A pilot, randomized, double-blind, cross-over study of high cut-off versus high-flux dialysis membranes

Blood Purification

Volumn 28, Issue 4, 2009, Pages 365-372

  Lee, Darren ^a   Haase, Michael ^b,c   Haase Fielitz, Anja ^b,c   Paizis, Kathy ^a   Goehl, Hermann ^d   Bellomo, Rinaldo ^a,b  

^a AUSTIN HOSPITAL   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d Gambro Dialysatoren GmbH   (Germany)

Author keywords

2 Microglobulin; Albumin; Haemodialysis; High cut off membranes; Middle molecules

Indexed keywords

BETA 2 MICROGLOBULIN; POLYSTYRENESULFONATE SODIUM; SERUM ALBUMIN; UREA;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CREATININE CLEARANCE; CROSSOVER PROCEDURE; DIALYSIS MEMBRANE; DOUBLE BLIND PROCEDURE; FEMALE; HEMODIALYSIS; HUMAN; HYPERKALEMIA; KIDNEY DISEASE; MALE; PRIORITY JOURNAL;

AGED; BETA 2-MICROGLOBULIN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MATERIALS TESTING; MEMBRANES, ARTIFICIAL; MIDDLE AGED; RENAL DIALYSIS; SERUM ALBUMIN; TREATMENT OUTCOME;

EID: 69549123836     PISSN: 02535068     EISSN: None     Source Type: Journal    
DOI: 10.1159/000235961     Document Type: Article

References (25)

1. Collins AJ, Foley R, Herzog C, et al: Excerpts from the United States Renal Data System 2007 annual data report. Am J Kidney Dis 2008; 51(suppl 1):S1-S320.
2. Vanholder R, Glorieux G, De Smet R, Lameire N: New insights in uremic toxins. Kidney Int Suppl 2003; 84:S6-S10.
3. Miyata T, Jadoul M, Kurokawa K, Van Ypersele de Strihou C: Beta-2 microglobulin in renal disease. J Am Soc Nephrol 1998; 9: 1723-1735.
4. Canaud B, Morena M, Cristol JP, Krieter D: Beta2-microglobulin, a uremic toxin with a double meaning. Kidney Int 2006; 69: 1297-1299.
5. Cheung AK, Rocco MV, Yan G, et al: Serum beta-2 microglobulin levels predict mortality in dialysis patients: Results of the HEMO study. J Am Soc Nephrol 2006; 17: 546-555.
6. Okuno S, Ishimura E, Kohno K, Fujino- Katoh Y, Maeno Y, Yamakawa T, Inaba M, Nishizawa Y: Serum beta2-microglobulin level is a significant predictor of mortality in maintenance haemodialysis patients. Nephrol Dial Transplant 2009; 24: 571-577.
7. Santoro A, Mancini E, Bolzani R, Boggi R, Cagnoli L, Francioso A, Fusaroli M, Piazza V, Rapanà R, Strippoli GF: The effect of online high-flux hemofiltration versus lowflux hemodialysis on mortality in chronic kidney failure: A small randomized controlled trial. Am J Kidney Dis 2008; 52: 507-518.
8. Meert N, Eloot S, Waterloos MA, Van Landschoot M, Dhondt A, Glorieux G, Ledebo I, Vanholder R: Effective removal of proteinbound uraemic solutes by different convective strategies: A prospective trial. Nephrol Dial Transplant 2009; 24: 562-570.
9. Abe T, Uchita K, Orita H, Kamimura M, Oda M, Hasegawa H, Kobata H, Fukunishi M, Shimazaki M, Abe T, Akizawa T, Ahmad S: Effect of beta(2)-microglobulin adsorption column on dialysis-related amyloidosis. Kidney Int 2003; 64: 1522-1528.
10. Goldfarb-Rumyantzev AS, Leypoldt JK, Nelson N, et al: A crossover study of short daily haemodialysis. Nephrol Dial Transplant 2006; 21: 166-175.
11. Eloot S, Van Biesen W, Dhondt A, Van de Wynkele H, Glorieux G, Verdonck P, Vanholder R: Impact of hemodialysis duration on the removal of uremic retention solutes. Kidney Int 2008; 73: 765-770.
12. Pellicano R, Polkinghorne KR, Kerr PG: Reduction in beta2-microglobulin with superflux versus high-flux dialysis membranes: Results of a 6-week, randomized, doubleblind, crossover trial. Am J Kidney Dis 2008; 52: 93-101.
13. Bonomini M, Fiederling B, Bucciarelli T, Manfrini V, Di Ilio C, Albertazzi A: A new polymethylmethacrylate membrane for hemodialysis. Int J Artif Organs 1996; 19: 232-239.
14. Galli F, Benedetti S, Floridi A, et al: Glycoxidation and inflammatory markers in patients on treatment with PMMA-based protein- leaking dialyzers. Kidney Int 2005; 67: 750-759.
15. Van Tellingen A, Grooteman MP, Bartels PC, et al: Long-term reduction of plasma homocysteine levels by super-flux dialyzers in hemodialysis patients. Kidney Int 2001; 59: 342-347.
16. Stein G, Franke S, Mahiout A, et al: Influence of dialysis modalities on serum AGE levels in end-stage renal disease patients. Nephrol Dial Transplant 2001; 16: 999-1008.
17. Haase M, Bellomo R, Baldwin I, Haase- Fielitz A, Fealy N, Davenport P, Morgera S, Goehl H, Storr M, Boyce N, Neumayer HH: Hemodialysis membrane with a high-molecular- weight cutoff and cytokine levels in sepsis complicated by acute renal failure: A phase 1 randomized trial. Am J Kidney Dis 2007; 50: 296-304.
18. Haase M, Bellomo R, Baldwin I, Haase- Fielitz A, Fealy N, Morgera S, Goehl H, Storr M, Boyce N, Neumayer HH: Beta2-microglobulin removal and plasma albumin levels with high cut-off hemodialysis. Int J Artif Organs 2007; 30: 385-392.
19. Locatelli F, Martin-Malo A, Hannedouche T, Loureiro A, Papadimitriou M, Wizemann V, Jacobson SH, Czekalski S, Ronco C, Vanholder R; Membrane Permeability Outcome (MPO) Study Group: Effect of membrane permeability on survival of hemodialysis patients. J Am Soc Nephrol 2009; 20: 645-654.
20. Ward RA, Schmidt B, Hullin J, Hillebrand GF, Samtleben W: A comparison of on-line hemodiafiltration and high-flux hemodialysis: A prospective clinical study. J Am Soc Nephrol 2000; 11: 2344-2350.
21. Penne EL, Blankestijn PJ, Bots ML, van den Dorpel MA, Grooteman MP, Nube MJ, ter Wee PM: Resolving controversies regarding hemodiafiltration versus hemodialysis: The Dutch Convective Transport Study. Semin Dial 2005; 18: 47-51.
22. Owen WF Jr, Lew NL, Liu Y, Lowrie EG, Lazarus JM: The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 1993; 329: 1001-1006.
23. Galli F, Benedetti S, Floridi A, Canestrari F, Piroddi M, Buoncristiani E, Buoncristiani U: Glycoxidation and inflammatory markers in patients on treatment with PMMAbased protein-leaking dialyzers. Kidney Int 2005; 67: 750-759.
24. Eknoyan G, Beck GJ, Cheung AK, Daugirdas JT, Greene T, Kusek JW, Allon M, Bailey J, Delmez JA, Depner TA, Dwyer JT, Levey AS, Levin NW, Milford E, Ornt DB, Rocco MV, Schulman G, Schwab SJ, Teehan BP, Toto R; Hemodialysis (HEMO) Study Group: Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002; 347: 2010-2019.
25. Ward RA: Protein-leaking membranes for hemodialysis: A new class of membranes in search of an application? J Am Soc Nephrol 2005; 16: 2421-2430.