Anaemia in patients with HIV-associated TB: Relative contributions of anaemia of chronic disease and iron deficiency

International Journal of Tuberculosis and Lung Disease

Volumn 20, Issue 2, 2016, Pages 193-201

  Kerkhoff, A D ^a,b,c   Meintjes, G ^d,e,f   Opie, J ^d,g   Vogt, M ^c   Jhilmeet, N ^e   Wood, R ^c   Lawn, S D ^c,h  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c Institute of Infectious Disease and Molecular Medicine   (South Africa)

^d UNIVERSITY OF CAPE TOWN   (South Africa)

^e UNIVERSITY OF CAPE TOWN   (South Africa)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

^g NATIONAL HEALTH LABORATORY SERVICE   (South Africa)

^h LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Africa; AIDS; Anaemia; Hepci din; Human immunodeficiency virus; Iron; Mechanism; Tuberculosis

Indexed keywords

HEMOGLOBIN; HEPCIDIN; ANTIANEMIC AGENT; BIOLOGICAL MARKER;

ADULT; AGE DISTRIBUTION; ANEMIA; ARTICLE; CAUSAL ATTRIBUTION; DIET SUPPLEMENTATION; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; HEMOGLOBIN BLOOD LEVEL; HIV ASSOCIATED TUBERCULOSIS; HORMONE BLOOD LEVEL; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PRIORITY JOURNAL; SEX DIFFERENCE; TUBERCULOSIS; AMBULATORY CARE; ANEMIA, IRON-DEFICIENCY; BLOOD; HIV INFECTIONS; HOSPITALIZATION; PREVALENCE; PROSPECTIVE STUDY; RISK FACTOR; SEVERITY OF ILLNESS INDEX; SOUTH AFRICA;

ADULT; AMBULATORY CARE; ANEMIA, IRON-DEFICIENCY; BIOMARKERS; COINFECTION; FEMALE; HEMATINICS; HIV INFECTIONS; HOSPITALIZATION; HUMANS; MALE; PREVALENCE; PROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SOUTH AFRICA; TUBERCULOSIS;

EID: 84954414065     PISSN: 10273719     EISSN: 18157920     Source Type: Journal    
DOI: 10.5588/ijtld.15.0558     Document Type: Article

References (34)

1. Kassebaum N.J., Jasrasaria R, Naghavi M., et al. A systematic analysis of global anemia burden from 1990 to 2010. Blood 2014; 123: 615-624.
2. Kerkhoff A.D., Wood R, Vogt M., Lawn S D. Predictive value of anemia for tuberculosis in HIV-infected patients in sub-Saharan Africa: An indication for routine microbiological investigation using new rapid assays. J Acquir Immune Defic Syndr 2014; 66: 33-40.
3. Kerkhoff A.D., Wood R, Cobelens F G, Gupta-Wright A, Bekker L-G, Lawn S D. The predictive value of current haemoglobin levels for incident tuberculosis and/or mortality during longterm antiretroviral therapy in South Africa: a cohort study. BMC Med 2015; 13: 70.
4. Minchella P.A., Donkor S, Owolabi O., Sutherland J S, McDermid J M. Complex anemia in tuberculosis: the need to consider causes and timing when designing interventions. Clin Infect Dis 2015; 60: 764-772.
5. Lee S.W., Kang Y A, Yoon Y S, et al. The prevalence and evolution of anemia associated with tuberculosis. J Korean Med Sci 2006; 21: 1028-1032.
6. Volberding P.A., Levine A M, Dieterich D, et al Anemia in HIV infection: clinical impact and evidence-based management strategies. Clin Infect Dis 2004; 38: 1454-1463.
7. Volberding P. The impact of anemia on quality of life in human immunodeficiency virus-infected patients. J Infect Dis 2002; 185 (Suppl 2): S110-S114.
8. th Union World Conference on Lung Health, Barcelona, Spain, 28 October-1 November 2014. Oral abstract OPA-209-30.
9. Sullivan P. Associations of anemia, treatments for anemia, and survival in patients with human immunodeficiency virus infection. J Infect Dis 2002; 185 (Suppl 2): S138-S142.
10. van Lettow M., West C E, van der Meer J W M, Wieringa F T, Semba R D. Low plasma selenium concentrations, high plasma human immunodeficiency virus load and high interleukin-6 concentrations are risk factors associated with anemia in adults presenting with pulmonary tuberculosis in Zomba district, Malawi. Eur J Clin Nutr 2005; 59: 526-532.
11. Kerkhoff A.D., Meintjes G, Burton R., Vogt M, Wood R, Lawn S D. Relationship between blood concentration of hepcidin and anemia severity, mycobacterial burden and mortality in patients with HIV-associated tuberculosis. J Infect Dis 2015; pii: jiv364.
12. Calis J C J, Phiri K S, Faragher E B, et al. Severe anemia in Malawian children. N Engl J Med 2008; 358: 888-899.
13. Weiss G, Goodnough L T. Anemia of chronic disease. N Engl J Med 2005; 352: 1011-1023.
14. World Health Organization. Iron deficiency anaemia: assessment, prevention and control: a guide for programme managers. WHO/NHD/01.3. Geneva, Switzerland: WHO, 2001. http://apps.who.int/iris/bitstream/10665/66914/1/WHO-NHD-01.3.pdf?ua=1 Accessed October 2015.
15. Koulaouzidis A, Said E, Cottier R., Saeed A A. Soluble transferrin receptors and iron deficiency, a step beyond ferritin. A systematic review. J Gastrointestin Liver Dis 2009; 18: 345-352.
16. Phiri K.S., Calis J C J Siyasiya A, Bates I, Brabin B, van Hensbroek M B. New cut-off values for ferritin and soluble transferrin receptor for the assessment of iron deficiency in children in a high infection pressure area. J Clin Path 2009; 62: 1103-1106.
17. Bregman D.B., Morris D, Koch T A, He A, Goodnough L T. Hepcidin levels predict nonresponsiveness to oral iron therapy in patients with iron deficiency anemia. Am J Hematol 2013; 88: 97-101.
18. Lawn S.D., Kerkhoff A D, Vogt M, Wood R. Diagnostic accuracy of a low-cost, urine antigen, point-of-care screening assay for HIV-associated pulmonary tuberculosis before antiretroviral therapy: a descriptive study. Lancet Infect Dis 2012; 12: 201-209.
19. Lawn S.D., Kerkhoff A D, Burton R, et al Rapid effective microbiological screening for tuberculosis in HIV-positive patients on the first day of acute hospital admission in South Africa by systematic Xpert MTB/RIF testing urine samples: a prospective cohort. BMC Med 2015; 13: 192.
20. Gupta A, Wood R, Kaplan R., Bekker L-G, Lawn S D. Tuberculosis incidence rates during 8 years of follow-up of an antiretroviral treatment cohort in South Africa: comparison with rates in the community. PLOS ONE 2012; 7: e34156.
21. World Health Organization. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity. WHO/NMH/ NHD/MNM/11.1. Geneva, Switzerland: WHO, 2011. http:// apps.who.int/iris/bitstream/10665/85839/3/WHO-NMH-NHD-MNM-11.1-eng.pdf?ua=1. Accessed October 2015.
22. Cullis J.O. Diagnosis and management of anaemia of chronic disease: current status. Br J Haematol 2011; 154: 289-300.
23. Levey A.S., Coresh J, Greene T., et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med 2006; 145: 247-254.
24. Armitage A.E., Eddowes L A, Gileadi U, et al Hepcidin regulation by innate immune and infectious stimuli. Blood 2011; 118: 4129-4139.
25. Ganz T, Nemeth E. The hepcidin-ferroportin system as a therapeutic target in anemias and iron overload disorders. Hematology Am Soc Hematol Educ Program 2011; 2011: 538-542.
26. Lawn S.D., Obeng J, Acheampong J W, Griffin G E. Resolution of the acute-phase response in West African patients receiving treatment for pulmonary tuberculosis. Int J Tuberc Lung Dis 2000; 4: 340-344.
27. Kerkhoff A.D., Wood R, Cobelens F G, Gupta-Wright A, Bekker L-G, Lawn S D. Resolution of anaemia in a cohort of HIV-infected patients with a high prevalence and incidence of tuberculosis receiving antiretroviral therapy in South Africa. BMC Infect Dis 2014; 14: 702.
28. Kerkhoff A.D., Lawn S D. Iron replacement therapy and anemia associated with chronic infectious diseases in sub-Saharan Africa. Clin Infect Dis 2015; 60: 1438-1439.
29. Tolkien Z, Stecher L, Mander A P, Pereira D I A Powell J J. Ferrous sulfate supplementation causes significant gastrointestinal side-effects in adults: a systematic review and meta-analysis. PLOS ONE 2015; 10: e0117383.
30. Gangaidzo I.T., Moyo V M, Mvundura E, et al Association of pulmonary tuberculosis with increased dietary iron. J Infect Dis 2001; 184: 936-939.
31. Gordeuk V.R., Delanghe J R, Langlois M R, Boelaert J R. Iron status and the outcome of HIV infection: an overview. J Clin Virol 2001; 20: 111-115.
32. Boelaert J.R., Vandecasteele S J, Appelberg R, Gordeuk V R. The effect of the host's iron status on tuberculosis. J Infect Dis 2007; 195: 1745-1753.
33. McDermid J.M., Jaye A, Schim van der Loeff M F, et al. Elevated iron status strongly predicts mortality in West African adults with HIV infection. J Acquir Immune Defic Syndr 2007; 46: 498-507.
34. Johannessen A, Naman E, Gundersen S G, Bruun J N. Antiretroviral treatment reverses HIV-associated anemia in rural Tanzania. BMC Infect Dis 2011; 11: 190.