Using an Alzheimer disease polygenic risk score to predict memory decline in black and white Americans over 14 years of follow-up

Alzheimer Disease and Associated Disorders

Volumn 30, Issue 3, 2016, Pages 195-202

  Marden, Jessica R ^a   Mayeda, Elizabeth R ^a   Walter, Stefan ^a   Vivot, Alexandre ^a   Tchetgen, Eric J Tchetgen ^b,c   Kawachi, Ichiro ^a   Glymour, M Maria ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

Author keywords

Cognition; Decline; Dementia; Genetics; Memory; Race

Indexed keywords

APOLIPOPROTEIN E;

ADULT; AFRICAN AMERICAN; ALZHEIMER DISEASE; ALZHEIMER DISEASE POLYGENIC RISK SCORE; APOLIPOPROTEIN E GENE; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; EUROPEAN AMERICAN; FEMALE; FOLLOW UP; GENE; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY; MEMORY ASSESSMENT; MIDDLE AGED; PRIORITY JOURNAL; SCORING SYSTEM; SINGLE NUCLEOTIDE POLYMORPHISM; CAUCASIAN; ETHNIC GROUP; GENETICS; GENOME-WIDE ASSOCIATION STUDY; MEMORY DISORDER; PROCEDURES; RISK FACTOR; UNITED STATES;

AFRICAN AMERICANS; ALZHEIMER DISEASE; ETHNIC GROUPS; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; FOLLOW-UP STUDIES; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MEMORY DISORDERS; MIDDLE AGED; RISK FACTORS; UNITED STATES;

EID: 84954348942     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/WAD.0000000000000137     Document Type: Article

References (40)

1. Lambert J-C, Ibrahim-Verbaas CA, Harold D, et al. Metaanalysis of 74, 046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nat Genet. 2013;45:1452-1458.
2. Naj AC, Jun. G, Beecham GW, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-441.
3. Hollingworth P, Harold D, Sims R, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011;43:429-435.
4. Reitz C, Jun. G, Naj A, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4, and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013;309:1483-1492.
5. Seshadri S, Fitzpatrick AL, Ikram MA, et al. Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA. 2010;303:1832-1840.
6. Stern Y. Cognitive reserve in ageing and Alzheimer's disease. Lancet Neurol. 2012;11:1006-1012.
7. Bertram L, McQueen M, Mullin K, et al. Systematic metaanalyses of Alzheimer disease genetic association studies: the AlzGene database. Nature genetics. 2007;39:17-23.
8. Marden JR, Walter S, Tchetgen Tchetgen EJ, et al. Validation of a polygenic risk score for dementia in black and white individuals. Brain Behav. 2014;4:687-697.
9. Verhaaren BF, Vernooij MW, Koudstaal PJ, et al. Alzheimer's disease genes and cognition in the nondemented general population. Biol Psychiatry. 2013;73:429-434.
10. Barral S, Bird T, Goate A, et al. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 2012;78:1464-1471.
11. Harris SE, Davies G, Luciano M, et al. Polygenic risk for Alzheimer's disease is not associated with cognitive ability or cognitive aging in non-demented older people. J Alzheimers Dis. 2014;39:565-574.
12. Plassman BL, Williams JW, Burke JR, et al. Systematic review: factors associated with risk for and possible prevention of cognitive decline in later life. Ann Intern Med. 2010;153:182-193.
13. Logue MW, Schu M, Vardarajan BN, et al. A comprehensive genetic association study of Alzheimer disease in African Americans. Arch Neurol. 2011;68:1569-1579.
14. Pedraza O, Allen M, Jennette K, et al. Evaluation of memory endophenotypes for association with CLU, CR1, and PIC-ALM variants in black and white subjects. Alzheimers Dement. 2014;10:205-213.
15. Pfaff C, Parra E, Bonilla C, et al. Population structure in admixed populations: effect of admixture dynamics on the pattern of linkage disequilibrium. Am J Hum Genet. 2001;68:198-207.
16. Tishkoff SA, Williams SM. Genetic analysis of African populations: human evolution and complex disease. Nat Rev Genet. 2002;3:611-621.
17. McClellan J, King M-C. Genetic heterogeneity in human disease. Cell. 2010;141:210-217.
18. Burchard EG, Ziv E, Coyle N, et al. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348:1170-1175.
19. Yaffe K, Lindquist K, Vittinghoff E, et al. The effect of maintaining cognition on risk of disability and death. J Am Geriatr Soc. 2010;58:889-894.
20. Lavery LL, Dodge HH, Snitz B, et al. Cognitive decline and mortality in a community-based cohort: the Monongahela Valley Independent Elders Survey. J Am Geriatr Soc. 2009;57:94-100.
21. Beydoun MA, Beydoun HA, Kaufman JS, et al. Apolipoprotein E epsilon4 allele interacts with sex and cognitive status to influence all-cause and cause-specific mortality in US older adults. J Am Geriatr Soc. 2013;61:525-534.
22. Rosvall L, Rizzuto D, Wang HX, et al. APOE-related mortality: effect of dementia, cardiovascular disease and gender. Neurobiol Aging. 2009;30:1545-1551.
23. Hauser RM, Willis RJ. Survey design and methodology in the Health and Retirement Study and the Wisconsin Longitudinal Study. Popul Dev Rev. 2004;30:209-235.
24. Juster FT, Suzman R. An overview of the Health and Retirement Study. J Hum Resour. 1995;30:S7-S56.
25. Heeringa SG, Connor J. Technical Description of the Health and Retirement Study Sample Design. Ann Arbor, MI: Survey Research Center, University of Michigan; 1995. DR-002.
26. Ofstedal MB, Fisher GF, Herzog AR. Documentation of cognitive functioning measures in the Health and Retirement Study. HRS Documentation Report, 2005. DR-006. Available at: http://hrsonline.isr.umich.edu/sitedocs/userg/dr-006.pdf. Accessed November, 2015.
27. Wu Q, Tchetgen ET, Osypuk T, et al. Combining direct and proxy assessments to reduce attrition bias in a longitudinal study. Alzheimer Dis Assoc Disord. 2012;27:207-212.
28. Zheng X, Levine D, Shen J, et al. A high-performance computing toolset for relatedness and principal component analysis of SNP data. Bioinformatics. 2012;28:3326-3328.
29. Health and Retirement Study. Genome Wide Association Study Overview. 2010.
30. Bekris LM, Yu CE, Bird TD, et al. Review article: genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 2010;23:213-227.
31. Bertram L, McQueen MB, Mullin K, et al. Systematic metaanalyses of Alzheimer disease genetic association studies: the AlzGene database. Nat Genet. 2007;39:17-23.
32. Weir D, Faul JD, Kardia SL, et al. Quality Control Report for Genotypic Data. Seattle, WA: Univ. of Washington; 2012.
33. Sweet RA, Seltman H, Emanuel JE, et al. Effect of Alzheimer's disease risk genes on trajectories of cognitive function in the Cardiovascular Health Study. Am J Psychiatry. 2012;169:954-962.
34. Chibnik LB, Shulman JM, Leurgans SE, et al. CR1 is associated with amyloid plaque burden and age-related cognitive decline. Ann Neurol. 2011;69:560-569.
35. Keenan BT, Shulman JM, Chibnik LB, et al. A coding variant in CR1 interacts with APOE-epsilon4 to influence cognitive decline. Hum Mol Genet. 2012;21:2377-2388.
36. Thambisetty M, Beason-Held LL, An Y, et al. Alzheimer risk variant CLU and brain function during aging. Biol Psychiatry. 2013;73:399-405.
37. Mengel-From J, Thinggaard M, Lindahl-Jacobsen R, et al. CLU genetic variants and cognitive decline among elderly and oldest old. PloS One. 2013;8:e79105.
38. Harris SE, Deary IJ. The genetics of cognitive ability and cognitive ageing in healthy older people. Trends Cogn Sci. 2011;15:388-394.
39. Barnes L, Arvanitakis Z, Yu L, et al. Apolipoprotein E and change in episodic memory in blacks and whites. Neuroepidemiology. 2013;40:211-219.
40. Manly JJ, Jacobs DM, Sano M, et al. Cognitive test performance among nondemented elderly African Americans and whites. Neurology. 1998;50:1238-1245.