Cyclooxygenase-2 and matrix metalloproteinase-9 expressions correlate with tissue inflammation degree in periodontal disease

Romanian Journal of Morphology and Embryology

Volumn 56, Issue 4, 2015, Pages 1441-1446

  Lazăr, Luminiţa ^a   Loghin, Andrada ^a   Bud, Eugen Silviu ^a   Cerghizan, Diana ^a   Horváth, Emőke ^a   Nagy, Előd Ernő ^a  

^a UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Chronic periodontitis; Cyclooxygenase 2; Gingivitis; Matrix metalloproteinase 9

Indexed keywords

BIOLOGICAL MARKER; CYCLOOXYGENASE 2; GELATINASE B;

ADULT; AGED; BIOPSY; CYTOPLASM; ENZYMOLOGY; GINGIVA; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INFLAMMATION; METABOLISM; MIDDLE AGED; MUCOSA; PATHOLOGY; PERIODONTAL DISEASE; YOUNG ADULT;

ADULT; AGED; BIOMARKERS; BIOPSY; CYCLOOXYGENASE 2; CYTOPLASM; GINGIVA; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPHENOTYPING; INFLAMMATION; MATRIX METALLOPROTEINASE 9; MIDDLE AGED; MUCOUS MEMBRANE; PERIODONTAL DISEASES; YOUNG ADULT;

EID: 84953401415     PISSN: 12200522     EISSN: 20668279     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Loo WT, Wang M, Jin LJ, Cheung MN, Li GR. Association of matrix metalloproteinase (MMP-1, MMP-3 and MMP-9) and cyclooxygenase-2 gene polymorphisms and their proteins with chronic periodontitis. Arch Oral Biol, 2011, 56(10):1081-1090.
2. Zhang F, Engebretson SP, Morton RS, Cavanaugh PF Jr, Subbaramaiah K, Dannenberg AJ. The overexpression of cyclooxygenase-2 in chronic periodontitis. J Am Dent Assoc, 2003, 134(7):861-7.
3. Tipton DA, Flynn JC, Stein SH, Dabbous MK. Cyclooxygenase-2 inhibitors decrease interleukin-1beta-stimulated prostaglandin E2 and IL-6 production by human gingival fibroblasts. J Periodontol, 2003, 74(12):1754-1763.
4. Jotwani R, Eswaran SVK, Moonga S, Cutler CW. MMP-9/TIMP-1 imbalance induced in human dendritic cells by Porphyromonas gingivalis. FEMS Immunol Med Microbiol, 2010, 58(3):314-321.
5. Amălinei C, Căruntu ID, Bălan RA. Biology of metalloproteinases. Rom J Morphol Embryol, 2007, 48(4):323-334.
6. Ii M, Yamamoto H, Adachi Y, Maruyama Y, Shinomura Y. Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis. Exp Biol Med (Maywood), 2006, 231(1):20-27.
7. Davidson B, Goldberg I, Kopolovic J, Lerner-Geva L, Gotlieb WH, Weis B, Ben-Baruch G, Reich R. Expression of matrix metalloproteinase-9 in squamous cell carcinoma of the uterine cervix - clinicopathologic study using immunohistochemistry and mRNA in situ hybridization. Gynecol Oncol, 1999, 72(3):380-386.
8. Kurzepa J, Mądro A, Czechowska G, Kurzepa J, Celiński K, Kazmierak W, Slomka M. Role of MMP-2 and MMP-9 and their natural inhibitors in liver fibrosis, chronic pancreatitis and non-specific inflammatory bowel diseases. Hepatobiliary Pancreat Dis Int, 2014, 13(6):570-579.
9. Amălinei C, Căruntu ID, Giuşcă SE, Bălan RA. Matrix metalloproteinases involvement in pathologic conditions. Rom J Morphol Embryol, 2010, 51(2):215-228.
10. Li G, Yue Y, Tian Y, Li JL, Wang M, Liang H, Liao P, Loo WT, Cheung MN, Chow LW. Association of matrix metalloproteinase (MMP)-1, 3, 9, interleukin (IL)-2, 8 and cyclooxygenase (COX)-2 gene polymorphisms with chronic periodontitis in a Chinese population. Cytokine, 2012, 60(2):552-560.
11. Bath-Balogh M, Fehrenbach MJ. Illustrated dental embryology, histology and anatomy. 3rd edition, Elsevier Saunders, 2010.
12. Newman MG, Takei H, Klokkevold PR, Carranza FA. Carranza’s clinical periodontology. 11th edition, Elsevier-Saunders, 2012.
13. Şurlin P, Rauten AM, Pirici D, Oprea B, Mogoantă L, Camen A. Collagen IV and MMP-9 expression in hypertrophic gingival during orthodontic treatment. Rom J Morphol Embryol, 2012, 53(1):161-165.
14. Mesa F, Aguilar M, Galindo-Moreno P, Bravo M, O’Valle F. Cyclooxygenase-2 expression in gingival biopsies from periodontal patients is correlated with connective tissue loss. J Periodontol, 2012, 83(12):1538-1545.
15. Smith PC, Muñoz VC, Collados L, Oyarzún AD. In situ detection of matrix metalloproteinase-9 (MMP-9) in gingival epithelium in human periodontal disease. J Periodontal Res, 2004, 39(2):87-92.
16. Schaefer AS, Richter GM, Nothnagel M, Laine ML, Noack B, Glas J, Schrezenmeir J, Groessner-Schreiber B, Jepsen S, Loos BG, Schreiber S. COX-2 is associated with periodontitis in Europeans. J Dent Res, 2010, 89(4):384-388.
17. Morton RS, Dongari-Bagtzoglou AI. Cyclooxygenase-2 is upregulated in inflamed gingival tissues. J Periodontol, 2001, 72(4):461-9.
18. Şurlin P, Oprea B, Solomon SM, Popa SG, Moţa M, Mateescu GO, Rauten AM, Popescu DM, Dragomir LP, Puiu I, Bogdan M, Popescu MR. Matrix metalloproteinase -7, -8, -9 and -13 in gingival tissue of patients with type 1 diabetes and periodontitis. Rom J Morphol Embryol, 2014, 55(Suppl 3):1137-1141.
19. Tervahartiala T, Pirilä E, Ceponis A, Maisi P, Salo T, Tuter G, Kallio P, Törnwall J, Srinivas R, Konttinen YT, Sorsa T. The in vivo expression of the collagenolytic matrix metalloproteinases (MMP-2, -8, -13, and -14) and matrilysin (MMP-7) in adult and localized juvenile periodontitis. J Dent Res, 2000, 79(12):1969-1977.
20. Ramamurthy NS, Xu JW, Bird J, Baxter A, Bhogal R, Wills R, Watson B, Owen D, Wolff M, Greenwald RA. Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease. J Periodontal Res, 2002, 37(1):1-7.
21. Brown DL, Desai KK, Vakili BA, Nouneh C, Lee HM, Golub LM. Clinical and biochemical results of the metalloproteinase inhibition with subantimicrobial doses of doxycycline to prevent acute coronary syndromes (MIDAS) pilot trial. Arterioscler Thromb Vasc Biol, 2004, 24(4):733-738.
22. Vardar-Sengul S, Buduneli E, Turkoglu O, Buduneli N, Atilla G, Wahlgren J, Sorsa T, Baylas H. The effects of selective COX-2 inhibitor/celecoxib and omega-3 fatty acid on matrix metalloproteinases, TIMP-1, and laminin-5gamma2-chain immunolocalization in experimental periodontitis. J Periodontol, 2008, 79(10):1934-1941.
23. Tilakaratne A, Soory M. Anti-inflammatory actions of adjunctive tetracyclines and other agents in periodontitis and associated comorbidities. Open Dent J, 2014, 8:109-124.
24. Yen CA, Damoulis PD, Stark PC, Hibberd PL, Singh M, Papas AS. The effect of a selective cyclooxygenase-2 inhibitor (celecoxib) on chronic periodontitis. J Periodontol, 2008, 79(1):104-113.