Pleural hypercarbia after lung surgery is associated with persistent alveolopleural fistulae

Chest

Volumn 149, Issue 1, 2016, Pages 220-227

  Bharat, Ankit ^a   Graf, Nicole ^a   Mullen, Andrew ^a   Kanter, Jacob ^a   Andrei, Adin Cristian ^b   Sporn, Peter H S ^d   DeCamp, Malcolm M ^a   Sznajder, Jacob I ^c  

^a Div of Cardiac Electrophysiology   (United States)

^b Bluhm Cardiovascular Institute   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d JESSE BROWN VA MEDICAL CENTER   (United States)

Author keywords

Lung; Lung Injury; Thoracic Surgery

Indexed keywords

CARBON DIOXIDE; OXYGEN;

ADULT; ALVEOLOPLEURAL FISTULA; ARTICLE; ASPIRATION, PUNCTURE AND SUCTION; DISEASE ASSOCIATION; EXTRAPLEURAL SUCTION; FEMALE; GAS ANALYSIS; HUMAN; HYPERCAPNIA; LUNG ALVEOLUS HYPOVENTILATION; LUNG LOBECTOMY; LUNG RESECTION; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; OXYGEN THERAPY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY TRACT FISTULA; WEDGE RESECTION; ADVERSE EFFECTS; AGED; LUNG ALVEOLUS; PLEURAL DISEASES; SUCTION;

ADULT; AGED; FEMALE; HUMANS; HYPERCAPNIA; MALE; MIDDLE AGED; OXYGEN INHALATION THERAPY; PLEURAL DISEASES; PNEUMONECTOMY; PROSPECTIVE STUDIES; PULMONARY ALVEOLI; RESPIRATORY TRACT FISTULA; SUCTION;

EID: 84954146985     PISSN: 00123692     EISSN: 19313543     Source Type: Journal    
DOI: 10.1378/chest.15-1591     Document Type: Article

References (30)

1. Abolhoda A, Liu D, Brooks A, Burt M. Prolonged air leak following radical upper lobectomy: an analysis of incidence and possible risk factors. Chest. 1998;113(6): 1507-1510.
2. Okereke I, Murthy SC, Alster JM, Blackstone EH, Rice TW. Characterization and importance of air leak after lobectomy. Ann Thorac Surg. 2005;79(4):1167-1173.
3. Stephan F, Boucheseiche S, Hollande J, et al. Pulmonary complications following lung resection: a comprehensive analysis of incidence and possible risk factors. Chest. 2000;118(5):1263-1270.
4. DeCamp MM, Blackstone EH, Naunheim KS, et al. Patient and surgical factors influencing air leak after lung volume reduction surgery: lessons learned from the National Emphysema Treatment Trial. Ann Thorac Surg. 2006;82(1): 197-206; discussion 206-197.
5. Cerfolio RJ, Tummala RP, Holman WL, et al. A prospective algorithm for the management of air leaks after pulmonary resection. Ann Thorac Surg. 1998;66(5): 1726-1731.
6. Varela G, Jimenez MF, Novoa N, Aranda JL. Estimating hospital costs attributable to prolonged air leak in pulmonary lobectomy. Eur J Cardiothorac Surg. 2005;27(2):329-333.
7. Irshad K, Feldman LS, Chu VF, Dorval JF, Baslaim G, Morin JE. Causes of increased length of hospitalization on a general thoracic surgery service: a prospective observational study. Can J Surg. 2002; 45(4):264-268.
8. Ciccone AM, Meyers BF, Guthrie TJ, et al. Long-Term outcome of bilateral lung volume reduction in 250 consecutive patients with emphysema. J Thorac Cardiovasc Surg. 2003;125(3):513-525.
9. Gomez-Caro A, Calvo MJ, Lanzas JT, Chau R, Cascales P, Parrilla P. The approach of fused fissures with fissureless technique decreases the incidence of persistent air leak after lobectomy. Eur J Cardiothorac Surg. 2007;31(2):203-208.
10. Keller CA. Lasers, staples, bovine pericardium, talc, glue and.suction cylinders? Tools of the trade to avoid air leaks in lung volume reduction surgery. Chest. 2004;125(2):361-363.
11. Barkauskas CE, Cronce MJ, Rackley CR, et al. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest. 2013;123(7): 3025-3036.
12. Ridge KM, Olivera WG, Saldias F, et al. Alveolar type 1 cells express the alpha2 Na,K-ATPase, which contributes to lung liquid clearance. Circ Res. 2003;92(4): 453-460.
13. Vadasz I, Hubmayr RD, Nin N, Sporn PH, Sznajder JI. Hypercapnia: a nonpermissive environment for the lung. Am J Respir Cell Mol Biol. 2012;46(4):417-421.
14. Vohwinkel CU, Lecuona E, Sun H, et al. Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation. J Biol Chem. 2011;286(43):37067-37076.
15. Sen CK. Wound healing essentials: let there be oxygen. Would Repair Regen. 2009;17(1):1-18.
16. Sano H, Ichioka S, Sekiya N. Influence of oxygen on wound healing dynamics: assessment in a novel wound mouse model under a variable oxygen environment. PloS One. 2012;7(11):e50212.
17. Attard JA, Raval MJ, Martin GR, et al. The effects of systemic hypoxia on colon anastomotic healing: an animal model. Dis Colon Rectum. 2005;48(7):1460-1470.
18. Balasubramaniam V, Tang JR, Maxey A, Plopper CG, Abman SH. Mild hypoxia impairs alveolarization in the endothelial nitric oxide synthase-deficient mouse. Am J Physiol Lung Cell Mol Physiol. 2003; 284(6):L964-L971.
19. Cerfolio RJ, Bryant AS, Thurber JS, Bass CS, Lell WA, Bartolucci AA. Intraoperative solumedrol helps prevent postpneumonectomy pulmonary edema. Ann Thorac Surg. 2003;76(4):1029-1033; discussion 1033-1025.
20. Cerfolio RJ, Bryant AS. The management of chest tubes after pulmonary resection. Thor Surg Clin. 2010;20(3):399-405.
21. Singhal S, Ferraris VA, Bridges CR, et al. Management of alveolar air leaks after pulmonary resection. Ann Thorac Surg. 2010;89(4):1327-1335.
22. Doerr CH, Gajic O, Berrios JC, et al. Hypercapnic acidosis impairs plasma membrane wound resealing in ventilatorinjured lungs. Am J Respir Crit Care Med. 2005;171(12):1371-1377.
23. Cummins EP, Selfridge AC, Sporn PH, Sznajder JI, Taylor CT. Carbon dioxidesensing in organisms and its implications for human disease. Cell Mol Life Sci. 2014; 71(5):831-845.
24. Berthiaume Y, Lesur O, Dagenais A. Treatment of adult respiratory distress syndrome: plea for rescue therapy of the alveolar epithelium. Thorax. 1999;54(2): 150-160.
25. Wang N, Gates KL, Trejo H, et al. Elevated CO2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. FASEB J. 2010;24(7): 2178-2190.
26. Helenius IT, Krupinski T, Turnbull DW, et al. Elevated CO2 suppresses specific Drosophila innate immune responses and resistance to bacterial infection. Proc Natl Acad Sci U S A. 2009;106(44): 18710-18715.
27. Seok Y, Cho S, Lee JY, Yang HC, Kim K, Jheon S. The effect of postoperative change in bronchial angle on postoperative pulmonary function after upper lobectomy in lung cancer patients. Interact Cardiovasc Thorac Surg. 2014;18(2):183-188.
28. Ueda K, Tanaka T, Hayashi M, Tanaka N, Li TS, Hamano K. Clinical ramifications of bronchial kink after upper lobectomy. Ann Thorac Surg. 2012;93(1):259-265.
29. Ueda K, Tanaka T, Hayashi M, et al. Compensation of pulmonary function after upper lobectomy versus lower lobectomy. J Thorac Cardiovasc Surg. 2011;142(4):762-767.
30. Qiu T, Shen Y, Wang MZ, et al. External suction versus water seal after selective pulmonary resection for lung neoplasm: a systematic review. PloS One. 2013;8(7): e68087.