Effect of Anserine/Carnosine Supplementation on Verbal Episodic Memory in Elderly People

Journal of Alzheimer's Disease

Volumn 50, Issue 1, 2016, Pages 149-159

  Hisatsune, Tatsuhiro ^a   Kaneko, Jun ^a   Kurashige, Hiroki ^a   Cao, Yuan ^a   Satsu, Hideo ^a   Totsuka, Mamoru ^a   Katakura, Yoshinori ^b   Imabayashi, Etsuko ^c   Matsuda, Hiroshi ^c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (Japan)

Author keywords

Alzheimer's disease; anserine and carnosine; cognitive function; dementia; elderly people; inflammatory cytokine; perfusion MRI; randomized controlled trial; verbal memory

Indexed keywords

ANSERINE; CARNOSINE; INTERLEUKIN 5; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; CYTOKINE;

ADULT; AGED; ARTICLE; BRAIN BLOOD FLOW; BRAIN PERFUSION; CONTROLLED STUDY; CYTOKINE RELEASE; DOUBLE BLIND PROCEDURE; EPISODIC MEMORY; FEMALE; HUMAN; MALE; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSTERIOR CINGULATE; PRIORITY JOURNAL; PSYCHOLOGIC TEST; RANDOMIZED CONTROLLED TRIAL; RECALL; VERBAL MEMORY; WECHSLER MEMORY SCALE; AGING; ANATOMY AND HISTOLOGY; BLOOD; BRAIN; DIETARY SUPPLEMENT; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; IMAGE PROCESSING; LEARNING; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST;

ADULT; AGED; AGING; ANSERINE; BRAIN; CARNOSINE; CYTOKINES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MEMORY, EPISODIC; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; VERBAL LEARNING;

EID: 84954162033     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-150767     Document Type: Article

References (47)

1. Baumgart M, SnyderHM,Carrillo MC, Fazio S, Kim H, Johns H (2015) Summary of the evidence on modifiable risk factors for cognitive decline and dementia: A population-based perspective. Alzheimers Dement 11, 718-726.
2. Lindenberger U (2014) Human cognitive aging: Corriger la fortune? Science 346, 572-578.
3. Gutchess A (2014) Plasticity of the aging brain: New directions in cognitive neuroscience. Science 346, 579-582.
4. Cooper JK (2014) Nutrition and the brain: What advice should we give? Neurobiol Aging (Suppl 2) 35, S79-S83.
5. Farías GA, Guzmán-Martínez L, Delgado C, Maccioni RB (2014) Nutraceuticals: A novel concept in prevention and treatment of Alzheimer's disease and related disorders. J Alzheimers Dis 42, 357-367.
6. Boldyrev AA, Aldini G, Derave W (2013) Physiology and pathophysiology of carnosine. Physiol Rev 93, 1803-1845.
7. Hipkiss AR (2007) Could carnosine or related structures suppress Alzheimer's disease? J Alzheimers Dis 11, 229-240.
8. Herculano B, Tamura M, Ohba A, Shimatani M, Kutsuna N, Hisatsune T (2013) alanyl-L-histidine rescues cognitive deficits caused by feeding a high fat diet in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 33, 983-997.
9. Szczes̈niak D, Budzeń S, Kopeć W, Rymaszewska J (2014) Anserine and carnosine supplementation in the elderly: Effects on cognitive functioning and physical capacity. Arch Gerontol Geriatr 59, 485-490.
10. Sugishita M (2001) Wechsler Memory Scale-Revised (Japanese) , Nihon Bunka Kagakusha, Tokyo.
11. Kawano N, Awata S, Ijuin M, Iwamoto K, Ozaki N (2013) Necessity of normative data on the Japanese version of the Wechsler Memory Scale-Revised Logical Memory subtest for old-old people. Geriatr Gerontol Int 13, 726-730.
12. Liu Y, Zhu X, Feinberg D, Guenther M, Gregori J, Weiner MW, Schuff N (2012) Arterial spin labeling MRI study of age and gender effects on brain perfusion hemodynamics. Magn Reson Med 68, 912-922.
13. Aoyagi S, Sugino T, Kajimoto Y, Nishitani M (2008) Safety of long-term administration of CBEX-Dr-containing drink of healthy people. Jpn Pharmacol Ther 36, 213-224.
14. Aoyagi S, Sugino T, Kajimoto Y, Nishitani M (2008) Safety of excess administration of CBEX-Dr-containing drink of healthy people. Jpn Pharmacol Ther 36, 225-235.
15. KiyoharaY, Shinohara A, Kato I, Shirota T,Kubo M, Tanizaki Y, Fujishima M, Iida M (2003) Dietary factors and development of impaired glucose tolerance and diabetes in a general Japanese population: The Hisayama Study. J Epidemiology 13, 251-258.
16. Homma A, Fukuzawa K, Tsukada Y, Ishii T, Hasegawa K, Mohs RC (1992) Development of a Japanese version of Alzheimer's disease Assessment Scale (ADAS) . Jpn J Geriatr Psychiatry 3, 647-655.
17. Mohs RC, Rosen WG, Davis KL (1983) The Alzheimer's Disease Assessment Scale: An instrument for assessing treatment efficacy. Psychopharmacol Bull 19, 448-450.
18. Beck AT, Steer RA, Brown GK (1996) Manual for the Beck Depression Inventory, 2nd Ed., Pearson, Texas.
19. Kojima M, Furukawa TA (2003) Japanese manual of the Beck Depression Inventory, 2nd ed., Nihon Bunka Kagakusha, Tokyo.
20. Ware JE, Sherbourne CD (1992) The MOS 36-item shortform health survey (SF-36) . I. Conceptual framework and item selection. Med Care 30, 474-483.
21. Lu Y, Nyunt MS, Gwee X, Feng L, Feng L, Kua EH, Kumar R, Ng TP (2012) Life event stress and chronic obstructive pulmonary disease (COPD): Associations with mental wellbeing and quality of life in a population-based study. BMJ Open 2, e001674.
22. Uchida K, Shan L, Suzuki H, Tabuse Y, Nishimura Y, HirokawaY, Mizukami K, Akatsu H, Meno K, AsadaT(2015) Amyloid-sequester proteins as blood-based biomarkers of cognitive decline. Alzheimers Dement (Amst) 1, 270-280.
23. Archary D, Liebenberg LJ, Werner L, Tulsi S, Majola N, Naicker N, Dlamini S, Hope TJ, Samsunder N, Abdool Karim SS, Morris L, Passmore JA, Garrett NJ (2015) Randomized cross-sectional study to compare HIV-1 specific antibody and cytokine concentrations in female genital secretions obtained by menstrual cup and cervicovaginal lavage. PLoS One 10, e0131906.
24. Benjamini Y, Hochberg Y (1995) Controlling false discovery rate: A practical and powerful approach to multiple testing. J R Statist Soc ser B 57, 289-300.
25. da Conceicao VN, Dyer WB, Gandhi K, Gupta P, SaksenaNK (2014) Genome-wide analysis of primary peripheral blood mononuclear cells fromHIV+ patients-pre-and post-HAART show immune activation and inflammation the main drivers of host gene expression. Mol Cell Ther 2, 11.
26. Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19, 185-193.
27. Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J (2004) Bioconductor: Open software development for computational biology and bioinformatics. Genome Biol 5, R80.
28. Saeed AI, Sharov V, White J, Li J, Liang W, Bhagabati N, Braisted J, Klapa M, Currier T, Thiagarajan M, Sturn A, Snuffin M, Rezantsev A, Popov D, Ryltsov A, Kostukovich E, Borisovsky I, Liu Z, Vinsavich A, Trush V, Quackenbush J (2003) TM4: A free, open-source system for microarray data management and analysis. BioTechniques 34, 374-378.
29. Matsuda H (2013) Voxel-based morphometry of brain MRI in normal aging and Alzheimer's disease. Aging Dis 4, 29-37.
30. Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38, 95-113.
31. Goto M, Abe O, Miyati T, Yoshikawa T, Hayashi N, Takao H, Inano S, Kabasawa H, Mori H, Kunimatsu A, Aoki S, Ino K, Iida K, Yano K, Ohtomo K (2011) Entorhinal cortex volume measured with 3T MRI is positively correlated with the Wechsler Memory Scale-Revised logical/verbal memory score for healthy subjects. Neuroradiology 53, 617-622.
32. Lonie JA, Tierney KM, Ebmeier KP (2009) Screening for mild cognitive impairment: A systematic review. Int J Geriatr Psychiatry 24, 902-915.
33. Grober E, Sanders AE, Hall C, Lipton RB (2010) Free and cued selective reminding identifies very mild dementia in primary care. Alzheimer Dis Assoc Disord 24, 284-290.
34. Derby CA, Burns LC, Wang C, Katz MJ, Zimmerman ME, L'italien G, Guo Z, Berman RM, Lipton RB (2013) Screening for predementia AD: Time-dependent operating characteristics of episodic memory tests. Neurology 80, 1307-1314.
35. Liu Y, Zeng X, Wang Z, Zhang N, Fan D, Yuan H (2015) Different post label delay cerebral blood flow measurements in patients with Alzheimer's disease using 3D arterial spin labeling. Magn Reson Imaging 33, 1019-1025.
36. Xekardaki A, Rodriguez C, Montandon M-L, Toma S, Tombeur E, Herrmann FR, Zekry D, Lovblad KO, Barkhof F, Giannakopoulos P, Haller S (2015) Arterial spin labeling may contribute to the prediction of cognitive deterioration in healthy elderly individuals. Radiology 274, 490-499.
37. Kim SG, Tsekos NV, Ashe J (1997) Multi-slice perfusionbased functional MRI using the FAIR technique: Comparison of CBF and BOLD effects. NMR Biomed 10, 191-196.
38. Li KL, Zhu X, Hylton N, Jahng GH, Weiner MW, Schuff N (2005) Four-phase single-capillary stepwise model for kinetics in arterial spin labeling MRI. Magn Reson Med 53, 511-518.
39. Son DO, Satsu H, Kiso Y, Totsuka M, Shimizu M (2008) Inhibitory effect of carnosine on interleukin-8 production in intestinal epithelial cells through translational regulation. Cytokine 42, 265-276.
40. Yao Y, Tsirka SE (2014) Monocyte chemoattractant protein-1 and the blood-brain barrier. Cell Mol Life Sci 71, 683-697.
41. Zimmerman ME, Pan JW, Hetherington HP, Katz MJ, Verghese J, Buschke H, Derby CA, Lipton RB (2008) Hippocampal neurochemistry, neuromorphometry, and verbal memory in nondemented older adults. Neurology 70, 1594-1600.
42. Travis SG, HuangY, Fujiwara E, Radomski A, Olsen F, Carter R, Seres P, Malykhin NV (2014) High field structural MRI reveals specific episodic memory correlates in the subfields of the hippocampus. Neuropsychologia 53, 233-245.
43. McDonald CR, Leyden KM, Hagler DJ, Kucukboyaci NE, Kemmotsu N, Tecoma ES, Iragui VJ (2014) White matter microstructure complements morphometry for predicting verbal memory in epilepsy. Cortex 58, 139-150.
44. Crush KG (1970) Carnosine and related substances in animal tissues. Comp Biochem Physiol 34, 3-30.
45. Suzuki T, Hirano T, Suyama M (1987) Free imidazole compounds in white and dark muscles of migratory marine fish. Comp Biochem Physiol B 87, 615-619.
46. Bell RD, Winkler EA, Singh I, Sagare AP, Deane R, Wu Z, HoltzmanDM,Betsholtz C, Armulik A, Sallstrom J, Berk BC, Zlokovic BV (2012) Apolipoprotein E controls cerebrovascular integrity via cyclophilin A. Nature 485, 512-516.
47. Montagne A, Barnes SR, Sweeney MD, Halliday MR, Sagare AP, Zhao Z, Toga AW, Jacobs RE, Liu CY, Amezcua L, Harrington MG, Chui HC, Law M, Zlokovic BV (2015) Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296-302.