Systematic and comprehensive investigation of the toxicity of curcuminoid-essential oil complex: A bioavailable turmeric formulation

Molecular Medicine Reports

Volumn 13, Issue 1, 2016, Pages 592-604

  Aggarwal, Madan L ^a   Chacko, Karampendethu M ^a   Kuruvilla, Binu T ^b  

^a SHRIRAM INSTITUTE FOR INDUSTRIAL RESEARCH   (India)

^b Arjuna Natural Extracts Ltd   (India)

Author keywords

Ames test; Curcuma longa; Curcumin; Mammalian bone marrow chromosome aberration test; Mutagenicity studies; Toxicity

Indexed keywords

CORN OIL; CURCUMIN; CURCUMINOID ESSENTIAL OIL; CYCLOPHOSPHAMIDE; ESSENTIAL OIL; TURMERIC; UNCLASSIFIED DRUG;

ACUTE TOXICITY; AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME ABERRATION; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG MEGADOSE; DRUG SAFETY; FEMALE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; LD50; LETHAL DOSE; LOW DRUG DOSE; MALE; METAPHASE; MICRONUCLEUS TEST; MORTALITY; MOUSE; MUTAGENICITY; NONHUMAN; RAT; RECOMMENDED DRUG DOSE; REPEATED DRUG DOSE; REVERTANT; TREATMENT DURATION; ANIMAL; ANTIBODY SPECIFICITY; BIOAVAILABILITY; BONE MARROW; DRUG EFFECTS; ERYTHROCYTE; MEDICINAL CHEMISTRY; PATHOLOGY; TOXICITY TESTING; WEIGHT GAIN; WISTAR RAT;

ANIMALS; BIOLOGICAL AVAILABILITY; BONE MARROW; CHEMISTRY, PHARMACEUTICAL; CHROMOSOME ABERRATIONS; CURCUMIN; ERYTHROCYTES; FEMALE; MALE; MICE; MICRONUCLEUS TESTS; OILS, VOLATILE; ORGAN SPECIFICITY; RATS, WISTAR; TOXICITY TESTS, ACUTE; WEIGHT GAIN;

EID: 84954290806     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2015.4579     Document Type: Article

References (32)

1. Ravindran PN, Nirmal Babu K, Sivaraman K. Turmeric. The golden spice of life. In: Turmeric. The Genus Curcuma. Boca Raton, FL, USA: CRC Press; 2007. P. 1-14.
2. Maheshwari RK, Singh AK, Gaddipati J and Srimal RC: Multiple biological effects of curcumin: A short review. Life Sci 78: 2081-2087, 2006.
3. Chandra D and Gupta SS: Anti-inflammatory and anti-arthritic activity of volatile oil of Curcuma longa (Haldi). Indian J Med Res 60: 138-142, 1972.
4. Aggarwal BB, Sundaram C, Malani N and Ichikawa H: Curcumin: The Indian solid gold. Adv Exp Med Biol 595: 1-75, 2007.
5. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421, 2006.
6. Sharma RA, Gescher AJ and Steward WP: Curcumin: The story so far. Eur J Cancer 41: 1955-1968, 2005.
7. Duvoix A, Blasius R, Delhalle S, Schnekenburger M, Morceau F, Henry E, Dicato M and Diederich M: Chemopreventive and therapeutic effects of curcumin. Cancer Lett 223: 181-190, 2005.
8. Joe B, Vijayakumar M and Lokesh BR: Biological properties of curcumin-cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44: 97-111, 2004.
9. Menon LG, Kuttan R and Kuttan G: Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Lett 95: 221-225, 1995.
10. Menon LG, Kuttan R and Kuttan G: Anti-metastatic activity of curcumin and catechin. Cancer Lett 141: 159-165, 1999.
11. Chen HW, Yu SL, Chen JJ, Li HN, Lin YC, Yao PL, Chou HY, Chien CT, Chen WJ, Lee YT and Yang PC: Anti-invasive gene expression profile of curcumin in lung adenocarcinoma based on a high throughput microarray analysis. Mol Pharmacol 65: 99-110, 2004.
12. Tønnesen HH, Másson M and Loftsson T: Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: Solubility, chemical and photochemical stability. Int J Pharm 244: 127-135, 2002.
13. Pan MH, Huang TM and Lin JK: Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos 27: 486-494, 1999.
14. Johnson JJ and Mukhtar H: Curcumin for chemoprevention of colon cancer. Cancer Lett 255: 170-181, 2007.
15. Sharma RA, Euden SA, Platton SL, Cooke DN, Shafayat A, Hewitt HR, Marczylo TH, Morgan B, Hemingway D, Plummer SM, et al: Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin Cancer Res 10: 6847-6854, 2004.
16. Anand P, Kunnumakkara AB, Newman RA and Aggarwal BB: Bioavailability of curcumin: Problems and promises. Mol Pharm 4: 807-818, 2007.
17. Cui J, Yu B, Zhao Y, Zhu W, Li H, Lou H and Zhai G: Enhancement of oral absorption of curcumin by self-microemulsifying drug delivery systems. Int J Pharm 371: 148-155, 2009.
18. Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP and Gescher AJ: Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol 60: 171-177, 2007.
19. Ganiger S, Malleshappa HN, Krishnappa H, Rajashekhar G, Ramakrishna Rao V and Sullivan F: A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem Toxicol 45: 64-69, 2007.
20. Shankar TN, Shantha NV, Ramesh HP, Murthy IA and Murthy VS: Toxicity studies on turmeric (Curcuma longa): Acute toxicity studies in rats, guineapigs and monkeys. Indian J Exp Biol 18: 73-75, 1980.
21. Ravindranath V and Chandrasekhara N: Absorption and tissue distribution of curcumin in rats. Toxicology 16: 259-265, 1980.
22. Wahlström B and Blennow G: A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol (Copenh) 43: 86-92, 1978.
23. Burgos-Morón E, Calderón-Montaño JM, Salvador J, Robles A and López-Lázaro M: The dark side of curcumin. Int J Cancer 126: 1771-1775, 2010.
24. Kizhakkedath R: Clinical evaluation of a formulation containing Curcuma longa and Boswellia serrata extracts in the management of knee osteoarthritis. Mol Med Rep 8: 1542-1548, 2013.
25. EFSA Panel on Food Additives and Nutrient Sources added to Food (ANS); Scientific Opinion on the reevaluation of curcumin (E 100) as a food additive. EFSA Journal 8: 1679, 2010.
26. Joint FAO/WHO Expert Committee on Food Additives (JECFA): Summary and conclusions of the sixty-first meeting. JECF, Rome, Italy, pp1-22, 2010.
27. Henrotin Y, Priem F and Mobasheri A: Curcumin: A new paradigm and therapeutic opportunity for the treatment of osteoarthritis: curcumin for osteoarthritis management. Springerplus. doi: 10-1186/2193-1801-2-56.
28. Antony B, Merina B, Iyer VS, Judy N, Lennertz K and Joyal S: A pilot cross-over study to evaluate human oral bioavailability of BCM-95CG (Biocurcumax), a novel bioenhanced preparation of Curcumin. Indian J Pharm Sci 70: 445-449, 2008.
29. OECD Guidelines for Testing of Chemicals: Acute oral toxicity-fixed dose procedure, test no. 420. Organisation for Economic Co-operation and Development. Paris, France, pp1-14, 2002.
30. Parasuraman S: Toxicological screening. J Pharmacol Pharmacother 2: 74-79, 2011.
31. Maron DM and Ames BN: Revised methods for the Salmonella mutagenicity test. Mutat Res 113: 173-215, 1983.
32. Schmid W: The micronucleus test. Mutat Res 31: 9-15, 1975.