Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration

Journal of Ginseng Research

Volumn 40, Issue 1, 2016, Pages 55-61

  Kim, Sungmin ^a   Kim, Min Soo ^a   Park, Kwanghoon ^a   Kim, Hyeon Joong ^a   Jung, Seok Won ^a   Nah, Seung Yeol ^a   Han, Jung Soo ^a   Chung, Chihye ^a  

^a Konkuk University   (South Korea)

Author keywords

Fear conditioning; Ginseng; Long term potentiation; Lysophosphatidic acid receptor; Synaptic plasticity

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GINSENG EXTRACT; GINTONIN; LYSOPHOSPHATIDIC ACID RECEPTOR; NOOTROPIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN SLICE; COGNITION; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; FEAR; FEAR CONDITIONING TEST; HIPPOCAMPAL CA1 REGION; LEARNING; LONG TERM POTENTIATION; MALE; MEMORY CONSOLIDATION; MEMORY TEST; MOUSE; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SCHAFFER COLLATERAL PATHWAY; WESTERN BLOTTING;

EID: 84954197941     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2015.05.001     Document Type: Article

References (33)

1. Lee YS, Silva AJ. The molecular and cellular biology of enhanced cognition. Nat Rev Neurosci 2009;10:126-140.
2. Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, et al. LPA receptors: subtypes and biological actions. Annu Rev Pharmacol Toxicol 2010;50:157-186.
3. Pilpel Y, Segal M. The role of LPA1 in formation of synapses among cultured hippocampal neurons. J Neurochem 2006;97:1379-1392.
4. Dash PK, Orsi SA, Moody M, Moore AN. A role for hippocampal Rho-ROCK pathway in long-term spatial memory. Biochem Biophys Res Commun 2004;322:893-898.
5. Park H, Kim S, Rhee J, Kim HJ, Han JS, Nah SY, Chung C. Synaptic enhancement induced by gintonin via lysophosphatidic acid receptor activation in central synapses. J Neurophysiol 2015;113:1493-1500.
6. Hwang SH, Shin TJ, Choi SH, Cho HJ, Lee BH, Pyo MK, Lee JH, Kang J, Kim HJ, Park CW, et al. Gintonin, newly identified compounds from ginseng, is novel lysophosphatidic acids-protein complexes and activates G protein-coupled lysophosphatidic acid receptors with high affinity. Mol Cells 2012;33:151-162.
7. Pyo MK, Choi SH, Shin TJ, Hwang SH, Lee BH, Kang J, Kim HJ, Lee SH, Nah SY. A simple method for the preparation of crude gintonin from ginseng root, stem, and leaf. J Ginseng Res 2011;35:209-218.
8. Nah SY. Gintonin: a novel ginseng-derived ligand that targets G proteincoupled lysophosphatidic acid receptors. Curr Drug Targets 2012;13:1659-1664.
9. Choi SH, Lee BH, Hwang SH, Kim HJ, Lee SM, Kim HC, Rhim HW, Nah SY. Molecular mechanisms of large-conductance ca (2+) -activated potassium channel activation by ginseng gintonin. Evid Based Complement Alternat Med 2013;2013:323709.
10. Nguyen PV, Abel T, Kandel ER, Bourtchouladze R. Strain-dependent differences in LTP and hippocampus-dependent memory in inbred mice. Learn Mem 2000;7:170-179.
11. Weeber EJ, Atkins CM, Selcher JC, Varga AW, Mirnikjoo B, Paylor R, Leitges M, Sweatt JD. A role for the beta isoform of protein kinase C in fear conditioning. J Neurosci 2000;20:5906-5914.
12. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Bio-chem 1976;72:248-254.
13. Hwang SH, Shin EJ, Shin TJ, Lee BH, Choi SH, Kang J, Kim HJ, Kwon SH, Jang CG, Lee JH, et al. Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing. J Alzheimers Dis 2012;31:207-223.
14. Kandel ER. The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB. Mol Brain 2012;5:14.
15. Bito H, Deisseroth K, Tsien RW. CREB phosphorylation and dephosphoryla-tion: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Cell 1996;87:1203-1214.
16. Gonzalez GA, Montminy MR. Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 1989;59:675-680.
17. Barco A, Alarcon JM, Kandel ER. Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell 2002;108:689-703.
18. Hall J, Thomas KL, Everitt BJ. Rapid and selective induction of BDNF expression in the hippocampus during contextual learning. Nat Neurosci 2000;3:533-535.
19. Liu IY, Lyons WE, Mamounas LA, Thompson RF. Brain-derived neurotrophic factor plays a critical role in contextual fear conditioning. J Neurosci 2004;24: 7958-7963.
20. Pedraza C, Sanchez-Lopez J, Castilla-Ortega E, Rosell-Valle C, Zambrana-Infantes E, Garcia-Fernandez M, Rodriguez de Fonseca F, Chun J, Santin LJ, Estivill-Torrus G. Fear extinction and acute stress reactivity reveal a role of LPA receptor in regulating emotional-like behaviors. Brain Struct Funct 2014;219:1659-1672.
21. Huang YZ, Chen RS, Rothwell JC, Wen HY. The after-effect of human theta burst stimulation is NMDA receptor dependent. Clin Neurophysiol 2007;118: 1028-1032.
22. Cohen AS, Raymond CR, Abraham WC. Priming of long-term potentiation induced by activation of metabotropic glutamate receptors coupled to phos-pholipase C. Hippocampus 1998;8:160-170.
23. Song C, Detert JA, Sehgal M, Moyer Jr JR. Trace fear conditioning enhances synaptic and intrinsic plasticity in rat hippocampus. J Neurophysiol 2012;107: 3397-3408.
24. Rex CS, Chen LY, Sharma A, Liu J, Babayan AH, Gall CM, Lynch G. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol 2009;186:85-97.
25. Lu Y, Christian K, Lu B. BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 2008;89:312-323.
26. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER. Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 1996;16:1137-1145.
27. Gruart A, Sciarretta C, Valenzuela-Harrington M, Delgado-Garcia JM, Minichiello L. Mutation at the TrkB PLCgamma-docking site affects hippo-campal LTP and associative learning in conscious mice. Learn Mem 2007;14: 54-62.
28. Minichiello L. TrkB signalling pathways in LTP and learning. Nat Rev Neurosci 2009;10:850-860.
29. Yoshii A, Constantine-Paton M. BDNF induces transport of PSD-95 to den-drites through PI3K-AKT signaling after NMDA receptor activation. Nat Neu-rosci 2007;10:702-711.
30. Mizuno M, Yamada K, Maekawa N, Saito K, Seishima M, Nabeshima T. CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning. Behav Brain Res 2002;133:135-141.
31. Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2001;2:599-609.
32. Gruart A, Benito E, Delgado-Garcia JM, Barco A. Enhanced cAMP response element-binding protein activity increases neuronal excitability, hippocampal long-term potentiation, and classical eyeblink conditioning in alert behaving mice. J Neurosci 2012;32:17431-17441.
33. Harrison SM, Reavill C, Brown G, Brown JT, Cluderay JE, Crook B, Davies CH, Dawson LA, Grau E, Heidbreder C, et al. LPA1 receptor-deficient mice have phenotypic changes observed in psychiatric disease. Mol Cell Neurosci 2003;24:1170-1179.