MicroRNA activation signature in patients with hemophagocytic lymphohistiocytosis and reversibility with disease-specific therapy

Journal of Allergy and Clinical Immunology

Volumn 137, Issue 1, 2016, Pages 309-312

  Sumegi, Janos ^a   Nestheide, Shawnagay ^a   Aronow, Bruce ^a   Fletcher, David ^a   Keddache, Mehdi ^a   Villanueva, Joyce ^a   Zhang, Kejian ^a   Filipovich, Alexandra H ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL2 CHEMOKINE; CYCLIC AMP; DEXAMETHASONE; ETOPOSIDE; GRANZYME B; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; METHOTREXATE; MICRORNA; MICRORNA 101; MICRORNA 16; MICRORNA 181A; MICRORNA 19A; MICRORNA 19B; MICRORNA 21; MICRORNA 223; MICRORNA 30E; MICRORNA LET 7E; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PERFORIN; STRESS ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; B LYMPHOCYTE; BONE MARROW CELL; CD4 LYMPHOCYTE COUNT; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CYCLIC AMP BLOOD LEVEL; CYTOKINE PRODUCTION; CYTOTOXICITY; DISEASE ACTIVITY; DISEASE ASSOCIATION; DISEASE COURSE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME INACTIVATION; GAMMA DELTA T LYMPHOCYTE; HEMOPHAGOCYTIC SYNDROME; HUMAN; INFLAMMATION; INNATE IMMUNITY; LETTER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE FUNCTION; MACROPHAGE; MACROPHAGE ACTIVATION; MICRORNA ACTIVATION; NATURAL KILLER CELL; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; REGULATORY T LYMPHOCYTE; REMISSION; RNA SEQUENCE; SIGNAL TRANSDUCTION; TH1 CELL; TH2 CELL; UPREGULATION; ADOLESCENT; CHILD; FEMALE; GENETICS; INFANT; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; METABOLISM; MONONUCLEAR CELL; PRESCHOOL CHILD;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; LEUKOCYTES, MONONUCLEAR; LYMPHOHISTIOCYTOSIS, HEMOPHAGOCYTIC; MALE; MICRORNAS;

EID: 84953638048     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.06.006     Document Type: Article

References (9)

1. M.B. Jordan, C.E. Allen, S. Weitzman, A.H. Filipovich, and K.L. McClain How I treat hemophagocytic lymphohistiocytosis Blood 118 2011 4041 4052
2. A. Rebane, and C.A. Akdis MicroRNAs: essential players in the regulation of inflammation J Allergy Clin Immunol 132 2013 15 26
3. J. Sumegi, M.G. Barnes, S.V. Nestheide, S. Molleran-Lee, J. Villanueva, K. Zhang, and et al. Gene expression profiling of peripheral blood mononuclear cells from children with active hemophagocytic lymphohistiocytosis Blood 117 2011 e151 e160
4. C. Wu, E.E. Bardes, A.G. Jegga, and B.J. Aronow ToppMiR: ranking microRNAs and their mRNA targets based on biological functions and context Nucleic Acids Res 42 Web Server issue 2014 W107 W113
5. REG cells by targeting AC9 mRNA EMBO Rep 10 2009 180 185
6. F.J. Sheedy, E. Palsson-McDermott, E.J. Hennessy, C. Martin, J.J. O'Leary, Q. Ruan, and et al. Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 Nat Immunol 11 2010 141 147
7. Y. Zhang, M. Zhang, M. Zhong, Q. Suo, and K. Lv Expression profiles of miRNAs in polarized macrophages Int J Mol Med 31 2013 797 802
8. J. Wang, Y.W. Lu, M.M. Lu, R.X. Leng, H.F. Pan, and D.Q. Ye MicroRNA-101, mitogen-activated protein kinases and mitogen-activated protein kinases phosphatase-1 in systemic lupus erythematosus Lupus 22 2013 115 120
9. P. Wang, Y. Gu, Q. Zhang, Y. Han, J. Hou, L. Lin, and et al. Identification of resting and type I IFN-activated human NK cell miRNomes reveals microRNA-378 and microRNA-30e as negative regulators of NK cell cytotoxicity J Immunol 189 2012 211 221