Correlation of circulating complement-fixing donor-specific antibodies identified by the C1q assay and presence of c4d in endomyocardial biopsy specimens

American Journal of Clinical Pathology

Volumn 145, Issue 1, 2016, Pages 62-68

  Frank, Renee ^a,b   Lal, Priti ^a   Kearns, Jane ^a   Molina, Maria R ^b   Wald, Joyce W ^b   Goldberg, Lee R ^a   Kamoun, Malek ^a  

^a Department of Pathology and Laboratory Medicine ^*  (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

C1q assay; C4d; Donor specific antibody; Endomyocardial biopsy

Indexed keywords

ANTIBODY; ANTIMETABOLITE; CALCINEURIN INHIBITOR; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C4D; CYCLOSPORIN; DONOR SPECIFIC ANTIBODY; IMMUNOGLOBULIN G; METHYLPREDNISOLONE SODIUM SUCCINATE; PREDNISONE; TACROLIMUS; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; ALLOANTIBODY; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; PEPTIDE FRAGMENT;

ACUTE GRAFT REJECTION; ACUTE HEART INFARCTION; ADULT; AGED; ANTIBODY MEDIATED REJECTION; CARDIAC GRAFT REJECTION; CLINICAL ARTICLE; COHORT ANALYSIS; COMPLEMENT FIXATION; CONFERENCE PAPER; CONTROLLED STUDY; CORRELATIONAL STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GRAFT DYSFUNCTION; GRAFT FAILURE; GRAFT RECIPIENT; HEART FAILURE; HEART MUSCLE BIOPSY; HEART TRANSPLANTATION; HUMAN; IMMUNOASSAY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IMMUNOSUPPRESSIVE TREATMENT; MALE; MEASUREMENT; MIDDLE AGED; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE ANTIGEN BEAD ASSAY; SOLID PHASE ASSAY; SOLID PHASE EXTRACTION; GRAFT REJECTION; IMMUNOLOGY; PATHOLOGY; YOUNG ADULT;

ADULT; AGED; COMPLEMENT C1Q; COMPLEMENT C4B; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; HUMANS; ISOANTIBODIES; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS; RETROSPECTIVE STUDIES; YOUNG ADULT;

EID: 84954184203     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1093/AJCP/AQV016     Document Type: Conference Paper

References (28)

1. Kobashigawa J, Crespo-Leiro MG, Ensminger SM, et al. Report from a consensus conference on antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2011;30:252-269
2. Stewart S, Winters GL, Fishbein MC, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. J Heart Lung Transplant. 2005;24:1710-1720
3. Berry GJ, Angelini A, Burke MM, et al. The ISHLT working formulation for pathologic diagnosis of antibody-mediated rejection in heart transplantation: evolution and current status (2005-2011). J Heart Lung Transplant. 2011;30:601-611
4. Kfoury AG, Stehlik J, Renlund DG, et al. Impact of repetitive episodes of antibody-mediated or cellular rejection on cardiovascular mortality in cardiac transplant recipients: defining rejection patterns. J Heart Lung Transplant. 2006;25:1277-1282
5. Bohmig GA, Exner M, Watschinger B, et al. C4d deposits in renal allografts are associated with inferior graft outcome. Transplant Proc. 2001;33:1151-1152
6. Shahzad K, Aziz QA, Leva JP, et al. New-onset graft dysfunction after heart transplantation-incidence and mechanismrelated outcomes. J Heart Lung Transplant. 2011;30:194-203
7. Colvin RB, Smith RN. Antibody-mediated organ-Allograft rejection. Nat Rev Immunol. 2005;5:807-817
8. Tan CD, Sokos GG, Pidwell DJ, et al. Correlation of donorspecific antibodies, complement and its regulators with graft dysfunction in cardiac antibody-mediated rejection. Am J Transplant. 2009;9:2075-2084
9. Herskowitz A, Soule LM, Ueda K, et al. Arteriolar vasculitis on endomyocardial biopsy: a histologic predictor of poor outcome in cyclosporine-treated heart transplant recipients. J Heart Transplant. 1987;6:127-136
10. Kfoury AG, Hammond ME, Snow GL, et al. Cardiovascular mortality among heart transplant recipients with asymptomatic antibody-mediated or stable mixed cellular and antibodymediated rejection. J Heart Lung Transplant. 2009;28:781-784
11. Takemoto SK, Zeevi A, Feng S, et al. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant. 2004;4:1033-1041
12. Baldwin WM, Kasper EK, et al. Beyond C4d: other complement-related diagnostic approaches to antibody-mediated rejection. Am J Transplant. 2004;4:311-318
13. Mehra MR, Crespo-Leiro MG, Dipchand A, et al. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010. J Heart Lung Transplant. 2010;29:717-727
14. Yabu JM, Higgins JP, Chen G, et al. C1q-fixing human leukocyte antigen antibodies are specific for predicting transplant glomerulopathy and late graft failure after kidney transplantation. Transplantation. 2011;91:342-347
15. Chin C, Chen G, Sequeria F, et al. Clinical usefulness of a novel C1q assay to detect immunoglobulin G antibodies capable of fixing complement in sensitized pediatric heart transplant patients. J Heart Lung Transplant. 2011;30:158-163
16. Zeevi A, Lunz J, Feingold B, et al. Persistent strong anti-HLA antibody at high titer is complement binding and associated with increased risk of antibody-mediated rejection in heart transplant recipients. J Heart Lung Transplant. 2013;32:98-105
17. Frank R, Molina MR, Wald JW, et al. Correlation of circulating donor-specific anti-HLA antibodies and presence of C4d in endomyocardial biopsy with heart allograft outcomes: a single-center, retrospective study. J Heart Lung Transplant. 2013;32:410-417
18. Braga JR, Santos IS, McDonald M, et al. Factors associated with the development of cardiac allograft vasculopathy-A systematic review of observational studies. Clin Transplant. 2012;26:E111-E124
19. Chen W, Thoburn CJ, Miura Y, et al. Autoimmune-mediated vasculopathy. Clin Immunol. 2001;100:57-70
20. de Denus S, Al-Jazairi A, Loh E, et al. Dyslipidemias and HMG-CoA reductase inhibitor prescription in heart transplant recipients. Ann Pharmacother. 2004;38:1136-1141
21. Kahn J, Rehak P, Schweiger M, et al. The impact of overweight on the development of diabetes after heart transplantation. Clin Transplant. 2006;20:62-66
22. McDonald K, Rector TS, Braulin EA, et al. Association of coronary artery disease in cardiac transplant recipients with cytomegalovirus infection. Am J Cardiol. 1989;64:359-362
23. Berry GJ, Burke MM, Andersen C, et al. The 2013 International Society for Heart and Lung TransplantationWorking Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2013;32:1147-1162
24. Reed EF, Demetris AJ, Hammond E, et al. Acute antibodymediated rejection of cardiac transplants. J Heart Lung Transplant. 2006;25:153-159
25. Fedrigo M, Gambino A, Benazzi E, et al. Role of morphologic parameters on endomyocardial biopsy to detect sub-clinical antibody-mediated rejection in heart transplantation. J Heart Lung Transplant. 2011;30:1381-1388
26. Hammond ME, Stehlik J, Snow G, et al. Utility of histologic parameters in screening for antibody-mediated rejection of the cardiac allograft: a study of 3, 170 biopsies. J Heart Lung Transplant. 2005;24:2015-2021
27. Stoica SC, Cafferty F, Pauriah M, et al. The cumulative effect of acute rejection on development of cardiac allograft vasculopathy. J Heart Lung Transplant. 2006;25:420-425
28. Amico P, Honger G, Bielmann D, et al. Incidence and prediction of early antibody-mediated rejection due to nonhuman leukocyte antigen-Antibodies. Transplantation. 2008;85:1557-1563