Clinical utility of postmortem microcomputed tomography of the fetal heart: Diagnostic imaging vs macroscopic dissection

Ultrasound in Obstetrics and Gynecology

Volumn 47, Issue 1, 2016, Pages 58-64

  Hutchinson, J C ^a,b   Arthurs, O J ^a,b   Ashworth, M T ^b   Ramsey, A T ^c   Mifsud, W ^a,b   Lombardi, C M ^d   Sebire, N J ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

^c Nikon Metrology   (United Kingdom)

^d Nikon Metrology ^*  (Italy)

Author keywords

autopsy; congenital heart disease; histopathology; micro CT; perinatal

Indexed keywords

AUTOPSY; DIAGNOSTIC IMAGING; DISSECTION; FEMALE; FETUS HEART; HEART DEFECTS, CONGENITAL; HUMAN; MALE; MICRO-COMPUTED TOMOGRAPHY; PATHOLOGY; PREGNANCY; PROCEDURES; SECOND TRIMESTER PREGNANCY;

AUTOPSY; DISSECTION; FEMALE; FETAL HEART; HEART DEFECTS, CONGENITAL; HUMANS; MALE; PREGNANCY; PREGNANCY TRIMESTER, SECOND; X-RAY MICROTOMOGRAPHY;

EID: 84953449482     PISSN: 09607692     EISSN: 14690705     Source Type: Journal    
DOI: 10.1002/uog.15764     Document Type: Article

References (19)

1. van der Bom T, Zomer AC, Zwinderman AH, Meijboom FJ, Bouma BJ, Mulder BJ,. The changing epidemiology of congenital heart disease. Nat Rev Cardiol 2011; 8: 50-60.
2. Rasiah SV, Publicover M, Ewer AK, Khan KS, Kilby MD, Zamora J,. A systematic review of the accuracy of first-trimester ultrasound examination for detecting major congenital heart disease. Ultrasound Obstet Gynecol 2006; 28: 110-116.
3. Sonek J., First trimester ultrasonography in screening and detection of fetal anomalies. Am J Med Genet C Semin Med Genet 2007; 145C: 45-61.
4. Dickinson JE, Prime DK, Charles AK,. The role of autopsy following pregnancy termination for fetal abnormality. Aust N Z J Obstet Gynaecol 2007; 47: 445-449.
5. Gordijn SJ, Erwich JJ, Khong TY,. Value of the perinatal autopsy: critique. Pediatr Dev Pathol 2002; 5: 480-488.
6. Thayyil S, Sebire NJ, Chitty LS, Wade A, Chong W, Olsen O, Gunny RS, Offiah AC, Owens CM, Saunders DE, Scott RJ, Jones R, Norman W, Addison S, Bainbridge A, Cady EB, Vita ED, Robertson NJ, Taylor AM,; MARIAS collaborative group. Post-mortem MRI versus conventional autopsy in fetuses and children: a prospective validation study. Lancet 2013; 382: 223-233.
7. Thayyil S, Cleary JO, Sebire NJ, Scott RJ, Chong K, Gunny R, Owens CM, Olsen OE, Offiah AC, Parks HG, Chitty LS, Price AN, Yousry TA, Robertson NJ, Lythgoe MF, Taylor AM,. Postmortem examination of human fetuses: a comparison of whole-body high-field MRI at 9.4 T with conventional MRI and invasive autopsy. Lancet 2009; 374: 467-475.
8. Jawad N, Sebire NJ, Wade A, Taylor AM, Chitty LS, Arthurs OJ,. Bodyweight limits of fetal post mortem MRI at 1.5 T. Ultrasound Obstet Gynecol 2015 Jul 16. doi: 10.1002/uog.14948.
9. Matsui H, Mohun T, Gardiner HM,. Three-dimensional reconstruction imaging of the human foetal heart in the first trimester. Eur Heart J 2010; 31: 415.
10. Cannie M, Votino C, Moerman P, Vanheste R, Segers V, Van Berkel K, Hanssens M, Kang X, Cos T, Kir M, Balepa L, Divano L, Foulon W, De Mey J, Jani J,. Acceptance, reliability and confidence of diagnosis of fetal and neonatal virtuopsy compared with conventional autopsy: a prospective study. Ultrasound Obstet Gynecol 2012; 39: 659-665.
11. Heazell AEP, McLaughlin MJ, Schmidt EB, Cox P, Flenady V, Khong TY, Downe S,. A difficult conversation? The views and experiences of parents and professionals on the consent process for perinatal postmortem after stillbirth. BJOG 2012; 119: 987-997.
12. de Crespigny A, Bou-Reslan H, Nishimura MC, Phillips H, Carano RA, D'Arceuil HE,. 3D micro-CT imaging of the postmortem brain. J Neurosci Methods 2008; 171: 207-213.
13. Kim AJ, Francis R, Liu X, Devine WA, Ramirez R, Anderton SJ, Wong LY, Faruque F, Gabriel GC, Chung W, Leatherbury L, Tobita K, Lo CW,. Microcomputed tomography provides high accuracy congenital heart disease diagnosis in neonatal and fetal mice. Circ Cardiovasc Imaging 2013; 6: 551-559.
14. Degenhardt K, Wright AC, Horng D, Padmanabhan A, Epstein JA,. Rapid 3D phenotyping of cardiovascular development in mouse embryos by micro-CT with iodine staining. Circ Cardiovasc Imaging 2010; 3: 314-322.
15. Metscher BD,. MicroCT for developmental biology: a versatile tool for high-contrast 3D imaging at histological resolutions. Dev Dyn 2009; 238: 632-640.
16. Kang X, Cos T, Guizani M, Cannie MM, Segers V, Jani JC,. Parental acceptance of minimally invasive fetal and neonatal autopsy compared with conventional autopsy. Prenat Diagn 2014; 34: 1106-1110.
17. Lombardi CM, Zambelli V, Botta G, Moltrasio F, Cattoretti G, Lucchini V, Fesslova V, Cuttin MS,. Postmortem microcomputed tomography (micro-CT) of small fetuses and hearts. Ultrasound Obstet Gynecol 2014; 44: 600-609.
18. Human Tissue Act 2004. https://www.hta.gov.uk/codes-practice.
19. Norris FC, Wong MD, Greene ND, Scambler PJ, Weaver T, Weninger WJ, Mohun TJ, Henkelman RM, Lythgoe MF,. A coming of age: advanced imaging technologies for characterising the developing mouse. Trends Genet 2013; 29: 700-711.