Single-molecule localization microscopy allows for the analysis of cancer metastasis-specific mirna distribution on the nanoscale

Oncotarget

Volumn 6, Issue 42, 2015, Pages 44745-44757

  Oleksiuk, Olga ^a   Abba, Mohammed ^a   Tezcan, Kerem Can ^a   Schaufler, Wladimir ^b,c   Bestvater, Felix ^b   Patil, Nitin ^a   Birk, Udo ^d   Hafner, Mathias ^e   Altevogt, Peter ^a   Cremer, Christoph ^a,d   Allgayer, Heike ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF KARLSRUHE   (Germany)

^d INSTITUTE OF MOLECULAR BIOLOGY IMB   (Germany)

^e MANNHEIM UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

Localization microscopy; Metastasis; microRNAs; miR 31; Super resolution

Indexed keywords

MICRORNA 31; MICRORNA; MIRN31 MICRORNA, HUMAN;

ARTICLE; CANCER CELL LINE; CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; CLUSTER ANALYSIS; COLORECTAL CANCER CELL LINE; CONTROLLED STUDY; EXOSOME; EXTRACELLULAR SPACE; GENE EXPRESSION; HUMAN; HUMAN CELL; METASTASIS; MICROSCOPY; SINGLE MOLECULE LOCALIZATION MICROSCOPY; COLON TUMOR; COMPARATIVE STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; GENOTYPE; IMAGE PROCESSING; LYMPH NODE METASTASIS; MOLECULAR IMAGING; NANOTECHNOLOGY; PATHOLOGY; PHENOTYPE; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; COLONIC NEOPLASMS; EXOSOMES; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LYMPHATIC METASTASIS; MICRORNAS; MICROSCOPY; MOLECULAR IMAGING; NANOTECHNOLOGY; PHENOTYPE; TRANSFECTION;

EID: 84953449978     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6297     Document Type: Article

References (38)

1. Spano D, Heck C, De AP, Christofori G, Zollo M. Molecular networks that regulate cancer metastasis. SeminCancer Biol. 2012; 22:234-249.
2. Valastyan S, Weinberg RA. Tumor metastasis: molecular insights and evolving paradigms. Cell. 2011; 147:275-292.
3. Meng W, Ye Z, Cui R, Perry J, Dedousi-Huebner V, Huebner A, Wang Y, Li B, Volinia S, Nakanishi H, Kim T, Suh SS, Ayers LW, Ross P, Croce CM, Chakravarti A, et al. MicroRNA-31 predicts the presence of lymph node metastases and survival in patients with lung adenocarcinoma. ClinCancer Res. 2013; 19:5423-5433.
4. Valastyan S, Reinhardt F, Benaich N, Calogrias D, Szasz AM, Wang ZC, Brock JE, Richardson AL, Weinberg RA. A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasis. Cell. 2009; 137:1032-1046.
5. Mitamura T, Watari H, Wang L, Kanno H, Hassan MK, Miyazaki M, Katoh Y, Kimura T, Tanino M, Nishihara H, Tanaka S, Sakuragi N. Downregulation of miRNA-31 induces taxane resistance in ovarian cancer cells through increase of receptor tyrosine kinase MET. Oncogenesis. 2013; 2:e40.
6. Mudduluru G, Abba M, Batliner J, Patil N, Scharp M, Lunavat TR, Leupold JH, Oleksiuk O, Juraeva D, Thiele W, Rothley M, Benner A, Ben-Neriah Y, Sleeman J, Allgayer H. A Systematic Approach to Defining the microRNA Landscape in Metastasis. Cancer research. 2015; 75:3010-3019.
7. Peinado H, Aleckovic M, Lavotshkin S, Matei I, Costa-Silva B, Moreno-Bueno G, Hergueta-Redondo M, Williams C, Garcia-Santos G, Ghajar C, Nitadori-Hoshino A, Hoffman C, Badal K, Garcia BA, Callahan MK, Yuan J, et al. Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET. NatMed. 2012; 18:883-891.
8. Fabbri M. MicroRNAs and cancer: towards a personalized medicine. CurrMolMed. 2013; 13:751-756.
9. Roberts TC. The MicroRNA Biology of the Mammalian Nucleus. Molecular therapy Nucleic acids. 2014; 3:e188.
10. Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. AnnuRevBiochem. 2010; 79:351-379.
11. Leung AK, Sharp PA. Quantifying Argonaute proteins in and out of GW/P-bodies: implications in microRNA activities. AdvExpMedBiol. 2013; 768:165-182.
12. Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, et al. MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response. ProcNatlAcadSciUSA. 2012; 109:E2110-E2116.
13. Itzkovitz S, van OA. Validating transcripts with probes and imaging technology. NatMethods. 2011; 8:S12-S19.
14. Nuovo GJ. In situ detection of microRNAs in paraffin embedded, formalin fixed tissues and the co-localization of their putative targets. Methods. 2010; 52:307-315.
15. Lyubimova A, Itzkovitz S, Junker JP, Fan ZP, Wu X, van OA. Single-molecule mRNA detection and counting in mammalian tissue. NatProtoc. 2013; 8:1743-1758.
16. Hernandez R, Orbay H, Cai W. Molecular imaging strategies for in vivo tracking of microRNAs: a comprehensive review. CurrMedChem. 2013; 20:3594-3603.
17. Lemmer P, Gunkel M, Weiland Y, Muller P, Baddeley D, Kaufmann R, Urich A, Eipel H, Amberger R, Hausmann M, Cremer C. Using conventional fluorescent markers for far-field fluorescence localization nanoscopy allows resolution in the 10-nm range. JMicrosc. 2009; 235:163-171.
18. Kaufmann R, Muller P, Hausmann M, Cremer C. Imaging label-free intracellular structures by localisation microscopy. Micron. 2010.
19. Kaufmann R, Piontek J, Grull F, Kirchgessner M, Rossa J, Wolburg H, Blasig IE, Cremer C. Visualization and quantitative analysis of reconstituted tight junctions using localization microscopy. PLoSOne. 2012; 7:e31128.
20. Kubens BS, Zanker KS. Differences in the migration capacity of primary human colon carcinoma cells (SW480) and their lymph node metastatic derivatives (SW620). Cancer Lett. 1998; 131:55-64.
21. de Vries JE, Dinjens WN, De Bruyne GK, Verspaget HW, van der Linden EP, de Bruine AP, Mareel MM, Bosman FT, ten KJ. In vivo and in vitro invasion in relation to phenotypic characteristics of human colorectal carcinoma cells. BrJCancer. 1995; 71:271-277.
22. Asangani IA, Harms PW, Dodson L, Pandhi M, Kunju LP, Maher CA, Fullen DR, Johnson TM, Giordano TJ, Palanisamy N, Chinnaiyan AM. Genetic and epigenetic loss of microRNA-31 leads to feed-forward expression of EZH2 in melanoma. Oncotarget. 2012; 3:1011-1025.
23. Kaufmann R, Muller P, Hildenbrand G, Hausmann M, Cremer C. Analysis of Her2/neu membrane protein clusters in different types of breast cancer cells using localization microscopy. JMicrosc. 2011; 242:46-54.
24. Raposo G, Stoorvogel W. Extracellular vesicles: exosomes, microvesicles, and friends. JCell Biol. 2013; 200:373-383.
25. Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. NatCell Biol. 2007; 9:654-659.
26. Gyorgy B, Szabo TG, Pasztoi M, Pal Z, Misjak P, Aradi B, Laszlo V, Pallinger E, Pap E, Kittel A, Nagy G, Falus A, Buzas EI. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell MolLife Sci. 2011; 68:2667-2688.
27. Mittelbrunn M, Sanchez-Madrid F. Intercellular communication: diverse structures for exchange of genetic information. NatRevMolCell Biol. 2012; 13:328-335.
28. Turchinovich A, Weiz L, Langheinz A, Burwinkel B. Characterization of extracellular circulating microRNA. Nucleic Acids Res. 2011; 39:7223-7233.
29. Choi DS, Choi DY, Hong BS, Jang SC, Kim DK, Lee J, Kim YK, Kim KP, Gho YS. Quantitative proteomics of extracellular vesicles derived from human primary and metastatic colorectal cancer cells. JExtracellVesicles. 2012; 1.
30. Shivanandan A, Deschout H, Scarselli M, Radenovic A. Challenges in quantitative single molecule localization microscopy. FEBS Lett. 2014.
31. Sauer M. Localization microscopy coming of age: from concepts to biological impact. JCell Sci. 2013; 126:3505-3513.
32. Furstenberg A, Heilemann M. Single-molecule localization microscopy-near-molecular spatial resolution in light microscopy with photoswitchable fluorophores. PhysChemChemPhys. 2013; 15:14919-14930.
33. Cremer C, Kaufmann R, Gunkel M, Pres S, Weiland Y, Muller P, Ruckelshausen T, Lemmer P, Geiger F, Degenhard S, Wege C, Lemmermann NA, Holtappels R, Strickfaden H, Hausmann M. Superresolution imaging of biological nanostructures by spectral precision distance microscopy. BiotechnolJ. 2011; 6:1037-1051.
34. Yang MH, Yu J, Chen N, Wang XY, Liu XY, Wang S, Ding YQ. Elevated microRNA-31 expression regulates colorectal cancer progression by repressing its target gene SATB2. PLoSOne. 2013; 8:e85353.
35. Wang S, Li Q, Wang K, Dai Y, Yang J, Xue S, Han F, Zhang Q, Liu J, Wu W. Decreased expression of microRNA-31 associates with aggressive tumor progression and poor prognosis in patients with bladder cancer. ClinTranslOncol. 2013; 15:849-854.
36. Mitra AK, Zillhardt M, Hua Y, Tiwari P, Murmann AE, Peter ME, Lengyel E. MicroRNAs reprogram normal fibroblasts into cancer-associated fibroblasts in ovarian cancer. Cancer Discov. 2012; 2:1100-1108.
37. Nazarenko I, Rupp AK, Altevogt P. Exosomes as a potential tool for a specific delivery of functional molecules. Methods in molecular biology. 2013; 1049:495-511.
38. Runz S, Keller S, Rupp C, Stoeck A, Issa Y, Koensgen D, Mustea A, Sehouli J, Kristiansen G, Altevogt P. Malignant ascites-derived exosomes of ovarian carcinoma patients contain CD24 and EpCAM. GynecolOncol. 2007; 107:563-571.