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Volumn 16, Issue 1, 2016, Pages

Lgr5 expression is a valuable prognostic factor for colorectal cancer: Evidence from a meta-analysis

Author keywords

Clinical pathological differences; Colorectal cancer; Lgr5; Meta analysis; Prognostic value

Indexed keywords

BIOLOGICAL MARKER; FLUOROURACIL; G PROTEIN COUPLED RECEPTOR; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; UNCLASSIFIED DRUG; LGR5 PROTEIN, HUMAN; TUMOR MARKER;

EID: 84953881173     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1986-2     Document Type: Article
Times cited : (28)

References (34)
  • 1
    • 84899438176 scopus 로고    scopus 로고
    • Colorectal cancer statistics, 2014
    • Siegel R, Desantis C, Jemal A. Colorectal cancer statistics, 2014. CA Cancer J Clin. 2014;64(2):104-17.
    • (2014) CA Cancer J Clin , vol.64 , Issue.2 , pp. 104-117
    • Siegel, R.1    Desantis, C.2    Jemal, A.3
  • 2
    • 72449176846 scopus 로고    scopus 로고
    • Molecular origins of cancer: Molecular basis of colorectal cancer
    • Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med. 2009;361(25):2449-60.
    • (2009) N Engl J Med , vol.361 , Issue.25 , pp. 2449-2460
    • Markowitz, S.D.1    Bertagnolli, M.M.2
  • 3
    • 0035804647 scopus 로고    scopus 로고
    • Impact of patient and provider characteristics on the treatment and outcomes of colorectal cancer
    • Hodgson DC, Fuchs CS, Ayanian JZ. Impact of patient and provider characteristics on the treatment and outcomes of colorectal cancer. J Natl Cancer Inst. 2001;93(7):501-15.
    • (2001) J Natl Cancer Inst , vol.93 , Issue.7 , pp. 501-515
    • Hodgson, D.C.1    Fuchs, C.S.2    Ayanian, J.Z.3
  • 4
    • 38849086811 scopus 로고    scopus 로고
    • Benson 3rd AB. Adjuvant therapy for colon cancer
    • Aranha O. Benson 3rd AB. Adjuvant therapy for colon cancer. Curr Gastroenterol Rep. 2007;9(5):415-21.
    • (2007) Curr Gastroenterol Rep , vol.9 , Issue.5 , pp. 415-421
    • Aranha, O.1
  • 5
  • 6
    • 34848899578 scopus 로고    scopus 로고
    • Chemotherapy and cancer stem cells
    • Rich JN, Bao S. Chemotherapy and cancer stem cells. Cell Stem Cell. 2007;1(4):353-5.
    • (2007) Cell Stem Cell , vol.1 , Issue.4 , pp. 353-355
    • Rich, J.N.1    Bao, S.2
  • 7
    • 70549113666 scopus 로고    scopus 로고
    • Apoptosis signaling in cancer stem cells
    • Fulda S, Pervaiz S. Apoptosis signaling in cancer stem cells. Int J Biochem Cell Biol. 2010;42(1):31-8.
    • (2010) Int J Biochem Cell Biol , vol.42 , Issue.1 , pp. 31-38
    • Fulda, S.1    Pervaiz, S.2
  • 8
    • 84865973290 scopus 로고    scopus 로고
    • Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients
    • Coco C, Zannoni GF, Caredda E, Sioletic S, Boninsegna A, Migaldi M, et al. Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients. J Exp Clin Cancer Res. 2012;31:71.
    • (2012) J Exp Clin Cancer Res , vol.31 , pp. 71
    • Coco, C.1    Zannoni, G.F.2    Caredda, E.3    Sioletic, S.4    Boninsegna, A.5    Migaldi, M.6
  • 9
    • 84864780648 scopus 로고    scopus 로고
    • CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients
    • Zhang SS, Han ZP, Jing YY, Tao SF, Li TJ, Wang H, et al. CD133(+)CXCR4(+) colon cancer cells exhibit metastatic potential and predict poor prognosis of patients. BMC Med. 2012;10:85.
    • (2012) BMC Med , vol.10 , pp. 85
    • Zhang, S.S.1    Han, Z.P.2    Jing, Y.Y.3    Tao, S.F.4    Li, T.J.5    Wang, H.6
  • 10
    • 33846100356 scopus 로고    scopus 로고
    • A human colon cancer cell capable of initiating tumour growth in immunodeficient mice
    • O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445(7123):106-10.
    • (2007) Nature , vol.445 , Issue.7123 , pp. 106-110
    • O'Brien, C.A.1    Pollett, A.2    Gallinger, S.3    Dick, J.E.4
  • 12
    • 45749102020 scopus 로고    scopus 로고
    • CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors
    • Shmelkov SV, Butler JM, Hooper AT, Hormigo A, Kushner J, Milde T, et al. CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J Clin Invest. 2008;118(6):2111-20.
    • (2008) J Clin Invest , vol.118 , Issue.6 , pp. 2111-2120
    • Shmelkov, S.V.1    Butler, J.M.2    Hooper, A.T.3    Hormigo, A.4    Kushner, J.5    Milde, T.6
  • 13
    • 56749091913 scopus 로고    scopus 로고
    • Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue
    • Becker L, Huang Q, Mashimo H. Immunostaining of Lgr5, an intestinal stem cell marker, in normal and premalignant human gastrointestinal tissue. Scientific World Journal. 2008;8:1168-76.
    • (2008) Scientific World Journal , vol.8 , pp. 1168-1176
    • Becker, L.1    Huang, Q.2    Mashimo, H.3
  • 14
    • 84891824337 scopus 로고    scopus 로고
    • Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer
    • Hsu HC, Liu YS, Tseng KC, Hsu CL, Liang Y, Yang TS, et al. Overexpression of Lgr5 correlates with resistance to 5-FU-based chemotherapy in colorectal cancer. Int J Colorectal Dis. 2013;28(11):1535-46.
    • (2013) Int J Colorectal Dis , vol.28 , Issue.11 , pp. 1535-1546
    • Hsu, H.C.1    Liu, Y.S.2    Tseng, K.C.3    Hsu, C.L.4    Liang, Y.5    Yang, T.S.6
  • 15
    • 0037369658 scopus 로고    scopus 로고
    • Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations
    • Yamamoto Y, Sakamoto M, Fujii G, Tsuiji H, Kenetaka K, Asaka M, et al. Overexpression of orphan G-protein-coupled receptor, Gpr49, in human hepatocellular carcinomas with beta-catenin mutations. Hepatology. 2003;37(3):528-33.
    • (2003) Hepatology , vol.37 , Issue.3 , pp. 528-533
    • Yamamoto, Y.1    Sakamoto, M.2    Fujii, G.3    Tsuiji, H.4    Kenetaka, K.5    Asaka, M.6
  • 16
    • 33646419556 scopus 로고    scopus 로고
    • Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors
    • McClanahan T, Koseoglu S, Smith K, Grein J, Gustafson E, Black S, et al. Identification of overexpression of orphan G protein-coupled receptor GPR49 in human colon and ovarian primary tumors. Cancer Biol Ther. 2006;5(4):419-26.
    • (2006) Cancer Biol Ther , vol.5 , Issue.4 , pp. 419-426
    • McClanahan, T.1    Koseoglu, S.2    Smith, K.3    Grein, J.4    Gustafson, E.5    Black, S.6
  • 17
    • 77954652500 scopus 로고    scopus 로고
    • Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer
    • Uchida H, Yamazaki K, Fukuma M, Yamada T, Hayashida T, Hasegawa H, et al. Overexpression of leucine-rich repeat-containing G protein-coupled receptor 5 in colorectal cancer. Cancer Sci. 2010;101(7):1731-7.
    • (2010) Cancer Sci , vol.101 , Issue.7 , pp. 1731-1737
    • Uchida, H.1    Yamazaki, K.2    Fukuma, M.3    Yamada, T.4    Hayashida, T.5    Hasegawa, H.6
  • 18
    • 51349161304 scopus 로고    scopus 로고
    • G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
    • Tanese K, Fukuma M, Yamada T, Mori T, Yoshikawa T, Watanabe W, et al. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol. 2008;173(3):835-43.
    • (2008) Am J Pathol , vol.173 , Issue.3 , pp. 835-843
    • Tanese, K.1    Fukuma, M.2    Yamada, T.3    Mori, T.4    Yoshikawa, T.5    Watanabe, W.6
  • 19
    • 84878768150 scopus 로고    scopus 로고
    • In situ validation of an intestinal stem cell signature in colorectal cancer
    • Ziskin JL, Dunlap D, Yaylaoglu M, Fodor IK, Forrest WF, Patel R, et al. In situ validation of an intestinal stem cell signature in colorectal cancer. Gut. 2013;62(7):1012-23.
    • (2013) Gut , vol.62 , Issue.7 , pp. 1012-1023
    • Ziskin, J.L.1    Dunlap, D.2    Yaylaoglu, M.3    Fodor, I.K.4    Forrest, W.F.5    Patel, R.6
  • 20
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L. Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med. 1998;17(24):2815-34.
    • (1998) Stat Med , vol.17 , Issue.24 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 21
    • 0021909115 scopus 로고
    • Beta blockade during and after myocardial infarction: an overview of the randomized trials
    • Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis. 1985;27(5):335-71.
    • (1985) Prog Cardiovasc Dis , vol.27 , Issue.5 , pp. 335-371
    • Yusuf, S.1    Peto, R.2    Lewis, J.3    Collins, R.4    Sleight, P.5
  • 22
    • 0041876133 scopus 로고    scopus 로고
    • Measuring inconsistency in meta-analyses
    • Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557-60.
    • (2003) BMJ , vol.327 , Issue.7414 , pp. 557-560
    • Higgins, J.P.1    Thompson, S.G.2    Deeks, J.J.3    Altman, D.G.4
  • 23
    • 84868683556 scopus 로고    scopus 로고
    • Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival
    • Wu XS, Xi HQ, Chen L. Lgr5 is a potential marker of colorectal carcinoma stem cells that correlates with patient survival. World J Surg Oncol. 2012;10:244.
    • (2012) World J Surg Oncol , vol.10 , pp. 244
    • Wu, X.S.1    Xi, H.Q.2    Chen, L.3
  • 24
    • 84867777294 scopus 로고    scopus 로고
    • Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy
    • Saigusa S, Inoue Y, Tanaka K, Toiyama Y, Matsushita K, Kawamura M, et al. Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy. Int J Oncol. 2012;41(5):1643-52.
    • (2012) Int J Oncol , vol.41 , Issue.5 , pp. 1643-1652
    • Saigusa, S.1    Inoue, Y.2    Tanaka, K.3    Toiyama, Y.4    Matsushita, K.5    Kawamura, M.6
  • 25
    • 84860162754 scopus 로고    scopus 로고
    • Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer
    • Valladares-Ayerbes M, Blanco-Calvo M, Reboredo M, Lorenzo-Patino MJ, Iglesias-Diaz P, Haz M, et al. Evaluation of the Adenocarcinoma-Associated Gene AGR2 and the Intestinal Stem Cell Marker LGR5 as Biomarkers in Colorectal Cancer. Int J Mol Sci. 2012;13(4):4367-87.
    • (2012) Int J Mol Sci , vol.13 , Issue.4 , pp. 4367-4387
    • Valladares-Ayerbes, M.1    Blanco-Calvo, M.2    Reboredo, M.3    Lorenzo-Patino, M.J.4    Iglesias-Diaz, P.5    Haz, M.6
  • 27
    • 79851502476 scopus 로고    scopus 로고
    • Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis
    • Takeda K, Kinoshita I, Shimizu Y, Matsuno Y, Shichinohe T, Dosaka-Akita H. Expression of LGR5, an intestinal stem cell marker, during each stage of colorectal tumorigenesis. Anticancer Res. 2011;31(1):263-70.
    • (2011) Anticancer Res , vol.31 , Issue.1 , pp. 263-270
    • Takeda, K.1    Kinoshita, I.2    Shimizu, Y.3    Matsuno, Y.4    Shichinohe, T.5    Dosaka-Akita, H.6
  • 29
    • 84969294430 scopus 로고    scopus 로고
    • Detection of cancer stem marker, Lgr5, in colorectal cancer
    • WG Bao YC. Detection of cancer stem marker, Lgr5, in colorectal cancer. Lin Chuang Jian Yan Za Zhi. 2012;30(9):691-3.
    • (2012) Lin Chuang Jian Yan Za Zhi , vol.30 , Issue.9 , pp. 691-693
    • WG Bao, Y.C.1
  • 30
    • 84899521652 scopus 로고    scopus 로고
    • Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer
    • Gao FJ, Chen JY, Wu HY, Shi J, Chen M, Fan XS, et al. Lgr5 over-expression is positively related to the tumor progression and HER2 expression in stage pTNM IV colorectal cancer. Int J Clin Exp Pathol. 2014;7(4):1572-9.
    • (2014) Int J Clin Exp Pathol , vol.7 , Issue.4 , pp. 1572-1579
    • Gao, F.J.1    Chen, J.Y.2    Wu, H.Y.3    Shi, J.4    Chen, M.5    Fan, X.S.6
  • 31
    • 84905080747 scopus 로고    scopus 로고
    • Expression of Lgr5, a marker of intestinal stem cells, in colorectal cancer and its clinicopathological significance
    • He S, Zhou H, Zhu X, Hu S, Fei M, Wan D, et al. Expression of Lgr5, a marker of intestinal stem cells, in colorectal cancer and its clinicopathological significance. Biomed Pharmacother. 2014;68(5):507-13.
    • (2014) Biomed Pharmacother , vol.68 , Issue.5 , pp. 507-513
    • He, S.1    Zhou, H.2    Zhu, X.3    Hu, S.4    Fei, M.5    Wan, D.6
  • 32
    • 84893156862 scopus 로고    scopus 로고
    • Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients
    • Liu Z, Dai W, Jiang L, Cheng Y. Over-expression of LGR5 correlates with poor survival of colon cancer in mice as well as in patients. Neoplasma. 2014;61(2):177-85.
    • (2014) Neoplasma , vol.61 , Issue.2 , pp. 177-185
    • Liu, Z.1    Dai, W.2    Jiang, L.3    Cheng, Y.4
  • 34
    • 57049162405 scopus 로고    scopus 로고
    • Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice
    • Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, et al. Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice. Hum Mol Genet. 2008;17(24):3864-75.
    • (2008) Hum Mol Genet , vol.17 , Issue.24 , pp. 3864-3875
    • Segditsas, S.1    Sieber, O.2    Deheragoda, M.3    East, P.4    Rowan, A.5    Jeffery, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.