Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method

Oncology Reports

Volumn 35, Issue 1, 2016, Pages 211-218

  Mi, Ruifang ^a,b   Pan, Chunxiao ^a,b   Zhou, Yiqiang ^a   Liu, Yuanbo ^a   Jin, Guishan ^a   Liu, Fusheng ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Fusion method; Melanoma multinucleated giant cells; Metastasis; TUBB2B gene

Indexed keywords

BETA TUBULIN; DNA; PHYTOHEMAGGLUTININ; TUBB2B PROTEIN, MOUSE; TUBULIN;

AKT3 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL AGGLUTINATION; CELL FUSION; CELL PROLIFERATION; CONTROLLED STUDY; EX VIVO STUDY; FEMALE; GENE; GENE EXPRESSION; GIANT CELL; IN VITRO STUDY; LUNG METASTASIS; MELANOMA; METASTASIS; METASTASIS POTENTIAL; MOUSE; NONHUMAN; PIK3R1 GENE; PRIORITY JOURNAL; RPS6KA1 GENE; TUBB2A PS2 GENE; TUBB2B GENE; TUBB6 GENE; UPREGULATION; ANIMAL; DNA MICROARRAY; EXPERIMENTAL MELANOMA; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; PROCEDURES; TUMOR CELL LINE;

ANIMALS; CELL FUSION; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GIANT CELLS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; NEOPLASM METASTASIS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; TUBULIN; UP-REGULATION;

EID: 84954044430     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.4376     Document Type: Article

References (30)

1. de Santis CE, Lin CC, Mariotto AB, Siegel RL, Stein KD, Kramer JL, Alteri R, Robbins AS and Jemal A: Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin 64: 252-271, 2014.
2. Damsky WE, Theodosakis N and Bosenberg M: Melanoma metastasis: New concepts and evolving paradigms. Oncogene 33: 2413-2422, 2014.
3. Abdalla F, Boder J, Markus R, Hashmi H, Buhmeida A and Collan Y: Correlation of nuclear morphometry of breast cancer in histological sections with clinicopathological features and prognosis. Anticancer Res 29: 1771-1776, 2009.
4. Rajagopalan H and Lengauer C: Aneuploidy and cancer. Nature 432: 338-341, 2004.
5. Mossbacher U, Knollmayer S, Binder M, Steiner A, Wolff K and Pehamberger H: Increased nuclear volume in metastasizing 'thick' melanomas. J Invest Dermatol 106: 437-440, 1996.
6. Pawelek JM and Chakraborty AK: Fusion of tumour cells with bone marrow-derived cells: A unifying explanation for metastasis. Nat Rev Cancer 8: 377-386, 2008.
7. Fidler IJ: The role of the organ microenvironment in brain metastasis. Semin Cancer Biol 21: 107-112, 2011.
8. Langley RR and Fidler IJ: The seed and soil hypothesis revisited - the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer 128: 2527-2535, 2011.
9. Nguyen DX, Bos PD and Massagué J: Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284, 2009.
10. Nguyen DX and Massagué J: Genetic determinants of cancer metastasis. Nat Rev Genet 8: 341-352, 2007.
11. Gupta GP, Minn AJ, Kang Y, Siegel PM, Serganova I, Cordón-Cardo C, Olshen AB, Gerald WL and Massagué J: Identifying site-specific metastasis genes and functions. Cold Spring Harb Symp Quant Biol 70: 149-158, 2005.
12. Fidler IJ: The pathogenesis of cancer metastasis: The 'seed and soil' hypothesis revisited. Nat Rev Cancer 3: 453-458, 2003.
13. Lentz BR: PEG as a tool to gain insight into membrane fusion. Eur Biophys J 36: 315-326, 2007.
14. Kandušer M and Ušaj M: Cell electrofusion: Past and future perspectives for antibody production and cancer cell vaccines. Expert Opin Drug Deliv 11: 1885-1898, 2014.
15. Veselý P, Entlicher G and Kocourek J: Pea phytohemagglutinin selective agglutination of tumour cells. Experientia 28: 1085-1086, 1972.
16. Russo G, Zegar C and Giordano A: Advantages and limitations of microarray technology in human cancer. Oncogene 22: 6497-6507, 2003.
17. Dalma-Weiszhausz DD, Warrington J, Tanimoto EY and Miyada CG: The affymetrix GeneChip platform: An overview. Methods Enzymol 410: 3-28, 2006.
18. Kutner RH, Zhang XY and Reiser J: Production, concentration and titration of pseudotyped HIV-1-based lentiviral vectors. Nat Protoc 4: 495-505, 2009.
19. Fidler IJ and Nicolson GL: Organ selectivity for implantation survival and growth of b16 melanoma variant tumor lines. J Natl Cancer Inst 57: 1199-1202, 1976.
20. Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S and Grompe M: Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422: 897-901, 2003.
21. Chakraborty AK, Sodi S, Rachkovsky M, Kolesnikova N, Platt JT, Bolognia JL and Pawelek JM: A spontaneous murine melanoma lung metastasis comprised of host x tumor hybrids. Cancer Res 60: 2512-2519, 2000.
22. Duelli D and Lazebnik Y: Cell-to-cell fusion as a link between viruses and cancer. Nat Rev Cancer 7: 968-976, 2007.
23. Duelli D and Lazebnik Y: Cell fusion: A hidden enemy? Cancer Cell 3: 445-448, 2003.
24. Harris H: The analysis of malignancy by cell fusion: The position in 1988. Cancer Res 48: 3302-3306, 1988.
25. Green DR and Kroemer G: Cytoplasmic functions of the tumour suppressor p53. Nature 458: 1127-1130, 2009.
26. Babchia N, Calipel A, Mouriaux F, Faussat AM and Mascarelli F: The PI3K/Akt and mToR/P70S6K signaling pathways in human uveal melanoma cells: Interaction with b-Raf/ERK. Invest Ophthalmol Vis Sci 51: 421-429, 2010.
27. Cantley LC: The phosphoinositide 3-kinase pathway. Science 296: 1655-1657, 2002.
28. Wong KK, Engelman JA and Cantley LC: Targeting the PI3K signaling pathway in cancer. Curr Opin Genet Dev 20: 87-90, 2010.
29. Jattani R, Patel U, Kerman B and Myat MM: Deficiency screen identifies a novel role for beta 2 tubulin in salivary gland and myoblast migration in the Drosophila embryo. Dev Dyn 238: 853-863, 2009.
30. Jaglin XH, Poirier K, Saillour Y, Buhler E, Tian G, Bahi-Buisson N, Fallet-Bianco C, Phandinh-Tuy F, Kong XP, Bomont P, et al: Mutations in the beta-tubulin gene TUBB2B result in asymmetrical polymicrogyria. Nat Genet 41: 746-752, 2009.