Curiouser and curiouser: The macrocyclic lactone, abamectin, is also a potent inhibitor of pyrantel/tribendimidine nicotinic acetylcholine receptors of gastro-intestinal worms

PLoS ONE

Volumn 11, Issue 1, 2016, Pages

  Abongwa, Melanie ^a   Buxton, Samuel K ^a   Robertson, Alan P ^a   Martin, Richard J ^a  

^a IOWA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ABAMECTIN; ACETYLCHOLINE; CHLORIDE CHANNEL; DERQUANTEL; GLUTAMATE GATED CHLORIDE CHANNEL; NICOTINIC RECEPTOR; PYRANTEL; UNCLASSIFIED DRUG; ANTHELMINTIC AGENT; INDOLE DERIVATIVE; IVERMECTIN; NICOTINIC RECEPTOR BLOCKING AGENT; OXEPINE DERIVATIVE; PHENYLENEDIAMINE DERIVATIVE; TRIBENDIMIDINE;

ANIMAL CELL; ANTHELMINTIC ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPETITIVE INHIBITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG STRUCTURE; FEMALE; NEMATODE; NONHUMAN; OESOPHAGOSTOMUM; OOCYTE; PROTEIN EXPRESSION; RECEPTOR BLOCKING; VOLTAGE CLAMP TECHNIQUE; XENOPUS; ALLOSTERIC SITE; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HAEMONCHUS; HELMINTHIASIS; INTESTINAL DISEASES, PARASITIC; METABOLISM; MOLECULAR CLONING; PARASITOLOGY; PATCH CLAMP TECHNIQUE; XENOPUS LAEVIS;

ACETYLCHOLINE; ALLOSTERIC SITE; ANIMALS; ANTHELMINTICS; CLONING, MOLECULAR; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HAEMONCHUS; HELMINTHIASIS; INDOLES; INTESTINAL DISEASES, PARASITIC; IVERMECTIN; NEMATODA; NICOTINIC ANTAGONISTS; OOCYTES; OXEPINS; PATCH-CLAMP TECHNIQUES; PHENYLENEDIAMINES; PYRANTEL; RECEPTORS, NICOTINIC; XENOPUS LAEVIS;

EID: 84954473106     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0146854     Document Type: Article

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