High cut-off dialysis in chronic haemodialysis patients

European Journal of Clinical Investigation

Volumn 45, Issue 12, 2015, Pages 1333-1340

  Girndt, Matthias ^a   Fiedler, Roman ^a   Martus, Peter ^b   Pawlak, Michael ^c   Storr, Markus ^d   Bohler, Torsten ^d   Glomb, Marcus A ^a   Liehr, Kristin ^a   Henning, Christian ^a   Templin, Markus ^c   Trojanowicz, Bogusz ^a   Ulrich, Christof ^a   Werner, Kristin ^d   Zickler, Daniel ^e   Schindler, Ralf ^e  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c NMI Technologietransfer GmbH   (Germany)

^d Gambro Dialysatoren GmbH   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Haemodialysis; High cut off membrane; Inflammation; Monocytes; Multiplex immunoassay

Indexed keywords

ALBUMIN; CD16 ANTIGEN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; P SELECTIN GLYCOPROTEIN LIGAND 1; PHOSPHATE; PROTEIN P40; SERUM ALBUMIN; TRANSFERRIN RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR 1; UREA; BIOLOGICAL MARKER;

ADULT; AGED; ARTICLE; ARTIFICIAL KIDNEY; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIALYSIS MEMBRANE; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEMODIALYSIS; HEMODIALYSIS PATIENT; HIGH CUT OFF DIALYSIS MEMBRANE; HOSPITALIZATION; HUMAN; INFLAMMATION; LEUKOCYTE; LEUKOCYTE ACTIVATION; MALE; MOLECULAR WEIGHT; MONOCYTE; OPEN STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; UPREGULATION; ADOLESCENT; CLINICAL TRIAL; KIDNEY FAILURE, CHRONIC; METABOLISM; MIDDLE AGED; MULTICENTER STUDY; MUSCLE CELL; PATIENT SAFETY; PROCEDURES; TREATMENT OUTCOME; VERY ELDERLY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BIOMARKERS; CROSS-OVER STUDIES; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; MUSCLE CELLS; PATIENT SAFETY; PROSPECTIVE STUDIES; RENAL DIALYSIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84954307861     PISSN: 00142972     EISSN: 13652362     Source Type: Journal    
DOI: 10.1111/eci.12559     Document Type: Article

References (24)

1. Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, Griffith JL et al. Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: a pooled analysis of community-based studies. J Am Soc Nephrol 2004;15:1307-15.
2. Zimmermann J, Herrlinger S, Pruy A, Metzger T, Wanner C. Inflammation enhances cardiovascular risk and mortality in hemodialysis patients. Kidney Int 1999;55:648-58.
3. Heine GH, Ulrich C, Seibert E, Seiler S, Marell J, Reichart B et al. CD14(++)CD16(+) monocytes but not total monocyte numbers predict cardiovascular events in dialysis patients. Kidney Int 2008;73:622-9.
4. Vanholder R, Massy Z, Argiles A, Spasovski G, Verbeke F, Lameire N. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant 2005;20:1048-56.
5. Kudo S, Goto H. Intrarenal handling of recombinant human interleukin-1alpha in rats: mechanism for proximal tubular protein reabsorption. J Interferon Cytokine Res 1999;19:1161-8.
6. Boschetti-de-Fierro A, Voigt M, Storr M, Krause B. Extended characterization of a new class of membranes for blood purification: the high cut-off membranes. Int J Artif Organs 2013;36:455-63.
7. Hutchison CA, Bradwell AR, Cook M, Basnayake K, Basu S, Harding S et al. Treatment of acute renal failure secondary to multiple myeloma with chemotherapy and extended high cut-off hemodialysis. Clin J Am Soc Nephrol 2009;4:745-54.
8. Fiedler R, Neugebauer F, Ulrich C, Wienke A, Gromann C, Storr M et al. Randomized controlled pilot study of 2 weeks' treatment with high cutoff membrane for hemodialysis patients with elevated C-reactive protein. Artif Organs 2012;36:886-93.
9. Schwartz D. Méthodes statistiques à l'usage des médecins et des biologistes, 4th edn. Paris: Flammarion Medecine-Science; 1996.
10. Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO. Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med Eng Phys 2008;30:976-83.
11. Leypoldt JK, Cheung AK, Deeter RB. Single compartment models for evaluating beta 2-microglobulin clearance during hemodialysis. ASAIO J 1997;43:904-9.
12. Daugirdas JT. Simplified equations for monitoring Kt/V, PCRn, eKt/V, and ePCRn. Adv Ren Replace Ther 1995;2:295-304.
13. Zickler D, Epple C, Lun A, Storr M, Beck W, Hampel DJ et al. Randomized controlled trial with high-cutoff-membranes in chronic hemodialysis patients: humoral and cellular markers of inflammation. J Am Soc Nephrol 2009;20:90A Ref Type: Abstract.
14. Owen WF, Lew NL, Liu Y, Lowrie EG, Lazarus JM. The urea reduction ratio and serum albumin concentrations as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 1993;329:1001-6.
15. Ulrich C, Heine GH, Seibert E, Fliser D, Girndt M. Circulating monocyte subpopulations with high expression of angiotensin-converting enzyme predict mortality in patients with end-stage renal disease. Nephrol Dial Transplant 2010;25:2265-72.
16. Ulrich C, Seibert E, Heine GH, Fliser D, Girndt M. Monocyte angiotensin converting enzyme expression may be associated with atherosclerosis rather than arteriosclerosis in hemodialysis patients. Clin J Am Soc Nephrol 2011;6:505-11.
17. Hutchison CA, Cockwell P, Reid S, Chandler K, Mead GP, Harrison J et al. Efficient removal of immunoglobulin free light chains by hemodialysis for multiple myeloma: in vitro and in vivo studies. J Am Soc Nephrol 2007;18:886-95.
18. Haase M, Bellomo R, Baldwin I, Haase-Fielitz A, Fealy N, Davenport P et al. Hemodialysis membrane with a high-molecular-weight cutoff and cytokine levels in sepsis complicated by acute renal failure: a phase 1 randomized trial. Am J Kidney Dis 2007;50:296-304.
19. Morgera S, Slowinski T, Melzer C, Sobottke V, Vargas-Hein O, Volk T et al. Renal replacement therapy with high-cutoff hemofilters: impact of convection and diffusion on cytokine clearances and protein status. Am J Kidney Dis 2004;43:444-53.
20. Morgera S, Haase M, Kuss T, Vargas-Hein O, Zuckermann-Becker H, Melzer C et al. Pilot study on the effects of high cutoff hemofiltration on the need for norepinephrine in septic patients with acute renal failure. Crit Care Med 2006;34:2099-104.
21. Haase M, Bellomo R, Baldwin I, Haase-Fielitz A, Fealy N, Morgera S et al. Beta2-microglobulin removal and plasma albumin levels with high cut-off hemodialysis. Int J Artif Organs 2007;30:385-92.
22. Lee D, Haase M, Haase-Fielitz A, Paizis K, Goehl H, Bellomo R. A pilot, randomized, double-blind, cross-over study of high cut-off versus high-flux dialysis membranes. Blood Purif 2009;28:365-72.
23. Schmidt JJ, Hafer C, Clajus C, Hadem J, Beutel G, Schmidt BM et al. New high-cutoff dialyzer allows improved middle molecule clearance without an increase in albumin loss: a clinical crossover comparison in extended dialysis. Blood Purif 2012;34:246-52.
24. Cuoghi A, Caiazzo M, Monari E, Bellei E, Bergamini S, Sereni L et al. New horizon in dialysis depuration: characterization of a polysulfone membrane able to break the 'albumin wall'. J Biomater Appl 2014;29:1363-71.