Improving Outcomes in Patients With Sepsis

American Journal of Medical Quality

Volumn 31, Issue 1, 2016, Pages 56-63

  Armen, Scott B ^a   Freer, Carol V ^a   Showalter, John W ^a   Crook, Tonya ^a   Whitener, Cynthia J ^a   West, Cheri ^a   Terndrup, Thomas E ^a   Grifasi, Marissa ^a   DeFlitch, Christopher J ^a   Hollenbeak, Christopher S ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

evidence based medicine; interdisciplinary health team; outcomes assessment; quality improvement; sepsis; severe sepsis

Indexed keywords

ANTIINFECTIVE AGENT;

ALGORITHM; CARE BUNDLE; CLINICAL PROTOCOL; COMORBIDITY; ECONOMICS; EVIDENCE BASED PRACTICE; FEMALE; HOSPITAL CHARGE; HOSPITAL MORTALITY; HUMAN; IN SERVICE TRAINING; INTENSIVE CARE UNIT; LENGTH OF STAY; MALE; MORTALITY; ORGANIZATION AND MANAGEMENT; SEPSIS; TOTAL QUALITY MANAGEMENT; TREATMENT OUTCOME; UNIVERSITY HOSPITAL;

ACADEMIC MEDICAL CENTERS; ALGORITHMS; ANTI-INFECTIVE AGENTS; CLINICAL PROTOCOLS; COMORBIDITY; EVIDENCE-BASED PRACTICE; FEMALE; HOSPITAL CHARGES; HOSPITAL MORTALITY; HUMANS; INSERVICE TRAINING; INTENSIVE CARE UNITS; LENGTH OF STAY; MALE; PATIENT CARE BUNDLES; QUALITY IMPROVEMENT; SEPSIS; TREATMENT OUTCOME;

EID: 84953450011     PISSN: 10628606     EISSN: 1555824X     Source Type: Journal    
DOI: 10.1177/1062860614551042     Document Type: Article

References (29)

1. D.C.AngusR.S.Wax. Epidemiology of sepsis: an update. Crit Care Med. 2001;29(7 suppl):S109-S116.
2. R.C.BoneR.A.BalkF.B.Cerra. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest. 1992;101:1644-1655.
3. G.FriedmanE.SilvaJ.L.Vincent. Has the mortality of septic shock changed with time. Crit Care Med. 1998;26:2078-2086.
4. C.AlbertiC.Brun-BuissonH.Burchardi. Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study. Intensive Care Med. 2002;28:108-121.
5. G.S.MartinD.M.ManninoS.EatonM.Moss. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-1554.
6. E.RiversB.NguyenS.Havstad. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-1377.
7. R.M.OteroH.B.NguyenD.T.Huang. Early goal-directed therapy in severe sepsis and septic shock revisited: concepts, controversies, and contemporary findings. Chest. 2006;130:1579-1595.
8. R.P.DellingerJ.M.CarletH.Masur. Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock. Crit Care Med. 2004;32:858-873.
9. R.P.DellingerM.M.LevyJ.M.Carlet. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med. 2008;34:17-60.
10. M.M.LevyR.P.DellingerS.R.Townsend. The Surviving Sepsis Campaign: results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36:222-231.
11. H.ZhaoS.O.HeardM.T.Mullen. An evaluation of the diagnostic accuracy of the 1991 American College of Chest Physicians/Society of Critical Care Medicine and the 2001 Society of Critical Care Medicine/European Society of Intensive Care Medicine/American College of Chest Physicians/American Thoracic Society/Surgical Infection Society sepsis definition. Crit Care Med. 2012;40:1700-1706.
12. M.PoezeG.RamsayH.GerlachF.RubulottaM.Levy. An international sepsis survey: a study of doctors’ knowledge and perception about sepsis. Crit Care. 2004;8:R409-R413.
13. S.HarbarthJ.GarbinoJ.PuginJ.A.RomandD.LewD.Pittet. Inappropriate initial antimicrobial therapy and its effect on survival in a clinical trial of immunomodulating therapy for severe sepsis. Am J Med. 2003;115:529-535.
14. E.H.IbrahimG.ShermanS.WardV.J.FraserM.H.Kollef. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118:146-155.
15. L.LeiboviciI.ShragaM.DruckerH.KonigsbergerZ.SamraS.D.Pitlik. The benefit of appropriate empirical antibiotic treatment in patients with bloodstream infection. J Intern Med. 1998;244:379-386.
16. M.H.KollefG.ShermanS.WardV.J.Fraser. Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest. 1999;115:462-474.
17. R.FerrerA.ArtigasM.M.Levy. Improvement in process of care and outcome after a multicenter severe sepsis educational program in Spain. JAMA. 2008;299:2294-2303.
18. K.JeonT.G.ShinM.S.Sim. Improvements in compliance with resuscitation bundles and achievement of end points after an educational program on the management of severe sepsis and septic shock. Shock. 2012;37:463-467.
19. M.GirardisL.RinaldiL.Donno. Effects on management and outcome of severe sepsis and septic shock patients admitted to the intensive care unit after implementation of a sepsis program: a pilot study. Crit Care. 2009;13:R143.
20. N.I.ShapiroM.D.HowellD.Talmor. Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med. 2006;34:1025-1032.
21. A.Castellanos-OrtegaB.SuberviolaL.A.Garcia-Astudillo. Impact of the Surviving Sepsis Campaign protocols on hospital length of stay and mortality in septic shock patients: results of a three-year follow-up quasi-experimental study. Crit Care Med. 2010;38:1036-1043.
22. A.KortgenP.NiederprumM.Bauer. Implementation of an evidence-based “standard operating procedure” and outcome in septic shock. Crit Care Med. 2006;34:943-949.
23. C.M.CannonC.V.HolthausM.T.Zubrow. The GENESIS Project (GENeralized Early Sepsis Intervention Strategies): a multicenter quality improvement collaborative. J Intensive Care Med. 2013;28:355-368.
24. S.TrzeciakR.P.DellingerN.L.Abate. Translating research to clinical practice: a 1-year experience with implementing early goal-directed therapy for septic shock in the emergency department. Chest. 2006;129:225-232.
25. F.GaoT.MelodyD.F.DanielsS.GilesS.Fox. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: a prospective observational study. Crit Care. 2005;9:R764-R770.
26. V.CobaM.WhitmillR.Mooney. Resuscitation bundle compliance in severe sepsis and septic shock: improves survival, is better late than never. J Intensive Care Med. 2011;26:304-343.
27. S.T.MicekN.RoubinianT.Heuring. Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med. 2006;34:2707-2713.
28. S.W.ThielM.F.AsgharS.T.MicekR.M.ReichleyJ.A.DohertyM.H.Kollef. Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis. Crit Care Med. 2009;37:819-824.
29. The ProCESS Investigators; D.M.YealyJ.A.KellumD.T.Huang. A randomized trial of protocol-based care for early septic shock. N Engl J Med. 2014;370:1683-1693.