Effectiveness of vaginal tablets containing lactobacilli versus pH tablets on vaginal health and inflammatory cytokines: A randomized, double-blind study

European Journal of Clinical Microbiology and Infectious Diseases

Volumn 31, Issue 11, 2012, Pages 3097-3105

  Hemalatha, R ^a   Mastromarino, P ^b   Ramalaxmi, B A ^a   Balakrishna, N V ^a   Sesikeran, B ^a  

^a NATIONAL INSTITUTE OF NUTRITION   (India)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; PROBIOTIC AGENT; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR ALPHA;

ABSENCE OF SIDE EFFECTS; ADULT; ARTICLE; BEDTIME DOSAGE; CLINICAL EFFECTIVENESS; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DOUBLE BLIND PROCEDURE; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INFLAMMATION; LACTOBACILLUS BREVIS; LACTOBACILLUS PLANTARUM; LACTOBACILLUS SALIVARIUS; LEUKORRHEA; MAJOR CLINICAL STUDY; MICROFLORA; PH; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REPRODUCTIVE HEALTH; TABLET; VAGINA CANDIDIASIS; VAGINA DISCHARGE; VAGINA FLORA; VAGINAL LAVAGE; VAGINITIS;

ADMINISTRATION, INTRAVAGINAL; ADULT; CARBOXYLIC ACIDS; CYTOKINES; DOUBLE-BLIND METHOD; DRUG TOXICITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; LACTOBACILLUS; PROBIOTICS; TREATMENT OUTCOME; VAGINA; VAGINAL CREAMS, FOAMS, AND JELLIES; VAGINAL DOUCHING; VAGINOSIS, BACTERIAL; YOUNG ADULT;

EID: 84868001390     PISSN: 09349723     EISSN: 14354373     Source Type: Journal    
DOI: 10.1007/s10096-012-1671-1     Document Type: Article

References (33)

1. Gage JR, Sandhu AK, Nihira M, da Bonecini-Almeida MG, Cristoforoni P, Kishimoto T, Montz FJ, Martínez-Maza O (2000) Effects of human papillomavirus-associated cells on human immunodeficiency virus gene expression. Obstet Gynecol 96(6):879-885
2. Fan SR, Liu XP, Liao QP (2008) Human defensins and cytokines in vaginal lavage fluid of women with bacterial vaginosis. Int J Gynaecol Obstet 103(1):50-54
3. Bhalla P, Chawla R, Garg S, Singh MM, Raina U, Bhalla R, Sodhanit P (2007) Prevalence of bacterial vaginosis among women in Delhi, India. Indian J Med Res 125(2):167-172
4. Madhivanan P, Krupp K, Chandrasekaran V, Karat C, Arun A, Cohen CR, Reingold AL, Klausner JD (2008) Prevalence and correlates of bacterial vaginosis among young women of reproductive age in Mysore, India. Indian J Med Microbiol 26(2):132-137
5. Bang RA, Bang AT, Baitule M, Choudhary Y, Sarmukaddam S, Tale O (1989) High prevalence of gynaecological diseases in rural Indian women. Lancet 1(8629):85-88
6. Sumati AH, Saritha NK (2009) Bacterial vaginosis with special reference to anaerobes. Indian J Pathol Microbiol 52(1):56-58
7. Taha TE, Hoover DR, Dallabetta GA, Kumwenda NI, Mtimavalye LA, Yang LP, Liomba GN, Broadhead RL, Chiphangwi JD, Miotti PG (1998) Bacterial vaginosis and disturbances of vaginal flora: association with increased acquisition of HIV. AIDS 12(13):1699-1706
8. Sha BE, Zariffard MR, Wang QJ, Chen HY, Bremer J, Cohen MH, Spear GT (2005) Female genital-tract HIV load correlates inversely with Lactobacillus species but positively with bacterial vaginosis and Mycoplasma hominis. J Infect Dis 191(1):25-32
9. Sturm-Ramirez K, Gaye-Diallo A, Eisen G, Mboup S, Kanki PJ (2000) High levels of tumor necrosis factor-alpha and interleukin-1beta in bacterial vaginosis may increase susceptibility to human immunodeficiency virus. J Infect Dis 182(2):467-473
10. Osborn L, Kunkel S, Nabel GJ (1989) Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 86(7):2336-2340
11. Leitich H, Bodner-Adler B, Brunbauer M, Kaider A, Egarter C, Husslein P (2003) Bacterial vaginosis as a risk factor for preterm delivery: a meta-analysis. Am J Obstet Gynecol 189(1):139-147
12. Leitich H, Brunbauer M, Bodner-Adler B, Kaider A, Egarter C, Husslein P (2003) Antibiotic treatment of bacterial vaginosis in pregnancy: a meta-analysis. Am J Obstet Gynecol 188(3):752-758
13. Andrews WW, Goldenberg RL, Hauth JC, Cliver SP, Copper R, Conner M (2006) Interconceptional antibiotics to prevent spontaneous preterm birth: a randomized clinical trial. Am J Obstet Gynecol 194(3):617-623
14. Romero R, Espinoza J, Gonçalves LF, Kusanovic JP, Friel L, Hassan S (2007) The role of inflammation and infection in preterm birth. Semin Reprod Med 25(1):21-39
15. Basso B, Giménez F, López C (2005) IL-1beta, IL-6 and IL-8 levels in gyneco-obstetric infections. Infect Dis Obstet Gynecol 13(4):207-211
16. Hedges SR, Barrientes F, Desmond RA, Schwebke JR (2006) Local and systemic cytokine levels in relation to changes in vaginal flora. J Infect Dis 193(4):556-562
17. Genc MR, Witkin SS, Delaney ML, Paraskevas LR, Tuomala RE, Norwitz ER, Onderdonk AB (2004) A disproportionate increase in IL-1beta over IL-1ra in the cervicovaginal secretions of pregnant women with altered vaginal microflora correlates with preterm birth. Am J Obstet Gynecol 190(5):1191-1197
18. González Bosquet E, Ferrer I, Valls C, Borrás M, Lailla JM (2005) The value of interleukin-8, interleukin-6 and interleukin-1beta in vaginal wash as predictors of preterm delivery. Gynecol Obstet Invest 59(3):175
19. Bahamondes MV, Portugal PM, Brolazo EM, Simões JA, Bahamondes L (2011) Use of a lactic acid plus lactoserum intimate liquid soap for external hygiene in the prevention of bacterial vaginosis recurrence after metronidazole oral treatment. Rev Assoc Med Bras 57(4):415-420
20. Petersen EE, Genet M, Caserini M, Palmieri R (2011) Efficacy of vitamin C vaginal tablets in the treatment of bacterial vaginosis: a randomised, double blind, placebo controlled clinical trial. Arzneimittelforschung 61(4):260-265
21. Hemalatha R, Ramalaxmi BA, Krishnaswetha G, Kumar PU, Rao DM, Balakrishna N, Annapurna V. Cervicovaginal inflammatory cytokines and sphingomyelinase in women with and without bacterial vaginosis. Am J Med Sci. 2011 Nov 16. [Epub ahead of print]
22. Delcenserie V, Martel D, Lamoureux M, Amiot J, Boutin Y, Roy D (2008) Immunomodulatory effects of probiotics in the intestinal tract. Curr Issues Mol Biol 10(1-2):37-54
23. Finnegan CM, Rawat SS, Puri A, Wang JM, Ruscetti FW, Blumenthal R (2004) Ceramide, a target for antiretroviral therapy. Proc Natl Acad Sci USA 101(43):15452-15457
24. Nugent RP, Krohn MA, Hillier SL (1991) Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 29(2):297-301
25. Amsel R, Totten PA, Spiegel CA, Chen KC, Eschenbach D, Holmes KK (1983) Nonspecific vaginitis. Diagnostic criteria and microbial and epidemiologic associations. Am J Med 74(1):14-22
26. Rybakina EG, Nalivaeva NN, Pivanovich YU, Shanin SN, Kozinets A, Korneva EA (2001) The role of neutral sphingomyelinase in interleukin-1beta signal transduction in mouse cerebral cortex cells. Neurosci Behav Physiol 31(4):439-444
27. Mastromarino P, Macchia S, Meggiorini L, Trinchieri V, Mosca L, Perluigi M, Midulla C (2009) Effectiveness of Lactobacillus-containing vaginal tablets in the treatment of symptomatic bacterial vaginosis. Clin Microbiol Infect 15(1):67-74
28. Brzezinski A, Stern T, Arbel R, Rahav G, Benita S (2004) Efficacy of a novel pH-buffering tampon in preserving the acidic vaginal pH during menstruation. Int J Gynaecol Obstet 85(3):298-300
29. Holley RL, Richter HE, Varner RE, Pair L, Schwebke JR (2004) A randomized, double-blind clinical trial of vaginal acidification versus placebo for the treatment of symptomatic bacterial vaginosis. Sex Transm Dis 31(4):236-238
30. Yasodhara P, Raghunath M, Sreeramulu D, Venu L, Hemalatha R, Krishna TP (2006) Local immunity in Indian women with bacterial vaginosis. J Reprod Immunol 70(1-2):133-141
31. Cauci S, Guaschino S, Driussi S, De Santo D, Lanzafame P, Quadrifoglio F (2002) Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis. J Infect Dis 185(11):1614-1620
32. Ravel J, Gajer P, Abdo Z, Schneider GM, Koenig SS, McCulle SL, Karlebach S, Gorle R, Russell J, Tacket CO, Brotman RM, Davis CC, Ault K, Peralta L, Forney LJ (2011) Vaginal microbiome of reproductive-age women. Proc Natl Acad Sci USA 108(Suppl 1):4680-4687
33. Becker KA, Riethmüller J, Lüth A, Döring G, Kleuser B, Gulbins E (2010) Acid sphingomyelinase inhibitors normalize pulmonary ceramide and inflammation in cystic fibrosis. Am J Respir Cell Mol Biol 42(6):716-724