Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation

Journal of Bone and Mineral Research

Volumn 30, Issue 12, 2015, Pages 2262-2272

  Amano, Katsuhiko ^a   Densmore, Michael J ^a   Lanske, Beate ^a  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

BONE DYSPLASIA; BONE FORMATION; GROWTH PLATE; INDIAN HEDGEHOG; LIMB MESENCHYME

Indexed keywords

CATION; OSTEOCALCIN; SONIC HEDGEHOG PROTEIN; HOMEODOMAIN PROTEIN; IHH PROTEIN, MOUSE; PRRX1 PROTEIN, MOUSE; RNA;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE DYSPLASIA; BONE REMODELING; BONE STRUCTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; CORTICAL BONE; FEMALE; GENE EXPRESSION; GROWTH PLATE; LIMB; LIMB DISEASE; MALE; MESENCHYME; MORPHOMETRICS; MOUSE; MUTANT; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST; OSTEOCLAST ACTIVITY; OSTEOLYSIS; PERINATAL PERIOD; PHENOTYPE; PRENATAL DEVELOPMENT; PROTEIN EXPRESSION; PROTEIN STRUCTURE; ANIMAL; BONE; CELL PROLIFERATION; CHONDROCYTE; CYTOLOGY; EPIPHYSIS PLATE; GENE DELETION; GENETICS; GENOTYPE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; MESENCHYMAL STROMA CELL; MESODERM; METABOLISM; MUTATION; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE;

ANIMALS; BONE AND BONES; CELL DIFFERENTIATION; CELL PROLIFERATION; CHONDROCYTES; EXTREMITIES; FEMALE; GENE DELETION; GENOTYPE; GROWTH PLATE; HEDGEHOG PROTEINS; HOMEODOMAIN PROTEINS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; KIDNEY; MALE; MESENCHYMAL STROMAL CELLS; MESODERM; MICE; MICE, TRANSGENIC; MUTATION; OSTEOBLASTS; OSTEOCALCIN; OSTEOCLASTS; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; RNA;

EID: 84954077113     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.2582     Document Type: Article

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