Pulmonary hyperpolarized 129Xe morphometry for mapping xenon gas concentrations and alveolar oxygen partial pressure: Proof-of-concept demonstration in healthy and COPD subjects

Magnetic Resonance in Medicine

Volumn 74, Issue 6, 2015, Pages 1726-1732

  Ouriadov, A ^a   Farag, A ^a   Kirby, M ^b,c   McCormack, D G ^b   Parraga, G ^a,b   Santyr, G E ^a,b,d  

^a ROBARTS RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

diffusion; hyperpolarized; lung, morphometry; pAO2; xenon concentration

Indexed keywords

BIOLOGICAL ORGANS; DIFFUSION; MAGNETIC RESONANCE IMAGING; OXYGEN; PARTIAL PRESSURE; PHANTOMS; PULMONARY DISEASES; XENON;

FUNCTIONAL RESIDUAL CAPACITIES; HYPERPOLARIZED; MORPHOMETRIC PARAMETERS; MORPHOMETRY; OXYGEN PARTIAL PRESSURE; PAO2; PHANTOM MEASUREMENTS; REGIONAL DIFFERENCES;

SMOKE;

OXYGEN; UNCLASSIFIED DRUG; XENON; XENON 129; CONTRAST MEDIUM; RADIOPHARMACEUTICAL AGENT;

ADULT; AGED; ARTICLE; CASE REPORT; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONCENTRATION (PARAMETERS); DIFFUSION COEFFICIENT; DIFFUSION WEIGHTED IMAGING; FUNCTIONAL RESIDUAL CAPACITY; HUMAN; HYPERPOLARIZATION; IN VIVO STUDY; LUNG ALVEOLUS OXYGEN TENSION; MIDDLE AGED; MORPHOMETRICS; PHANTOM; SMOKING; COMPUTER ASSISTED DIAGNOSIS; FEMALE; LUNG ALVEOLUS; MALE; METABOLISM; MOLECULAR IMAGING; PATHOLOGY; PROCEDURES; REPRODUCIBILITY; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; CONTRAST MEDIA; DIFFUSION MAGNETIC RESONANCE IMAGING; FEMALE; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MALE; MIDDLE AGED; MOLECULAR IMAGING; OXYGEN; PULMONARY ALVEOLI; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TISSUE DISTRIBUTION; XENON; XENON ISOTOPES;

EID: 84955171059     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.25550     Document Type: Article

References (22)

1. Albert MS, Cates GD, Driehuys B, Happer W, Saam B, Springer CS Jr, Wishnia A,. Biological magnetic resonance imaging using laser-polarized 129Xe. Nature 1994; 370: 199-201.
2. Kaushik SS, Cleveland ZI, Cofer GP, et al., Diffusion weighted hyperpolarized (129)Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease. Magn Reson Med 2011; 65: 1155-1165.
3. Kirby M, Svenningsen S, Owrangi A, et al., Hyperpolarized helium-3 and xenon-129 magnetic resonance imaging in healthy volunteers and subjects with chronic obstructive pulmonary disease. Radiology 2012; 265: 600-610.
4. Sukstanskii AL, Yablonskiy DA,. Lung morphometry with hyperpolarized 129Xe: theoretical background. Magn Reson Med 2012; 67: 856-866.
5. Yablonskiy DA, Sukstanskii AL, Quirk JD, Woods JC, Conradi MS,. Probing lung microstructure with hyperpolarized noble gas diffusion MRI: theoretical models and experimental results. Magn Reson Med 2014; 71: 486-505.
6. Ouriadov A, Farag A, Kirby M, McCormack DG, Parraga G, Santyr GE,. Lung morphometry using hyperpolarized 129Xe apparent diffusion coefficient anisotropy in chronic obstructive pulmonary disease. Magn Reson Med 2013; 70: 1699-1706.
7. Hamedani H, Kadlececk S, Han B, Emami K, Xin Y, Ishii M, Rossman M, Rizi R,. A multiple-breath 3He wash-in regimen to reduce the limitation of 3He pAO2-imaging due to delayed ventilation and slow filling. In Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, Utah, USA, 2013. Abstract 0821.
8. Miller GW, Altes TA, Brookeman JR, de Lange EE, Mugler JP III,. Hyperpolarized 3He lung ventilation imaging with B1-inhomogeneity correction in a single breath-hold scan. MAGMA 2004; 16: 218-226.
9. Ouriadov A, Etemad-Rezai R, Parraga G, Santyr GE,. Correction of errors due to RF field inhomogeneities in hyperpolarized 3He measurement of alveolar oxygen partial pressure in human lung. In Proceedings of the 16th Annual Meeting of ISMRM, Toronto, Canada, 2008. Abstract 3786.
10. Marshall H, Parra-Robles J, Deppe MH, Lipson DA, Lawson R, Wild JM,. 3He pO2 mapping is limited by delayed-ventilation and diffusion in chronic obstructive pulmonary disease. Magn Reson Med 2014; 71: 1172-1178.
11. Hamedani H, Kadlececk S, Han B, Emami K, Xin Y, Ishii M, Rossman M, Rizi R,. A simultaneous multi-breath scheme for measurement of ADC, pAO2 and fractional ventilation using 3He MRI in human. In Proceedings of the 22nd Annual Meeting of ISMRM, Milano, Italy, 2014. Abstract 1468.
12. Miller MR, Hankinson J, Brusasco V, et al., Standardisation of spirometry. Eur Respir J 2005; 26: 319-338.
13. Farag A, Wang J, Ouriadov A, Parraga G, Santyr G,. Unshielded and asymmetric RF transmit coil for hyperpolarized 129Xe human lung imaging at 3.0T. In Proceedings of the 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012. Abstract 1233.
14. Hersman FW, Ruset IC, Ketel S, et al., Large production system for hyperpolarized 129Xe for human lung imaging studies. Acad Radiol 2008; 15: 683-692.
15. Chen XJ, Moller HE, Chawla MS, Cofer GP, Driehuys B, Hedlund LW, Johnson GA,. Spatially resolved measurements of hyperpolarized gas properties in the lung in vivo. Part I: diffusion coefficient. Magn Reson Med 1999; 42: 721-728.
16. Yablonskiy DA, Sukstanskii AL, Leeawoods JC, Gierada DS, Bretthorst GL, Lefrak SS, Cooper JD, Conradi MS,. Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion. Proc Natl Acad Sci U S A 2002; 99: 3111-3116.
17. Quirk JD, Lutey BA, Gierada DS, Woods JC, Senior RM, Lefrak SS, Sukstanskii AL, Conradi MS, Yablonskiy DA,. In vivo detection of acinar microstructural changes in early emphysema with 3He lung morphometry. Radiology 2011; 260: 866-874.
18. Möller HE, Chen XJ, Saam B, Hagspiel KD, Johnson GA, Altes TA, de Lange EE, Kauczor HU,. MRI of the lungs using hyperpolarized noble gases. Magn Reson Med 2002; 47: 1029-1051.
19. Ouriadov A, Kirby M, Farag A, McCormack DG, Parraga G, Santyr GE,. Hyperpolarized 129Xe magnetic resonance imaging lung morphometry method for estimation of xenon concentration gradients in chronic obstructive pulmonary disease. In Proceedings of the 21st Annual Meeting of ISMRM, Salt Lake City, Utah, USA, 2013. Abstract 1457.
20. Mugler JP, Altes TA,. Hyperpolarized 129Xe MRI of the human lung. J Magn Reson Imaging 2013; 37: 313-331.
21. Nikolaou P, Coffey AM, Walkup LL, et al., Near-unity nuclear polarization with an open-source 129Xe hyperpolarizer for NMR and MRI. Proc Natl Acad Sci U S A 2013; 110: 14150-14155.
22. Lee RF, Johnson G, Stefanescu C, Trampel R, McGuinness G, Stoeckel B,. A 24-ch phased-array system for hyperpolarized helium gas parallel MRI to evaluate lung functions. In Proceedings of the IEEE-EMBS 27th Annual International Conference, Shanghai, Chine, 2005. Abstract 4278.