Hydrogen peroxide-producing lactobacilli are associated with lower levels of vaginal interleukin-1β, independent of bacterial vaginosis

Sexually Transmitted Diseases

Volumn 42, Issue 7, 2015, Pages 358-363

  Mitchell, Caroline ^a   Fredricks, David ^b   Agnew, Kathy ^c   Hitti, Jane ^c  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA DEFENSIN 2; BIOLOGICAL MARKER; HYDROGEN PEROXIDE; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR;

ADULT; ARTICLE; ATOPOBIUM VAGINAE; BACTERIUM CULTURE; BACTERIUM DETECTION; CONTROLLED STUDY; FEMALE; GARDNERELLA VAGINALIS; HUMAN; IMMUNOMODULATION; INFLAMMATION; LACTOBACILLUS; LACTOBACILLUS CRISPATUS; LACTOBACILLUS INERS; LACTOBACILLUS JENSENII; LEPTOTRICHIA; MAJOR CLINICAL STUDY; MEGASPHAERA; NONHUMAN; POLYMERASE CHAIN REACTION; QUANTITATIVE ANALYSIS; VAGINA DISCHARGE; VAGINA SMEAR; VAGINITIS; HETEROZYGOTE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MICROBIOLOGY; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDY; UNITED STATES; VAGINA; VAGINOSIS, BACTERIAL;

ADULT; CARRIER STATE; FEMALE; HUMANS; HYDROGEN PEROXIDE; LACTOBACILLUS; PREGNANCY; PREGNANCY COMPLICATIONS, INFECTIOUS; PROSPECTIVE STUDIES; UNITED STATES; VAGINA; VAGINAL SMEARS; VAGINOSIS, BACTERIAL;

EID: 84953874022     PISSN: 01485717     EISSN: 15374521     Source Type: Journal    
DOI: 10.1097/OLQ.0000000000000298     Document Type: Article

References (38)

1. Ravel J, Gajer P, Abdo Z, et al. Vaginal microbiome of reproductiveagewomen. Proc Natl Acad Sci U S A 2010; 108(suppl 1): 4680-4687.
2. O'Hanlon DE, Moench TR, Cone RA. Vaginal pH and microbicidal lactic acid when lactobacilli dominate the microbiota. PLoS One 2013; 8: E80074.
3. Vallor AC, Antonio MA, Hawes SE, et al. Factors associated with acquisition of, or persistent colonization by, vaginal lactobacilli: Role of hydrogen peroxide production. J Infect Dis 2001; 184(11): 1431-1436.
4. Martius J, Krohn MA, Hillier SL, et al. Relationships of vaginal Lactobacillus species, cervical Chlamydia trachomatis, and bacterial vaginosis to preterm birth. Obstet Gynecol 1988; 71: 89-95.
5. Martin HL, Richardson BA, Nyange PM, et al. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180: 1863-1868.
6. Moore DE, Soules MR, Klein NA, et al. Bacteria in the transfer catheter tip influence the live-birth rate after in vitro fertilization. Fertil Steril 2000; 74: 1118-1124.
7. Fredricks DN, Fiedler TL, Marrazzo JM. Molecular identification of bacteria associated with bacterial vaginosis. N Engl J Med 2005; 353: 1899-1911.
8. Hillier SL, Nugent RP, Eschenbach DA, et al. Association between bacterial vaginosis and preterm delivery of a low-birth-weight infant. The Vaginal Infections and Prematurity Study Group. N Engl J Med 1995; 333: 1737-1742.
9. Hay PE, Lamont RF, Taylor-Robinson D, et al. Abnormal bacterial colonisation of the genital tract and subsequent preterm delivery and late miscarriage. BMJ 1994; 308: 295-298.
10. Romero R, Espinoza J, Goncalves LF, et al. The role of inflammation and infection in preterm birth. Semin Reprod Med 2007; 25: 21-39.
11. Mlisana K, Naicker N,Werner L, et al. Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high-risk women in South Africa. J Infect Dis 2012; 206: 6-14.
12. Morrison C, Fichorova R, Mauck C, et al. Cervical inflammation and immunity associated with hormonal contraception, pregnancy and HIV-1 seroconversion. J Acquir Immune Defic Syndr 2014; 66: 109-117.
13. Raiche E, Ouellet A, Berthiaume M, et al. Short and inflamed cervix predicts spontaneous preterm birth (COLIBRI study). J Matern Fetal Neonatal Med 2014; 27: 1015-1019.
14. Taylor BD, Holzman CB, Fichorova RN, et al. Inflammation biomarkers in vaginal fluid and preterm delivery. Hum Reprod 2013; 28: 942-952.
15. Ghosh M, Fahey JV, Shen Z, et al. Anti-HIV activity in cervicalvaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies. PLoS One 2010; 5: E11366.
16. Mitchell C, Marrazzo J. Bacterial vaginosis and the cervicovaginal immune response. Am J Reprod Immunol 2014; 71: 555-563.
17. Rose WA 2nd, McGowin CL, Spagnuolo RA, et al. Commensal bacteria modulate innate immune responses of vaginal epithelial cell multilayer cultures. PLoS One 2012; 7: E32728.
18. Mackos AR, Eubank TD, Parry NM, et al. Probiotic Lactobacillus reuteri attenuates the stressor-enhanced severity of Citrobacter rodentium infection. Infect Immun 2013; 81: 3253-3263.
19. Eschenbach DA, Patton DL, Meier A, et al. Effects of oral contraceptive pill use on vaginal flora and vaginal epithelium. Contraception 2000; 62: 107-112.
20. Mitchell C, Balkus J, Agnew K, et al. Changes in the vaginal microenvironment withmetronidazole treatment for bacterial vaginosis in early pregnancy. J Womens Health (Larchmt) 2009; 18: 1817-1824.
21. Mitchell C, Gottsch ML, Liu C, et al. Associations between vaginal bacteria and levels of vaginal defensins in pregnant women. Am J Obstet Gynecol 2013; 208: 132.e1-132.e7.
22. Srinivasan S, Liu C, MitchellCM, et al. Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis. PLoS One 2010; 5: E10197.
23. Fredricks DN, Fiedler TL, Thomas KK, et al. Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol 2009; 47: 721-726.
24. Ryckman KK, Williams SM, Krohn MA, et al. Racial differences in cervical cytokine concentrations between pregnant women with and without bacterial vaginosis. J Reprod Immunol 2008; 78: 166-171.
25. Zhou X, Brown CJ, Abdo Z, et al. Differences in the composition of vaginal microbial communities found in healthy Caucasian and black women. ISME J 2007; 1: 121-133.
26. Patterson JL, Girerd PH, Karjane NW, et al. Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid. Am J Obstet Gynecol 2007; 197: 170.e1-170.e7.
27. Eschenbach DA, Davick PR, Williams BL, et al. Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol 1989; 27: 251-256.
28. Klebanoff SJ, Kazazi F. Inactivation of human immunodeficiency virus type 1 by the amine oxidase-peroxidase system. J ClinMicrobiol 1995; 33: 2054-2057.
29. O'Hanlon DE, Lanier BR, Moench TR, et al. Cervicovaginal fluid and semen block the microbicidal activity of hydrogen peroxide produced by vaginal lactobacilli. BMC Infect Dis 2010; 10: 120.
30. Muench DF, Kuch DJ, Wu H, et al. Hydrogen peroxide-producing lactobacilli inhibit gonococci in vitro but not during experimental genital tract infection. J Infect Dis 2009; 199: 1369-1378.
31. O'Hanlon DE, Moench TR, Cone RA. In vaginal fluid, bacteria associated with bacterial vaginosis can be suppressed with lactic acid but not hydrogen peroxide. BMC Infect Dis 2011; 11: 200.
32. Anderson BL, Cu-Uvin S, Raker CA, et al. Subtle perturbations of genital microflora alter mucosal immunity among low-risk pregnant women. Acta Obstet Gynecol Scand 2011; 90: 510-515.
33. Hemalatha R, Mastromarino P, Ramalaxmi BA, et al. Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines: A randomized, doubleblind study. Eur J Clin Microbiol Infect Dis 2012; 31: 3097-3105.
34. Atassi F, Brassart D, Grob P, et al. Lactobacillus strains isolated from the vaginal microbiota of healthy women inhibit Prevotella bivia and Gardnerella vaginalis in coculture and cell culture. FEMS Immunol Med Microbiol 2006; 48: 424-432.
35. Matu MN, Orinda GO, Njagi EN, et al. In vitro inhibitory activity of human vaginal lactobacilli against pathogenic bacteria associated with bacterial vaginosis in Kenyan women. Anaerobe 2010; 16: 210-215.
36. Ngugi BM, Hemmerling A, Bukusi EA, et al. Effects of bacterial vaginosis-associated bacteria and sexual intercourse on vaginal colonization with the probiotic Lactobacillus crispatus CTV-05. Sex Transm Dis 2011; 38: 1020-1027.
37. Kalyoussef S, Nieves E, Dinerman E, et al. Lactobacillus proteins are associated with the bactericidal activity against E. coli of female genital tract secretions. PLoS One 2012; 7: E49506.
38. Stapleton AE, Au-YeungM, Hooton TM, et al. Randomized, placebocontrolled phase 2 trial of a Lactobacillus crispatus probiotic given intravaginally for prevention of recurrent urinary tract infection. Clin Infect Dis 2011; 52: 1212-1217.