Use of antidepressants and the risk of myocardial infarction in middle-aged and older adults: A matched case-control study

European Journal of Clinical Pharmacology

Volumn 72, Issue 2, 2016, Pages 211-218

  Noordam, Raymond ^a   Aarts, Nikkie ^a   Leening, Maarten J G ^a   Tiemeier, Henning ^a   Franco, Oscar H ^a   Hofman, Albert ^a   Stricker, Bruno H ^a,b   Visser, Loes E ^a,c  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b Netherlands Health Care Inspectorate   (Netherlands)

^c Apotheek Haagse Ziekenhuizen   (Netherlands)

Author keywords

Antidepressive agents; Case control studies; Myocardial infarction; Selective serotonin reuptake inhibitors; Serotonin

Indexed keywords

SEROTONIN UPTAKE INHIBITOR; TRICYCLIC ANTIDEPRESSANT AGENT; ANTIDEPRESSANT AGENT;

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; DEPRESSION; DRUG USE; FEMALE; FOLLOW UP; HEART INFARCTION; HUMAN; INCIDENCE; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; PRIORITY JOURNAL; PROSPECTIVE STUDY; STATISTICAL SIGNIFICANCE; MYOCARDIAL INFARCTION; NETHERLANDS; ODDS RATIO; RISK;

AGED; ANTIDEPRESSIVE AGENTS; CASE-CONTROL STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NETHERLANDS; ODDS RATIO; PROSPECTIVE STUDIES; RISK; SEROTONIN UPTAKE INHIBITORS;

EID: 84954270846     PISSN: 00316970     EISSN: 14321041     Source Type: Journal    
DOI: 10.1007/s00228-015-1972-2     Document Type: Article

References (35)

1. Fuller RW, Wong DT (1987) Serotonin reuptake blockers in vitro and in vivo. J Clin Psychopharmacol 7(6 Suppl):36S-43S
2. Ni W, Watts SW (2006) 5-hydroxytryptamine in the cardiovascular system: focus on the serotonin transporter (SERT). Clin Exp Pharmacol Physiol 33(7):575-583
3. Gomez-Gil E, Gasto C, Diaz-Ricart M, Carretero M, Salamero M, Catalan R, Escolar G (2002) Platelet 5-HT2A-receptor-mediated induction of aggregation is not altered in major depression. Hum Psychopharmacol 17(8):419-424. doi: 10.1002/hup.429
4. Schins A, Honig A, Crijns H, Baur L, Hamulyak K (2003) Increased coronary events in depressed cardiovascular patients: 5-HT2A receptor as missing Link? Psychosom Med 65(5):729-737
5. Sauer WH, Berlin JA, Kimmel SE (2001) Selective serotonin reuptake inhibitors and myocardial infarction. Circulation 104(16):1894-1898
6. Sauer WH, Berlin JA, Kimmel SE (2003) Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction. Circulation 108(1):32-36
7. Kimmel SE, Schelleman H, Berlin JA, Oslin DW, Weinstein RB, Kinman JL, Sauer WH, Lewis JD (2011) The effect of selective serotonin re-uptake inhibitors on the risk of myocardial infarction in a cohort of patients with depression. Br J Clin Pharmacol 72(3):514-517
8. Meier CR, Schlienger RG, Jick H (2001) Use of selective serotonin reuptake inhibitors and risk of developing first-time acute myocardial infarction. Br J Clin Pharmacol 52(2):179-184
9. Glassman AH, O'Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger JT, Jr., Krishnan KR, van Zyl LT, Swenson JR, Finkel MS, Landau C, Shapiro PA, Pepine CJ, Mardekian J, Harrison WM, Barton D, McLvor M, Sertraline Antidepressant Heart Attack Randomized Trial G (2002) Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA 288(6):701-709
10. Cohen HW, Gibson G, Alderman MH (2000) Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med 108(1):2-8
11. Coupland C, Dhiman P, Morriss R, Arthur A, Barton G, Hippisley-Cox J (2011) Antidepressant use and risk of adverse outcomes in older people: population based cohort study. BMJ 343:d4551
12. Blanchette CM, Simoni-Wastila L, Zuckerman IH, Stuart B (2008) A secondary analysis of a duration response association between selective serotonin reuptake inhibitor use and the risk of acute myocardial infarction in the aging population. Ann Epidemiol 18(4):316-321
13. Barefoot JC, Schroll M (1996) Symptoms of depression, acute myocardial infarction, and total mortality in a community sample. Circulation 93(11):1976-1980
14. Ford DE, Mead LA, Chang PP, Cooper-Patrick L, Wang NY, Klag MJ (1998) Depression is a risk factor for coronary artery disease in men: the precursors study. Arch Intern Med 158(13):1422-1426
15. Frasure-Smith N, Lesperance F, Talajic M (1995) Depression and 18-month prognosis after myocardial infarction. Circulation 91(4):999-1005
16. Penninx BW, Beekman AT, Honig A, Deeg DJ, Schoevers RA, van Eijk JT, van Tilburg W (2001) Depression and cardiac mortality: results from a community-based longitudinal study. Arch Gen Psychiatry 58(3):221-227
17. Pratt LA, Ford DE, Crum RM, Armenian HK, Gallo JJ, Eaton WW (1996) Depression, psychotropic medication, and risk of myocardial infarction. Prospective data from the Baltimore ECA follow-up. Circulation 94(12):3123-3129
18. Stewart RA, North FM, West TM, Sharples KJ, Simes RJ, Colquhoun DM, White HD, Tonkin AM, Long-Term Intervention With Pravastatin in Ischaemic Disease Study I (2003) Depression and cardiovascular morbidity and mortality: cause or Consequence? Eur Heart J 24(22):2027-2037
19. Hofman A, Grobbee DE, de Jong PT, van den Ouweland FA (1991) Determinants of disease and disability in the elderly: the Rotterdam elderly study. Eur J Epidemiol 7(4):403-422
20. Hofman A, Darwish Murad S, van Duijn CM, Franco OH, Goedegebure A, Ikram MA, Klaver CC, Nijsten TE, Peeters RP, Stricker BH, Tiemeier HW, Uitterlinden AG, Vernooij MW (2013) The Rotterdam study: 2014 objectives and design update. Eur J Epidemiol 28(11):889-926
21. WHO Collaboration Centre for Drug Statistics Methodology (2014) Guidelines for ATC Classification and DDD Assignment 2014. Avaialble at: http://www.whocc.no/atc-ddd-index/. Oslo: World Heath Organization (WHO) ATC/DDD Index (assessed on 22 September 2015)
22. Leening MJ, Kavousi M, Heeringa J, van Rooij FJ, Verkroost-van Heemst J, Deckers JW, Mattace-Raso FU, Ziere G, Hofman A, Stricker BH, Witteman JC (2012) Methods of data collection and definitions of cardiac outcomes in the Rotterdam study. Eur J Epidemiol 27(3):173-185. doi: 10.1007/s10654-012-9668-8
23. Raeder MB, Bjelland I, Emil Vollset S, Steen VM (2006) Obesity, dyslipidemia, and diabetes with selective serotonin reuptake inhibitors: the Hordaland health study. J Clin Psychiatry 67(12):1974-1982
24. Lara N, Archer SL, Baker GB, Le Melledo JM (2003) Paroxetine-induced increase in metabolic end products of nitric oxide. J Clin Psychopharmacol 23(6):641-645
25. Lara N, Baker GB, Archer SL, Le Melledo JM (2003) Increased cholesterol levels during paroxetine administration in healthy men. J Clin Psychiatry 64(12):1455-1459
26. Yoon JM, Cho EG, Lee HK, Park SM (2013) Antidepressant use and diabetes mellitus risk: a meta-analysis. Korean J Fam Med 34(4):228-240. doi: 10.4082/kjfm.2013.34.4.228
27. Kornstein SG, Schatzberg AF, Thase ME, Yonkers KA, McCullough JP, Keitner GI, Gelenberg AJ, Davis SM, Harrison WM, Keller MB (2000) Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry 157(9):1445-1452
28. Khan A, Brodhead AE, Schwartz KA, Kolts RL, Brown WA (2005) Sex differences in antidepressant response in recent antidepressant clinical trials. J Clin Psychopharmacol 25(4):318-324
29. Nagatomo T, Rashid M, Abul Muntasir H, Komiyama T (2004) Functions of 5-HT2A receptor and its antagonists in the cardiovascular system. Pharmacol Ther 104(1):59-81
30. Roth BL, Berry SA, Kroeze WK, Willins DL, Kristiansen K (1998) Serotonin 5-HT2A receptors: molecular biology and mechanisms of regulation. Crit Rev Neurobiol 12(4):319-338
31. Vikenes K, Farstad M, Nordrehaug JE (1999) Serotonin is associated with coronary artery disease and cardiac events. Circulation 100(5):483-489
32. Li N, Wallen NH, Ladjevardi M, Hjemdahl P (1997) Effects of serotonin on platelet activation in whole blood. Blood Coagul Fibrinolysis 8(8):517-523
33. Skop BP, Brown TM (1996) Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors. Psychosomatics 37(1):12-16
34. Taylor F, Huffman MD, Macedo AF, Moore TH, Burke M, Davey Smith G, Ward K, Ebrahim S (2013) Statins for the primary prevention of cardiovascular disease. The Cochrane Database of Systematic Reviews 1:CD004816
35. Meijer WE, Heerdink ER, Nolen WA, Herings RM, Leufkens HG, Egberts AC (2004) Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants. Arch Intern Med 164(21):2367-2370