinol. 398, 4-12 (2014).
2. Anway, M. D., Cupp, A. S., Uzumcu, M. & Skinner, M. K. Epigenetic transgenerational actions of endocrine disruptors and male fertility. Science 308, 1466-1469 (2005).
3. Kalfa, N. et al. Is hypospadias associated with prenatal exposure to endocrine disruptors? A French collaborative controlled study of a cohort of 300 consecutive children without genetic defect. Eur. Urol. 68, 1023-1030 (2015).
4. Swan, S. H. Environmental phthalate exposure in relation to reproductive outcomes and other health endpoints in humans. Environ. Res. 108, 177-184 (2008).
5. Quinnies, K. M., Doyle, T. J., Kim, K. H. & Rissman, E. F. Transgenerational effects of di-(2-ethylhexyl) phthalate (DEHP) on stress hormones and behavior. Endocrinology 156, 3077-3083 (2015).
6. Dias, B. G., Maddox, S. A., Klengel, T. & Ressler, K. J. Epigenetic mechanisms underlying learning and the inheritance of learned behaviors. Trends Neurosci. 38, 96-107 (2015).
7. Brieno-Enriquez, M. A. et al. Exposure to endocrine disruptor induces transgenerational epigenetic deregulation of microRNAs in primordial germ cells. PLoS ONE 10, e0124296 (2015).
8. Tang, W. W. et al. A unique gene regulatory network resets the human germline epigenome for development. Cell 161, 1453-1467 (2015).
9. Skinner, M. K., Guerrero-Bosagna, C. & Haque, M. M. Environmentally induced epigenetic transgenerational inheritance of sperm epimutations promote genetic mutations. Epigenetics 10, 762-771 (2015).