An examination of dynamic gene expression changes in the mouse brain during pregnancy and the postpartum period

G3: Genes, Genomes, Genetics

Volumn 6, Issue 1, 2016, Pages 221-233

  Ray, Surjyendu ^a,b   Tzeng, Ruei Ying ^a   DiCarlo, Lisa M ^a   Bundy, Joseph L ^a   Vied, Cynthia ^a   Tyson, Gary ^a,b   Nowakowski, Richard ^a   Arbeitman, Michelle N ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b Florida State University   (United States)

Author keywords

Expression; Gene; Genetics of sex; Mouse; Parturition; Postpartum; Pregnancy; Rna seq

Indexed keywords

5 AMINOLEVULINATE SYNTHASE; BONE MORPHOGENETIC PROTEIN; CELL NUCLEUS RECEPTOR; CYSTEINE RICH PROTEIN 61; FOS LIKE ANTIGEN 2; G PROTEIN COUPLED RECEPTOR; HEMOGLOBIN A2; HEMOGLOBIN BETA CHAIN; KRUPPEL LIKE FACTOR 2; MESSENGER RNA; NEURONAL PAS DOMAIN PROTEIN 4; NEUROPEPTIDE RECEPTOR; NEUROTRANSMITTER TRANSPORTER; OXYTOCIN; PROTEIN FOS; SOMATOMEDIN; SOMATOMEDIN BINDING PROTEIN 4; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG; TRANSCRIPTOME;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; CEREBELLUM; EARLY RESPONSE GENE; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; MALE; MATERNAL BEHAVIOR; MOUSE; NEOCORTEX; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PREGNANCY; PUERPERAL DEPRESSION; PUERPERIUM; RNA SEQUENCE; ANIMAL; ANIMAL BEHAVIOR; BIOLOGY; CLUSTER ANALYSIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; GENETICS; HIGH THROUGHPUT SEQUENCING; HUMAN; METABOLISM; POSTNATAL DEPRESSION; PROCEDURES;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DEPRESSION, POSTPARTUM; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE ONTOLOGY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MICE; PHENOTYPE; POSTPARTUM PERIOD; PREGNANCY; TRANSCRIPTOME;

EID: 84953732913     PISSN: None     EISSN: 21601836     Source Type: Journal    
DOI: 10.1534/g3.115.020982     Document Type: Article

References (46)

1. Andersson, L., I. Sundstrom-Poromaa, M. Wulff, M. Astrom, and M. Bixo, 2006 Depression and anxiety during pregnancy and six months post- partum: a follow-up study. Acta Obstet. Gynecol. Scand. 85: 937-944.
2. Andrews, S., 2010 A quality control tool for high throughput sequence data, Reference Source, Fast, QC. Benjamini, Y., and Y. Hochberg, 1995 Controlling the false discovery rate- a practical and powerful approach to multiple testing. J Roy Stat Soc B Met 57: 289-300.
3. Bolger, A. M., M. Lohse, and B. Usadel, 2014 Trimmomatic: A ?exible trimmer for Illumina Sequence Data. Bioinformatics. doi: 10.1093/ bioinformatics/btu170
4. Bridges, R. S., 1984 A quantitative analysis of the roles of dosage, sequence, and duration of estradiol and progesterone exposure in the regulation of maternal behavior in the rat. Endocrinology 114: 930-940.
5. Bridges, R. S., M. Numan, P. M. Ronsheim, P. E. Mann, and C. E. Lupini, 1990 Central prolactin infusions stimulate maternal behavior in steroid- treated, nulliparous female rats. Proc. Natl. Acad. Sci. USA 87: 8003-8007.
6. Brown, J. R., H. Ye, R. T. Bronson, P. Dikkes, and M. E. Greenberg, 1996 A defect in nurturing in mice lacking the immediate early gene fosB. Cell 86: 297-309.
7. Brunton, P. J., and J. A. Russell, 2008 The expectant brain: adapting for motherhood. Nat. Rev. Neurosci. 9: 11-25.
8. Brunton, P. J., and J. A. Russell, 2010 Endocrine induced changes in brain function during pregnancy. Brain Res. 1364: 198-215.
9. Delhomme, N., I. Padioleau, E. E. Furlong, and L. M. Steinmetz, 2012 easyRNASeq: a bioconductor package for processing RNA-Seq data. Bioinformatics 28: 2532-2533.
10. Dulac, C., and L. O'Connell, and Z. Wu, 2014 Neural control of maternal and paternal behaviors. Science 345: 765-770.
11. Eisinger, B. E., C. J. Zhao, T. M. Driessen, M. C. Saul, and S. C. Gammie, 2013 Large scale expression changes of genes related to neuronal sig- naling and developmental processes found in lateral septum of postpar- tum outbred mice. PLoS One 8: e63824.
12. Flicek, P., M.R. Amode, D. Barrell, K. Beal, K. Billis, S. Brent, D. Carvalho-Silva, P. Clapham, G. Coates, S. Fitzgerald et al., 2014 Ensembl 2014. Nucleic Acids Res. 42: D749-D755
13. Galea, L. A., B. Leuner, and D. A. Slattery, 2014 Hippocampal plasticity during the peripartum period: influence of sex steroids, stress and ageing. J. Neuroendocrinol. 26: 641-648.
14. Gonzalez-Mariscal, G., A. I. Melo, P. Jimenez, C. Beyer, and J. S. Rosenblatt, 1996 Estradiol, progesterone, and prolactin regulate maternal nest-building in rabbits. J. Neuroendocrinol. 8: 901-907.
15. Hillerer, K. M., V. R. Jacobs, T. Fischer, and L. Aigner, 2014 The maternal brain: an organ with peripartal plasticity. Neural Plast. 2014: 574159
16. Horseman, N.D., W.Zhao, E.Montecino-Rodriguez, M.Tanaka, K.Nakashima et al., 1997 Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene. EMBO J. 16: 6926-6935.
17. Hull, K. L., and S. Harvey, 2002 GH as a co-gonadotropin: The relevance of correlative changes in GH secretion and reproductive state. J. Endocrinol. 172: 1-19.
18. Jiang, L., F. Schlesinger, C. A. Davis, Y. Zhang, R. Li et al., 2011 Synthetic spike-in standards for RNA-seq experiments. Genome Res. 21: 1543-1551.
19. Josefsson, A., G. Berg, C. Nordin, and G. Sydsjo, 2001 Prevalence of de- pressive symptoms in late pregnancy and postpartum. Acta Obstet. Gynecol. Scand. 80: 251-255.
20. Kaimal, V., E. E. Bardes, S. C. Tabar, A. G. Jegga, and B. J. Aronow, 2010 ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological sys- tems. Nucleic Acids Res. 38: W96-W102.
21. Kanehisa, M., and S. Goto, 2000 KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28: 27-30.
22. Kinsley, C. H., and E. Amory-Meyer, 2011 Why the maternal brain? J. Neuroendocrinol. 23: 974-983.
23. Kinsley, C. H., L. Madonia, G. W. Gifford, K. Tureski, G. R. Griffin et al., 1999 Motherhood improves learning and memory. Nature 402: 137-138.
24. Larsen, C. M., and D. R. Grattan, 2012 Prolactin, neurogenesis, and ma- ternal behaviors. Brain Behav. Immun. 26: 201-209.
25. Lein, E. S., M. J. Hawrylycz, N. Ao, M. Ayres, A. Bensinger et al., 2007 Genome-wide atlas of gene expression in the adult mouse brain. Nature 445: 168-176.
26. Love, M.I., Huber, W., and Anders, S. 2014 Moderated estimation of fold change and dispersion for RNA-Seq data with DESeq2. Genome Biol. 15: 550
27. Mann, P. E., 2014 Gene expression profiling during pregnancy in rat brain tissue. Brain Sci. 4: 125-135.
28. Pawluski, J. L., K. G. Lambert, and C. H. Kinsley, 2015 Neuroplasticity in the maternal hippocampus: Relation to cognition and effects of repeated stress. Horm. Behav. pii: S0018-506X(15)00110-5.
29. Pedersen, C. A., J. D. Caldwell, C. Walker, G. Ayers, and G. A. Mason, 1994 Oxytocin activates the postpartum onset of rat maternal behavior in the ventral tegmental and medial preoptic areas. Behav. Neurosci. 108: 1163-1171.
30. Philipps, L. H., and M. W. O'Hara, 1991 Prospective study of postpartum depression: 4 1/2-year follow-up of women and children. J. Abnorm. Psychol. 100: 151-155.
31. Ponka, P., 1999 Cell biology of heme. Am. J. Med. Sci. 318: 241-256.
32. Rich, M. E., E. J. deCardenas, H. J. Lee, and H. K. Caldwell, 2014 Impairments in the initiation of maternal behavior in oxytocin receptor knockout mice. PLoS One 9: e98839.
33. Robinson, M. D., D. J. McCarthy, and G. K. Smyth, 2010 edgeR: a Bio- conductor package for differential expression analysis of digital gene expression data. Bioinformatics 26: 139-140.
34. Russell, J. A., A. J. Douglas, and C. D. Ingram, 2001 Brain preparations for maternity-adaptive changes in behavioral and neuroendocrine systems during pregnancy and lactation. An overview. Prog. Brain Res. 133: 1-38.
35. Russell, J. A., G. Leng, and A. J. Douglas, 2003 The magnocellular oxytocin system, the fount of maternity: adaptations in pregnancy. Front. Neuro- endocrinol. 24: 27-61.
36. Sandberg, R., R. Yasuda, D. G. Pankratz, T. A. Carter, J. A. Del Rio et al., 2000 Regional and strain-specific gene expression mapping in the adult mouse brain. Proc. Natl. Acad. Sci. USA 97: 11038-11043.
37. Slotnick, B. M., 1967 Disturbances of maternal behavior in the rat following lesions of the cingulate cortex. Behaviour 29: 204-236.
38. Slotnick, B. M., and B. J. Nigrosh, 1975 Maternal behavior of mice with cingulate cortical, amygdala, or septal lesions. J. Comp. Physiol. Psychol. 88: 118-127.
39. Stein, G., A. Marsh, and J. Morton, 1981 Mental symptoms, weight changes, and electrolyte excretion in the first post partum week. J. Psy- chosom. Res. 25: 395-408.
40. Theiler, K., 1989 The House Mouse: Atlas of Embryonic Development, Springer-Verlag, New York.
41. Trapnell, C., L. Pachter, and S. L. Salzberg, 2009 TopHat: discovering splice junctions with RNA-Seq. Bioinformatics 25: 1105-1111.
42. Trapnell, C., A. Roberts, and L. Goff, 2012 Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cuffiinks. Nat. Protoc. 7: 562-578.
43. West, A.E., and Greenberg, M.E. (2011) Neuronal activity-regulated gene transcription in synapse development and cognitive function. Cold Spring Harb. Perspect. Biol. 3: pii: a005744. doi: 10.1101/cshperspect.a005744
44. a005744 Yu, W., M. Clyne, M. J. Khoury, and M. Gwinn, 2010 Phenopedia and Genopedia: disease-centered and gene-centered views of the evolving knowledge of human genetic associations. Bioinformatics 26: 145-146.
45. Zhang, B., S. Kirov, and J. Snoddy, 2005 Web Gestalt: an integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res. 33: W741-W748.
46. Zhao, C. J., M. C. Saul, T. Driessen, and S. C. Gammie, 2012 Gene ex- pression changes in the septum: possible implications for microRNAs in sculpting the maternal brain. PLoS One 7: e38602.