Heavy ethanol consumption aggravates the ischemic cerebral injury by inhibiting ALDH2

International Journal of Stroke

Volumn 10, Issue 8, 2015, Pages 1261-1269

  Wang, Wei ^a,b   Lin, Li Li ^a,c   Guo, Jin Min ^a,d   Cheng, Yan Qiong ^a,e   Qian, Jiao ^a,e   Mehta, Jawahar L ^f   Su, Ding Feng ^a   Luan, Ping ^g   Liu, Ai Jun ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b Hangzhou Sanatorium of PLA ^*  (China)

^c Wuxi Higher Health Vocational Technology School   (China)

^d JINAN MILITARY GENERAL HOSPITAL   (China)

^e SECOND MILITARY MEDICAL UNIVERSITY   (China)

^f CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^g Shenzhen University School of Medicine   (China)

Author keywords

4 HNE; acetaldehyde; ALDH2; heavy ethanol consumption; ischemic stroke; risk factor

Indexed keywords

4 HYDROXYNONENAL; ACETALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2; MALONALDEHYDE; ALCOHOL; ALDEHYDE DEHYDROGENASE; ALDH2 PROTEIN, RAT; CENTRAL DEPRESSANT AGENT; GLUCOSE; MITOCHONDRIAL PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONTROLLED STUDY; ENZYME INHIBITION; ISOELECTRIC POINT; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NONHUMAN; PATHOGENESIS; PC12 CELL LINE; PRIORITY JOURNAL; RAT; STROKE PRONE SPONTANEOUSLY HYPERTENSIVE RAT; SURVIVAL TIME; ANIMAL; BRAIN; CELL HYPOXIA; CEREBRAL ARTERY DISEASE; CEREBROVASCULAR ACCIDENT; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; ENZYMOLOGY; GENETICS; METABOLISM; NERVE CELL; PATHOLOGY; PHYSIOLOGY; RANDOMIZATION; SPONTANEOUSLY HYPERTENSIVE RAT; SPRAGUE DAWLEY RAT;

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE, MITOCHONDRIAL; ANIMALS; BRAIN; BRAIN ISCHEMIA; CELL HYPOXIA; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DISEASE MODELS, ANIMAL; ETHANOL; GLUCOSE; INFARCTION, MIDDLE CEREBRAL ARTERY; MALE; MITOCHONDRIAL PROTEINS; NEURONS; PC12 CELLS; RANDOM ALLOCATION; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; STROKE;

EID: 84954128241     PISSN: 17474930     EISSN: 17474949     Source Type: Journal    
DOI: 10.1111/ijs.12560     Document Type: Article

References (32)

1. Donnan GA, Fisher M, Macleod M, Davis SM,. Stroke. Lancet 2008; 371:1612-23.
2. Jauch EC, Cucchiara B, Adeoye O,. Part 11: adult stroke: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care. Circulation 2010; 122(18 Suppl. 3):S818-28.
3. Luo M, Li JX, Sun XS,. The single nucleotide polymorphism rs2208454 confers an increased risk for ischemic stroke: a case-control study. CNS Neurosci Ther 2014; 20:893-7.
4. Patra J, Taylor B, Irving H,. Alcohol consumption and the risk of morbidity and mortality for different stroke types-a systematic review and meta-analysis. BMC Public Health 2010; 10:258.
5. Caicoya M, Rodriguez T, Corrales C, Cuello R, Lasheras C,. Alcohol and stroke: a community case-control study in Asturias, Spain. J Clin Epidemiol 1999; 52:677-84.
6. Gill JS, Zezulka AV, Shipley MJ, Gill SK, Beevers DG,. Stroke and alcohol consumption. N Engl J Med 1986; 315:1041-6.
7. Jimenez M, Chiuve SE, Glynn RJ,. Alcohol consumption and risk of stroke in women. Stroke 2012; 43:939-45.
8. Mostofsky EBM, Schlaug G, Mukamal KJ, Rosamond WD, Mittleman MA,. Alcohol and acute ischemic stroke onset: the stroke onset study. Stroke 2010; 41:1845-9.
9. Zhao H, Mayhan WG, Arrick DM, Xiong W, Sun H,. Dose-related influence of chronic alcohol consumption on cerebral ischemia/reperfusion injury. Alcohol Clin Exp Res 2011; 35:1265-9.
10. Kanbe H, Kamijo Y, Nakajima T,. Chronic ethanol consumption decreases serum sulfatide levels by suppressing hepatic cerebroside sulfotransferase expression in mice. Arch Toxicol 2014; 88:367-79.
11. Lagranha CJ, Deschamps A, Aponte A, Steenbergen C, Murphy E,. Sex differences in the phosphorylation of mitochondrial proteins result in reduced production of reactive oxygen species and cardioprotection in females. Circ Res 2010; 106:1681-91.
12. Guo JMLA, Zang P, Dong WZ,. ALDH2 protects against stroke by clearing 4-HNE. Cell Res 2013; 23:915-30.
13. Hintz KK, Relling DP, Saari JT,. Cardiac overexpression of alcohol dehydrogenase exacerbates cardiac contractile dysfunction, lipid per-oxidation, and protein damage after chronic ethanol ingestion. Alcohol Clin Exp Res 2003; 27:1090-8.
14. Ma H, Guo R, Yu L, Zhang Y, Ren J,. Aldehyde dehydrogenase 2 (ALDH2) rescues myocardial ischaemia/reperfusion injury: role of autophagy paradox and toxic aldehyde. Eur Heart J 2011; 32:1025-38.
15. Raza H, John A,. 4-hydroxynonenal induces mitochondrial oxidative stress, apoptosis and expression of glutathione S-transferase A4-4 and cytochrome P450 2E1 in PC12 cells. Toxicol Appl Pharmacol 2006; 216:309-18.
16. Yuan Q, Hong S, Han S,. Preconditioning with physiological levels of ethanol protect kidney against ischemia/reperfusion injury by modulating oxidative stress. PLoS ONE 2011; 6:e25811.
17. Chaudhary P, Sharma R, Sharma A,. Mechanisms of 4-hydroxy-2-nonenal induced pro-and anti-apoptotic signaling. Biochemistry 2010; 49:6263-75.
18. Jones AW, Mardh G, Anggard E,. Determination of endogenous ethanol in blood and breath by gas chromatography-mass spectrometry. Pharmacol Biochem Behav 1983; 18(Suppl. 1):267-72.
19. Pontes H, Guedes de Pinho P, Casal S,. GC determination of acetone, acetaldehyde, ethanol, and methanol in biological matrices and cell culture. J Chromatogr Sci 2009; 47:272-8.
20. Zhao B, Wang HB, Lu YJ, Hu JW, Bao L, Zhang X,. Transport of receptors, receptor signaling complexes and ion channels via neuropeptide-secretory vesicles. Cell Res 2011; 21:741-53.
21. Shih AY, Blinder P, Tsai PS,. The smallest stroke: occlusion of one penetrating vessel leads to infarction and a cognitive deficit. Nat Neurosci 2013; 16:55-63.
22. Liu XJ, Wu WT, Wu WH,. A minority subpopulation of CD133(+)/EGFRvIII(+)/EGFR(-) cells acquires stemness and contributes to gefitinib resistance. CNS Neurosci Ther 2013; 19:494-502.
23. Zhao ZY, Luan P, Huang SX,. Edaravone protects HT22 neurons from H2O2-induced apoptosis by inhibiting the MAPK signaling pathway. CNS Neurosci Ther 2013; 19:163-9.
24. Zhou HG, Liu L, Zhang Y,. Glutathione prevents free fatty acids-induced oxidative stress and apoptosis in human brain vascular endothelial cells through Akt pathway. CNS Neurosci Ther 2013; 19:252-61.
25. Zhang Y, Choksi S, Chen K, Pobezinskaya Y, Linnoila I, Liu ZG,. ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages. Cell Res 2013; 23:898-914.
26. Yan T, Venkat P, Ye X,. HUCBCs increase angiopoietin 1 and induce neurorestorative effects after stroke in T1DM rats. CNS Neurosci Ther 2014; 20:935-44.
27. Niwa M, Kamiya A, Murai R,. Knockdown of DISC1 by in utero gene transfer disturbs postnatal dopaminergic maturation in the frontal cortex and leads to adult behavioral deficits. Neuron 2010; 65:480-9.
28. Ren J, Babcock SA, Li Q, Huff AF, Li SY, Doser TA,. Aldehyde dehydrogenase-2 transgene ameliorates chronic alcohol ingestion-induced apoptosis in cerebral cortex. Toxicol Lett 2009; 187:149-56.
29. Yao CT, Cheng CA, Wang HK,. The role of ALDH2 and ADH1B polymorphism in alcohol consumption and stroke in Han Chinese. Hum Genomics 2011; 5:569-76.
30. Quertemont E,. Genetic polymorphism in ethanol metabolism: acetaldehyde contribution to alcohol abuse and alcoholism. Mol Psychiatry 2004; 9:570-81.
31. Petersen DR, Doorn JA,. Reactions of 4-hydroxynonenal with proteins and cellular targets. Free Radic Biol Med 2004; 37:937-45.
32. Esterbauer H, Schaur RJ, Zollner H,. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 1991; 11:81-128.