Epigenetic upregulation of metabotropic glutamate receptor 2 in the spinal cord attenuates oestrogeninduced visceral hypersensitivity

Gut

Volumn 64, Issue 12, 2015, Pages 1913-1920

  Cao, Dong Yuan ^a   Bai, Guang ^a   Ji, Yaping ^a   Traub, Richard J ^a  

^a UNIVERSITY OF MARYLAND DENTAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 2 (2 CARBOXYCYCLOPROPYL) 3 (XANTHEN 9 YL)PROPIONIC ACID; ESTRADIOL; ESTROGEN; ESTROGEN RECEPTOR ALPHA; HISTONE DEACETYLASE; HISTONE H3; MESSENGER RNA; METABOTROPIC RECEPTOR 2; SAFFLOWER OIL; VORINOSTAT; AMINO ACID; HISTONE; HISTONE DEACETYLASE INHIBITOR; HYDROXAMIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 3; XANTHENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME INHIBITION; EPIGENETICS; FEMALE; HISTONE ACETYLATION; METABOTROPIC GLUTAMATE RECEPTOR 2 GENE; MOLECULAR INTERACTION; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; RAT; RECEPTOR UPREGULATION; SPINAL CORD; STIMULUS RESPONSE; VISCERAL PAIN; VISCEROMOTOR RESPONSE; ACETYLATION; ANIMAL; ANTAGONISTS AND INHIBITORS; DISEASE MODEL; DRUG EFFECTS; GENETIC EPIGENESIS; GENETICS; METABOLISM; NOCICEPTION; OVARIECTOMY; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; UPREGULATION; VISCERA;

ACETYLATION; AMINO ACIDS; ANIMALS; DISEASE MODELS, ANIMAL; EPIGENESIS, GENETIC; ESTRADIOL; ESTROGENS; FEMALE; HISTONE DEACETYLASE INHIBITORS; HISTONES; HYDROXAMIC ACIDS; NOCICEPTION; OVARIECTOMY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, METABOTROPIC GLUTAMATE; RNA, MESSENGER; SPINAL CORD; UP-REGULATION; VISCERA; VISCERAL PAIN; XANTHENES;

EID: 84954306387     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2014-307748     Document Type: Article

References (32)

1. Mulak A, Tache Y, Larauche M. Sex hormones in the modulation of irritable bowel syndrome. World J Gastroenterol 2014;20:2433-48.
2. Traub RJ, Ji Y. Sex differences and hormonal modulation of deep tissue pain. Front Neuroendocrinol 2013;34:350-66.
3. Ji Y, Tang B, Traub RJ. Spinal estrogen receptor alpha mediates estradiol-induced pronociception in a visceral pain model in the rat. Pain 2011;152:1182-91.
4. Ji Y, Murphy AZ, Traub RJ. Estrogen modulates the visceromotor reflex and responses of spinal dorsal horn neurons to colorectal stimulation in the rat. J Neurosci 2003;23:3908-15.
5. Safe S, Kim K. Non-classical genomic estrogen receptor (ER)/specificity protein and ER/activating protein-1 signaling pathways. J Mol Endocrinol 2008;41:263-75.
6. Graff J, Kim D, Dobbin MM, et al. Epigenetic regulation of gene expression in physiological and pathological brain processes. Physiol Rev 2011;91:603-49.
7. Portela A, Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010;28:1057-68.
8. Varela MA, Roberts TC, Wood MJ. Epigenetics and ncRNAs in brain function and disease: mechanisms and prospects for therapy. Neurotherapeutics 2013;10:621-31.
9. Zhang Z, Cai YQ, Zou F, et al. Epigenetic suppression of GAD65 expression mediates persistent pain. Nat Med 2011;17:1448-55.
10. Bai G, Wei D, Zou S, et al. Inhibition of class II histone deacetylases in the spinal cord attenuates inflammatory hyperalgesia. Mol Pain 2010;6:51.
11. Chiechio S, Zammataro M, Morales ME, et al. Epigenetic modulation of mGlu2 receptors by histone deacetylase inhibitors in the treatment of inflammatory pain. Mol Pharmacol 2009;75:1014-20.
12. Denk F, Huang W, Sidders B, et al. HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain. Pain 2013;154:1668-79.
13. Denk F, McMahon S. Chronic pain: emerging evidence for the involvement of epigenetics. Neuron 2012;73:435-44.
14. Tang B, Ji Y, Traub RJ. Estrogen alters spinal NMDA receptor activity via a PKA signaling pathway in a visceral pain model in the rat. Pain 2008;137:540-9.
15. Bai G, Ambalavanar R, Wei D, et al. Downregulation of selective microRNAs in trigeminal ganglion neurons following inflammatory muscle pain. Mol Pain 2007;3:15.
16. Liu A, Hoffman PW, Lu W, et al. NF-kappaB site interacts with Sp factors and up-regulates the NR1 promoter during neuronal differentiation. J Biol Chem 2004;279:17449-58.
17. Mukhopadhyay A, Deplancke B, Walhout AJ, et al. Chromatin immunoprecipitation (ChIP) coupled to detection by quantitative real-time PCR to study transcription factor binding to DNA in Caenorhabditis elegans. Nat Protoc 2008;3:698-709.
18. Mason CE, Shu FJ, Wang C, et al. Location analysis for the estrogen receptor-alpha reveals binding to diverse ERE sequences and widespread binding within repetitive DNA elements. Nucleic Acids Res 2010;38:2355-68.
19. Chiechio S, Copani A, De PL, et al. Transcriptional regulation of metabotropic glutamate receptor 2/3 expression by the NF-kappaB pathway in primary dorsal root ganglia neurons: a possible mechanism for the analgesic effect of L-acetylcarnitine. Mol Pain 2006;2:20.
20. Boulware MI, Weick JP, Becklund BR, et al. Estradiol activates group I and II metabotropic glutamate receptor signaling, leading to opposing influences on cAMP response element-binding protein. J Neurosci 2005;25:5066-78.
21. Boulware MI, Mermelstein PG. Membrane estrogen receptors activate metabotropic glutamate receptors to influence nervous system physiology. Steroids 2009;74:608-13.
22. Jin VX, Sun H, Pohar TT, et al. ERTargetDB: an integral information resource of transcription regulation of estrogen receptor target genes. J Mol Endocrinol 2005;35:225-30.
23. Pradhan M, Baumgarten SC, Bembinster LA, et al. CBP mediates NF-kappaB-dependent histone acetylation and estrogen receptor recruitment to an estrogen response element in the BIRC3 promoter. Mol Cell Biol 2012;32:569-75.
24. Bai G, Hoffman PW. Transcriptional regulation of NMDA receptor expression. In: Van Dongen AM, ed. Biology of the NMDA receptor. Boca Raton, FL: CRC press, 2009;79-101.
25. DiRenzo J, Shang Y, Phelan M, et al. BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation. Mol Cell Biol 2000;20:7541-9.
26. Chen H, Lin RJ, Xie W, et al. Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase. Cell 1999;98:675-86.
27. Wang Z, Zang C, Rosenfeld JA, et al. Combinatorial patterns of histone acetylations and methylations in the human genome. Nat Genet 2008;40:897-903.
28. Kapranov P, Willingham AT, Gingeras TR. Genome-wide transcription and the implications for genomic organization. Nat Rev Genet 2007;8:413-23.
29. Tran L, Chaloner A, Sawalha AH, et al. Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress. Psychoneuroendocrinology 2013;38:898-906.
30. Jiang Y, Langley B, Lubin FD, et al. Epigenetics in the nervous system. J Neurosci 2008;28:11753-9.
31. West AC, Johnstone RW. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest 2014;124:30-9.
32. Slingerland M, Guchelaar HJ, Gelderblom H. Histone deacetylase inhibitors: an overview of the clinical studies in solid tumors. Anticancer Drugs 2014;25:140-9.