T-type calcium channel blocker Z944 restores cortical synchrony and thalamocortical connectivity in a rat model of neuropathic pain

Pain

Volumn 157, Issue 1, 2016, Pages 255-263

  Leblanc, Brian W ^a   Lii, Theresa R ^a   Huang, Jian Jia ^b   Chao, Yu Chieh ^a,c   Bowary, Paul M ^a   Cross, Brent S ^a   Lee, Margaret S ^d   Vera Portocarrero, Louis P ^e   Saab, Carl Y ^a  

^a Brown University Program in Neurosurgery   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CAPITAL MEDICAL UNIVERSITY   (China)

^d Zalicus Inc   (United States)

^e MEDTRONIC INC   (United States)

Author keywords

Coherence; Oscillation; Phase amplitude coupling; Power; Synchrony; T type calcium

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; UNCLASSIFIED DRUG; Z 944; ACETAMIDE DERIVATIVE; BENZAMIDE DERIVATIVE; Z944 COMPOUND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CENTRAL NERVOUS SYSTEM DRUG ADMINISTRATION; CHRONIC CONSTRICTION INJURY; CONNECTOME; CONTROLLED STUDY; CORTICAL SYNCHRONIZATION; DRUG DOSE ESCALATION; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGICAL PROCEDURES; FOURIER TRANSFORMATION; HYPERALGESIA; INTRATHALAMIC DRUG ADMINISTRATION; MALE; NEUROPATHIC PAIN; NONHUMAN; OSCILLATION; PLACE PREFERENCE; PRIMARY SOMATOSENSORY CORTEX; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE; THALAMOCORTICAL TRACT; THALAMUS VENTRAL NUCLEUS; WAVEFORM; WITHDRAWAL REFLEX; ACTION POTENTIAL; ANIMAL; BRAIN CORTEX; DISEASE MODEL; DRUG EFFECTS; NERVE TRACT; NEURALGIA; PATHOPHYSIOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; THALAMUS;

ACETAMIDES; ACTION POTENTIALS; ANIMALS; BENZAMIDES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; MALE; NEURAL PATHWAYS; NEURALGIA; RATS; RATS, SPRAGUE-DAWLEY; THALAMUS;

EID: 84953747736     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1097/j.pain.0000000000000362     Document Type: Article

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