Fatal myocarditis associated with HHV-6 following immunosuppression in two children

Pediatrics

Volumn 137, Issue 1, 2016, Pages

  Stefanski, Heather E ^a   Thibert, Kathryn A ^a   Pritchett, Joshua ^a   Prusty, Bhupesh K ^b   Wagner, John E ^a   Lund, Troy C ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; CASE REPORT; COMPLICATION; FATALITY; FEMALE; HERPES VIRUS INFECTION; HUMAN; HUMAN HERPESVIRUS 6; IMMUNOCOMPROMISED PATIENT; MALE; MYOCARDITIS; PRESCHOOL CHILD;

ADOLESCENT; CHILD, PRESCHOOL; FATAL OUTCOME; FEMALE; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 6, HUMAN; HUMANS; IMMUNOCOMPROMISED HOST; MALE; MYOCARDITIS;

EID: 84954170583     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2015-1352     Document Type: Article

References (21)

1. Stone RC, Micali GA, Schwartz RA. Roseola infantum and its causal human herpesviruses. Int J Dermatol. 2014;53(4):397-403
2. Dulery R, Salleron J, Dewilde A, et al Early human herpesvirus type 6 reactivation after allogeneic stem cell transplantation: a large-scale clinical study. Biol Blood Marrow Transplant. 2012;18(7):1080-1089
3. Gotoh M, Yoshizawa S, Katagiri S, et al Human herpesvirus 6 reactivation on the 30th day after allogeneic hematopoietic stem cell transplantation can predict grade 2-4 acute graft-versus-host disease. Transpl Infect Dis. 2014;16(3):440-449
4. Hentrich M, Oruzio D, Jäger G, et al. Impact of human herpesvirus-6 after haematopoietic stem cell transplantation. Br J Haematol. 2005;128(1):66-72
5. Zerr DM, Corey L, Kim HW, Huang ML, Nguy L, Boeckh M. Clinical outcomes of human herpesvirus 6 reactivation after hematopoietic stem cell transplantation. Clin Infect Dis. 2005;40(7):932-940
6. Rohayem J, Dinger J, Fischer R, Klingel K, Kandolf R, Rethwilm A. Fatal myocarditis associated with acute parvovirus B19 and human herpesvirus 6 coinfection. J Clin Microbiol. 2001;39(12):4585-4587
7. Kühl U, Lassner D, Wallaschek N, et al. Chromosomally integrated human herpesvirus 6 in heart failure: prevalence and treatment. Eur J Heart Fail. 2015;17(1):9-19
8. Buyse S, Roque-Afonso AM, VaghefiP, et al. Acute hepatitis with periportal confluent necrosis associated with human herpesvirus 6 infection in liver transplant patients. Am J Clin Pathol. 2013;140(3):403-409
9. Leveque N, Boulagnon C, Brasselet C, et al A fatal case of Human Herpesvirus 6 chronic myocarditis in an immunocompetent adult. J Clin Virol. 2011;52(2):142-145
10. Andréoletti L, Lévêque N, Boulagnon C, Brasselet C, Fornes P. Viral causes of human myocarditis. Arch Cardiovasc Dis. 2009;102(6-7):559-568
11. Ashrafpoor G, Andréoletti L, Bruneval P, et al. Fulminant human herpesvirus 6 myocarditis in an immunocompetent adult: role of cardiac magnetic resonance in a multidisciplinary approach. Circulation. 2013;128(23):e445-e447
12. Kühl U, Pauschinger M, Noutsias M, et al. High prevalence of viral genomes and multiple viral infections in the myocardium of adults with "idiopathic" left ventricular dysfunction. Circulation. 2005;111(7):887-893
13. Kühl U, Pauschinger M, Seeberg B, et al. Viral persistence in the myocardium is associated with progressive cardiac dysfunction. Circulation. 2005;112(13):1965-1970
14. Mahrholdt H, Wagner A, Deluigi CC, et al. Presentation, patterns of myocardial damage, and clinical course of viral myocarditis. Circulation. 2006;114(15):1581-1590
15. Betts BC, Young JA, Ustun C, Cao Q, Weisdorf DJ. Human herpesvirus 6 infection after hematopoietic cell transplantation: is routine surveillance necessary? Biol Blood Marrow Transplant. 2011;17(10):1562-1568
16. Sakai R, Kanamori H, Motohashi K, et al Long-term outcome of human herpesvirus-6 encephalitis after allogeneic stem cell transplantation. Biol Blood Marrow Transplant. 2011;17(9):1389-1394
17. Scheurer ME, Pritchett JC, Amirian ES, Zemke NR, Lusso P, Ljungman P. HHV-6 encephalitis in umbilical cord blood transplantation: a systematic review and meta-analysis. Bone Marrow Transplant. 2013;48(4):574-580
18. Hakacova N, Klingel K, Kandolf R, Engdahl E, Fogdell-Hahn A, Higgins T. First therapeutic use of Artesunate in treatment of human herpesvirus 6B myocarditis in a child. J Clin Virol. 2013;57(2):157-160
19. Ishiyama K, Katagiri T, Ohata K, et al Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation. Transpl Infect Dis. 2012;14(1):33-39
20. Ishiyama K, Katagiri T, Hoshino T, Yoshida T, Yamaguchi M, Nakao S. Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT. Bone Marrow Transplant. 2011;46(6):863-869
21. Daubeney PE, Nugent AW, Chondros P, et al; National Australian Childhood Cardiomyopathy Study. Clinical features and outcomes of childhood dilated cardiomyopathy: results from a national population-based study. Circulation. 2006;114(24):2671-2678