Characteristics of respiratory syncytial virus-induced bronchiolitis co-infection with Mycoplasma pneumoniae and add-on therapy with montelukast

World Journal of Pediatrics

Volumn 12, Issue 1, 2016, Pages 88-95

  Wu, Sheng Hua ^a   Chen, Xiao Qing ^b   Kong, Xia ^a   Yin, Pei Ling ^a   Dong, Ling ^a   Liao, Pei Yuan ^c   Wu, Jia Ming ^d  

^a THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

^b Jiangsu Women and Children's Hospital   (China)

^c Central People's Hospital of Tengzhou   (China)

^d Qidong People's Hospital   (China)

Author keywords

bronchiolitis; leukotrienes; montelukast; Mycoplasma pneumoniae; respiratory syncytial virus

Indexed keywords

EOSINOPHIL CATIONIC PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; LEUKOTRIENE B4; LEUKOTRIENE C4; LIPOXIN A; LIPOXIN B; MONTELUKAST; PLACEBO; ACETIC ACID DERIVATIVE; LEUKOTRIENE RECEPTOR BLOCKING AGENT; QUINOLINE DERIVATIVE;

ADD ON THERAPY; ARTICLE; BLOOD ANALYSIS; BRONCHIOLITIS; CHILD; CONTROLLED STUDY; CRYING; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DYSPHORIA; EOSINOPHIL COUNT; FEVER; HOSPITALIZATION; HUMAN; HUMAN RESPIRATORY SYNCYTIAL VIRUS; HYPERACTIVITY; MAJOR CLINICAL STUDY; MIXED INFECTION; MYCOPLASMA PNEUMONIA; MYCOPLASMA PNEUMONIAE; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; RECURRENT DISEASE; RESPIRATORY SYNCYTIAL VIRUS INFECTION; SIDE EFFECT; THORAX RADIOGRAPHY; WHEEZING; COMBINATION DRUG THERAPY; COMPLICATION; FEMALE; INFANT; MALE; PROSPECTIVE STUDY; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; VIROLOGY;

ACETATES; BRONCHIOLITIS; COINFECTION; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; INFANT; LEUKOTRIENE ANTAGONISTS; MALE; PNEUMONIA, MYCOPLASMA; PROSPECTIVE STUDIES; QUINOLINES; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS;

EID: 84955179145     PISSN: 17088569     EISSN: 18670687     Source Type: Journal    
DOI: 10.1007/s12519-015-0024-4     Document Type: Article

References (32)

1. Goodman D. Inflammatory disorders of the small airways. In: Kliegman RM, Behrman RE, Jenson HB, eds. Nelson Textbook of Pediatrics, 19th ed. Philadelphia: Saunders Elsevier, 2009: 1415–1417.
2. Sigurs N, Gustafsson PM, Bjarnason R, Lundberg F, Schmidt S, Sigurbergsson F, et al. Severe respiratory syncytial virus bronchiolitis in infancy and asthma and allergy at age 13. Am J Respir Crit Care Med 2005;171:137–141.
3. Hong SJ. The Role of Mycoplasma pneumoniae Infection in Asthma. Allergy Asthma Immunol Res 2012;4:59–61.
4. Cha SI, Shin KM, Kim M, Yoon WK, Lee SY, Kim CH, et al. Mycoplasma pneumoniae bronchiolitis in adults: clinicoradiologic features and clinical course. Scand J Infect Dis 2009;41:515–519.
5. Choi EH, Lee HJ, Yoo T, Chanock SJ. A common haplotype of interleukin-4 gene IL4 is associated with severe respiratory syncytial virus disease in Korean children. J Infect Dis 2002;186:1207–1211.
6. Montella S, Maglione M, De Stefano S, Manna A, Di Giorgio A, Santamaria F. Update on leukotriene receptor antagonists in preschool children wheezing disorders. Ital J Pediatr 2012;38:29.
7. Wu SH, Yin PL, Zhang YM, Tao HX. Reversed changes of lipoxin A4 and leukotrienes in children with asthma in different severity degree. Pediatr Pulmonol 2010;45:333–340.
8. Levy BD, Bonnans C, Silverman ES, Palmer LJ, Marigowda G, Israel E, et al. Diminished lipoxin biosynthesis in severe asthma. Am J Respir Crit Care Med 2005;172:824–830.
9. Da Dalt L, Callegaro S, Carraro S, Andreola B, Corradi M, Baraldi E. Nasal lavage leukotrienes in infants with RSV bronchiolitis. Pediatr Allergy Immunol 2007;18:100–104.
10. American Academy of Pediatrics Subcommittee on Diagnosis and Management of Bronchiolitis. Diagnosis and management of bronchiolitis. Pediatrics 2006;118:1774–1793.
11. Parkin PC, Macarthur C, Saunders NR, Diamond SA, Winders PM. Development of a clinical asthma score for use in hospitalized children between 1 and 5 years of age. J Clin Epidemiol 1996;49:821–825.
12. Bisgaard H, Flores-Nunez A, Goh A, Azimi P, Halkas A, Malice MP, et al. Study of montelukast for the treatment of respiratory symptoms of post-respiratory syncytialvirus bronchiolitis in children. Am J Respir Crit Care Med 2008;178:854–860.
13. Kim CK, Choi J, Kim HB, Callaway Z, Shin BM, Kim JT, et al. A randomized intervention of montelukast for post-bronchiolitis: effect on eosinophil degranulation. J Pediatr 2010;156:749–754.
14. Amirav I, Luder AS, Kruger N, Borovitch Y, Babai I, Miron D, et al. A double-blind, placebo-controlled, randomized trial of montelukast for acute bronchiolitis. Pediatrics 2008;122:e1249–e1255.
15. Li CZ, Rao JJ, Wang R, Sun H, Ai HW. Analysis of non-bacterial respiratory pathogen infection in children with asthmatic diseases. Chin J Contemp Pediatr 2012;14:834–837. [In Chinese]
16. Ji W, Chen ZR, Zhou WF, Sun HM, Li BQ, Cai LH, et al. Etiology of acute respiratory tract infection in hospitalized children in Suzhou from 2005 to 2011. Chin J Prev Med 2013;47:497–503. [In Chinese]
17. Jeong YC, Yeo MS, Kim JH, Lee HB, Oh JW. Mycoplasma pneumoniae Infection Affects the Serum Levels of Vascular Endothelial Growth Factor and Interleukin-5 in Atopic Children. Allergy Asthma Immunol Res 2012;4:92–97.
18. Choi IS, Byeon JH, Yoo Y, Lee KC, Choung JT. Increased serum interleukin-5 and vascular endothelial growth factor in children with acute Mycoplasma pneumonia and wheeze. Pediatr Pulmonol 2009;44:423–428.
19. Koh YY, Park Y, Lee HJ, Kim CK. Levels of interleukin-2, interferon-gamma, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production. Pediatrics 2001;107:E39.
20. Stelmach I, Podsiadlowicz-Borzecka M, Grzelewski T, Majak P, Stelmach W, Jerzynska J, et al. Humoral and cellular immunity in children with Mycoplasma pneumoniae infection: a 1-year prospective study. Clin Diagn Lab Immunol 2005;12:1246–1250.
21. Shimizu T, Mochizuki H, Kato M, Shigeta M, Morikawa A, Hori T. Immunoglobulin levels, number of eosinophils in the peripheral blood and bronchial hypersensitivity in children with Mycoplasma pneumoniae pneumonia. Arerugi 1991;40:21–27. [In Japanese]
22. Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, et al. Multi-pronged inhibition of airway hyperresponsiveness and inflammation by lipoxin A(4). Nat Med 2002;8:1018–1023.
23. Wu SH, Liao PY, Yin PL, Zhang YM, Dong L. Elevated expressions of 15-lipoxygenase and lipoxin A4 in children with acutepoststreptococcal glomerulonephritis. Am J Pathol 2009;174:115–122.
24. Guo H, Cheng HJ, Liu L. Changes of leukotrienes in children with Mycoplasma pneumoniae pneumonia. Matern Child Health J 2009;24:1221–1222. [In Chinese]
25. Zedan M, Gamil N, El-Assmy M, Fayez E, Nasef N, Fouda A, et al. Montelukast as an episodic modifier for acute viral bronchiolitis: a randomized trial. Allergy Asthma Proc 2010;31:147–153.
26. Proesmans M, Sauer K, Govaere E, Raes M, De Bilderling G, De Boeck K. Montelukast does not prevent reactive airway disease in young children hospitalized for RSV bronchiolitis. Acta Paediatr 2009;98:1830–1834.
27. Bisgaard H, Study Group on Montelukast and Respiratory Syncytial Virus. A randomized trial of montelukast in respiratory syncytial virus postbronchiolitis. Am J Respir Crit Care Med 2003;167:379–383.
28. Bisgaard H, Zielen S, Garcia-Garcia ML, Johnston SL, Gilles L, Menten J, et al. Montelukast reduces asthma exacerbations in 2-to 5-year-old children with intermittent asthma. Am J Respir Crit Care Med 2005;171:315–322.
29. Yamakawa Y, Ohtsuka Y, Ohtani K, Fujii T, Nagata S, Yamashiro Y, et al. Effects of leukotriene receptor antagonists on peripheral eosinophil counts and serum IgE levels in children with food allergy. Drugs R D 2010;10:147–154.
30. Stelmach I, Grzelewski T, Majak P, Majak J, Bobrowska M, Jerzynska J, et al. The effect of triamcinolone, montelukast and formoterol on serum levels of IL-4, IgE and clinical parameters in children with asthma. Pol Merkur Lekarski 2001;11:247–251. [In Polish]
31. Spinozzi F, Russano AM, Piattoni S, Agea E, Bistoni O, de Benedictis D, et al. Biological effects of montelukast, a cysteinyl-leukotriene receptor-antagonist, on T lymphocytes. Clin Exp Allergy 2004;34:1876–1882.
32. Baek HS, Cho J, Kim JH, Oh JW, Lee HB. Ratio of leukotriene e(4) to exhaled nitric oxide and the therapeutic response in children with exercise-induced bronchoconstriction. Allergy Asthma Immunol Res 2013;5:26–33.