PLASMA OXYTOCIN CONCENTRATION and DEPRESSIVE SYMPTOMS: A REVIEW of CURRENT EVIDENCE and DIRECTIONS for FUTURE RESEARCH

Depression and Anxiety

Volumn 33, Issue 4, 2016, Pages 316-322

  Massey, Suena H ^a   Backes, Katherine A ^a   Schuette, Stephanie A ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

biological markers; depressive disorder; humans; neuropeptides; pregnancy

Indexed keywords

OXYTOCIN; SEX HORMONE;

AGE; DEPRESSION; DISEASE SEVERITY; ETHNICITY; GENDER; HUMAN; INFORMATION RETRIEVAL; MEDLINE; MOOD; NONHUMAN; OXYTOCIN BLOOD LEVEL; OXYTOCIN RELEASE; PATHOGENESIS; PREGNANT WOMAN; PRIORITY JOURNAL; PSYCINFO; RACE; REVIEW; SAMPLE SIZE; SOCIAL BEHAVIOR; STRESS; ADULT; ANIMAL; BLOOD; FEMALE; MALE; PREGNANCY; PSYCHOLOGY; SEVERITY OF ILLNESS INDEX;

ADULT; ANIMALS; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; OXYTOCIN; PREGNANCY; SEVERITY OF ILLNESS INDEX;

EID: 84954290704     PISSN: 10914269     EISSN: 15206394     Source Type: Journal    
DOI: 10.1002/da.22467     Document Type: Review

References (43)

1. Fawcett J., The morbidity and mortality of clinical depression. Int Clin Psychopharmacol 1993; 8 (4): 217-220.
2. Control, CfD and Prevention. Prevalence of current depression∗ among persons aged ≥12 years, by age group and sex-united states, national health and nutrition examination survey, 2007-2010. 2012; 1747.
3. Souery D, Papakostas GI, Trivedi MH,. Treatment-resistant depression. J Clin Psychiatry 2006; 67: 16-22.
4. Fava M, Uebelacker LA, Alpert JE, Nierenberg AA, Pava JA, Rosenbaum JF,. Major depressive subtypes and treatment response. Biol Psychiatry 1997; 42 (7): 568-576.
5. Schneider B, Prvulovic D,. Biomarkers for depression. General Methods in Biomarker Research and their Applications. Dordrecht: Springer Science+Business Media. 2015: 957-978.
6. Hirschfeld R., History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry 2000; 61 (Suppl 6): 4-6.
7. Pariante, CM, Lightman, SL., The HPA axis in major depression: classical theories and new developments. Trends Neurosci 2008; 31 (9): 464-468.
8. Gimpl G, Fahrenholz F, The oxytocin receptor system: structure, function, and regulation. Physiol Rev 2001; 81 (2): 629-683.
9. Winslow JT, Shapiro L, Carter CS, Insel TR,. Oxytocin and complex social behavior: species comparisons. Psychopharmacol Bull 1993; 29 (3): 409-414.
10. Carter CS., Developmental consequences of oxytocin. Physiol Behav 2003; 79: 383-397.
11. Arletti R, Bertolini A., Oxytocin acts as an antidepressant in two animal models of depression. Life Sci 1987; 41: 1725-1730.
12. Anacker AM, Beery AK., Life in groups: the roles of oxytocin in mammalian sociality. Front Behav Neurosci 2013; 7: 1-10.
13. Insel TR, Young LJ., The neurobiology of attachment. Nat Rev Neurosci 2001; 2: 129-136.
14. Neumann ID., Brain oxytocin: a key regulator of emotional and social behaviours in both females and males. J Neuroendocrinol 2008; 20: 858-865.
15. McQuaid RJ, McInnis OA, Abizaid A, Anisman H., Making room for oxytocin in understanding depression. Neurosci Biobehav Rev 2014; 45: 305-322.
16. Eapen V, Dadds M, Barnett B, et al., Separation anxiety, attachment and inter-personal representations: disentangling the role of oxytocin in the perinatal period. PLoS One 2014; 9: e107745.
17. Zelkowitz P, Gold I, Feeley N, et al., Psychosocial stress moderates the relationships between oxytocin, perinatal depression, and maternal behavior. Horm Behav 2014; 66: 351-360.
18. Cyranowski JM, Hofkens TL, Frank E, et al., Evidence of dysregulated peripheral oxytocin release among depressed women. Psychosom Med 2008; 70: 967-975.
19. Skrundz M, Bolten M, Nast I, et al., Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology 2011; 36: 1886-1893.
20. Seay JS, Lattie E, Schneiderman N, et al., Linear and quadratic associations of plasma oxytocin with depressive symptoms in ethnic minority women living with HIV. J Appl Biobehav Res 2014; 19: 70-78.
21. Ozsoy S, Esel E, Kula M,. Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment. Psychiatry Res 2009; 169: 249-252.
22. Yuen KW, Garner JP, Carson DS, et al., Plasma oxytocin concentrations are lower in depressed vs. Healthy control women and are independent of cortisol. J Psychiatr Res 2014; 51: 30-36.
23. Turan T, Uysal C AA, Kbox drawings light down and leftlbox drawings light down and leftç E,. May oxytocin be a trait marker for bipolar disorder? Psychoneuroendocrinology 2013; 38: 2890-2896.
24. Bergant A, Nguyen T, Heim K, et al., [German language version and validation of the edinburgh postnatal depression scale]. Deutsche medizinische Wochenschrift 1998; 123: 35-40.
25. Cox JL, Holden JM, Sagovsky R,. Detection of postnatal depression. Development of the 10-item edinburgh postnatal depression scale. British J Psychiatry 1987; 150: 782-786.
26. Austin MP, Hadzi-Pavlovic D, Saint K, Parker G,. Antenatal screening for the prediction of postnatal depression: validation of a psychosocial pregnancy risk questionnaire. Acta Psychiatr Scand 2005; 112: 310-317.
27. Beck AT, Steer RA, Carbin MG,. Psychometric properties of the beck depression inventory: twenty-five years of evaluation. Clin Psychol Rev 1988; 8: 77-100.
28. Windle RJ, Shanks N, Lightman SL, Ingram CD., Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats 1. Endocrinology 1997; 138 (7): 2829-2834.
29. Taylor SE, Klein LC, Lewis BP, Gruenewald TL, Gurung, RA, Updegraff, JA, Biobehavioral responses to stress in females: tend-and-befriend, not fight-or-flight. Psychol Rev 2000; 107 (3): 411-429.
30. Grippo AJ, Cushing BS, Carter CS., Depression-like behavior and stressor-induced neuroendocrine activation in female prairie voles exposed to chronic social isolation. Psychosom Med 2007; 69 (2): 149-157.
31. Neumann ID, Krömer SA, Toschi N, Ebner K., Brain oxytocin inhibits the (re) activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions. Regul Pept 2000; 96 (1): 31-38.
32. Rotzinger S, Lovejoy DA, Tan LA., Behavioral effects of neuropeptides in rodent models of depression and anxiety. Peptides 2010; 31 (4): 736-756.
33. Rodrigues SM, Saslow LR, Garcia N, John OP, Keltner D., Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans. Proc Natl Acad Sci 2009; 106 (50): 21437-21441.
34. Chen FS, Kumsta R, von Dawans B, Monakhov M, Ebstein PR, Heinrichs M., Common oxytocin receptor gene (OXTR) polymorphism and social support interact to reduce stress in humans. Proc Natl Acad Sci 2011; 108 (50): 19937-19942.
35. Nomura M, McKenna E, Korach KS, Pfaff DW, Ogawa S,. Estrogen receptor-beta regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice. Brain Res Mol Brain Res 2002; 109: 84-94.
36. Fuchs AR., Oxytocin and ovarian function. J Reprod Fertil Suppl 1987; 36: 39-47.
37. Nusslock R, Young CB, Damme KS,. Elevated reward-related neural activation as a unique biological marker of bipolar disorder: assessment and treatment implications. Behav Res Ther 2014; 62: 74-87.
38. Insel TR, Shapiro LE., Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proc Natl Acad Sci 1992; 89: 5981-5985.
39. McCullough ME, Churchland PS, Mendez AJ,. Problems with measuring peripheral oxytocin: can the data on oxytocin and human behavior be trusted? Neurosci Biobehav Rev 2013; 37: 1485-1492.
40. Forsling ML., Diurnal rhythms in neurohypophysial function. Exp Physiol 2000; 85: 179S-186S.
41. Grewen KM, Light KC, Mechlin B, Girdler, SS,. Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women. Ethn Health 2008; 13 (3): 219-241.
42. Szeto A, McCabe PM, Nation DA, et al., Evaluation of enzyme immunoassay and radioimmunoassay methods for the measurement of plasma oxytocin. Psychosom Med 2011; 73 (5): 393-400.
43. Stix, G., Fact of Fiction? Oxytocin is the Love Hormone. Scientific American; September 8, 2014. Available at: http://www.scientificamerican.com/article/fact-or-fiction-oxytocin-is-the-love-hormone/.