Longitudinal micro-CT provides biomarkers of lung disease that can be used to assess the effect of therapy in preclinical mouse models, and reveal compensatory changes in lung volume

DMM Disease Models and Mechanisms

Volumn 9, Issue 1, 2016, Pages 91-98

  Velde, Greetje Vande ^a   Poelmans, Jennifer ^a   De Langhe, Ellen ^b,c   Hillen, Amy ^a   Vanoirbeek, Jeroen ^d   Himmelreich, Uwe ^a   Lories, Rik J ^b,c  

^a DEPARTMENT OF IMAGING AND PATHOLOGY   (Belgium)

^b SKELETAL BIOLOGY AND ENGINEERING RESEARCH CENTER   (Belgium)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Aspergillosis; Biomarkers; Bleomycin; Cryptococcosis; Disease models; In vivo; Infectious diseases; Lung inflammation; Lung volume; Micro computed tomography; Pulmonary fibrosis; Quantification

Indexed keywords

IMATINIB; BIOLOGICAL MARKER; BLEOMYCIN;

AERATED LUNG VOLUME; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTED TOMOGRAPHY SCANNER; CONTROLLED STUDY; DISEASE COURSE; HISTOLOGY; LUNG ASPERGILLOSIS; LUNG DENSITY; LUNG DISEASE; LUNG FIBROSIS; LUNG INFECTION; LUNG TISSUE VOLUME; MALE; MICRO-COMPUTED TOMOGRAPHY; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PULMONARY CRYPTOCOCCOSIS; RESPIRATORY TRACT PARAMETERS; TOTAL LUNG CAPACITY; ANIMAL; BAGG ALBINO MOUSE; C57BL MOUSE; CHEMICALLY INDUCED; CRYPTOCOCCOSIS; DIAGNOSTIC IMAGING; DISEASE MODEL; FIBROSIS; INFLAMMATION; LUNG; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; BIOMARKERS; BLEOMYCIN; CRYPTOCOCCOSIS; DISEASE MODELS, ANIMAL; FIBROSIS; IMATINIB MESYLATE; INFLAMMATION; LUNG; LUNG DISEASES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PULMONARY ASPERGILLOSIS; X-RAY MICROTOMOGRAPHY;

EID: 84954478201     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.020321     Document Type: Article

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