Replacing the promoter of the murine gene encoding P-selectin with the human promoter confers human-like basal and inducible expression in mice

Journal of Biological Chemistry

Volumn 291, Issue 3, 2016, Pages 1441-1447

  Liu, Zhenghui ^a   Zhang, Nan ^b   Shao, Bojing ^a   Panicker, Sumith R ^a   Fu, Jianxin ^a   McEver, Rodger P ^a,b  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; ENDOTHELIAL CELLS; GENE ENCODING; GENE EXPRESSION; GENES; PATHOLOGY;

BASAL EXPRESSION; CONTACT HYPERSENSITIVITY; HUMAN PROMOTERS; INDUCIBLE EXPRESSION; INTERLEUKIN-1; ROLLING VELOCITY; TRANSGENIC MICE; UP-REGULATION;

MAMMALS;

LIPOPOLYSACCHARIDE; MESSENGER RNA; PADGEM PROTEIN; TUMOR NECROSIS FACTOR ALPHA; SELP PROTEIN, HUMAN; TUMOR NECROSIS FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; EMBRYO; EXON; GENE EXPRESSION REGULATION; GENE TARGETING; IN VIVO STUDY; INFLAMMATION; INTRON; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SELP GENE; THROMBOCYTE; UPREGULATION; VENULE; WILD TYPE; ANIMAL; ANTIBODY SPECIFICITY; C57BL MOUSE; CHEMISTRY; CONTACT DERMATITIS; CROSS BREEDING; DRUG EFFECTS; GENETICS; GERMFREE ANIMAL; HUMAN; IMMUNOLOGY; LEUKOCYTE ROLLING; METABOLISM; NUCLEOTIDE SEQUENCE; SPECIES DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; CROSSES, GENETIC; DERMATITIS, CONTACT; GENE EXPRESSION REGULATION; HUMANS; LEUKOCYTE ROLLING; LIPOPOLYSACCHARIDES; MICE, INBRED C57BL; MICE, TRANSGENIC; ORGAN SPECIFICITY; P-SELECTIN; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SPECIES SPECIFICITY; SPECIFIC PATHOGEN-FREE ORGANISMS; TUMOR NECROSIS FACTOR-ALPHA; VENULES;

EID: 84954502361     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.702126     Document Type: Article

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