Sitagliptin use and risk of acute pancreatitis in type 2 diabetes mellitus: A population-based case-control study in Taiwan

European Journal of Internal Medicine

Volumn 27, Issue , 2016, Pages 76-79

  Liao, Kuan Fu ^a,b,c   Lin, Cheng Li ^d,e   Lai, Shih Wei ^d,e   Chen, Wen Chi ^c,e  

^a TZU CHI UNIVERSITY   (Taiwan)

^b BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Acute pancreatitis; Sitagliptin; Taiwan National Health Insurance Program

Indexed keywords

SITAGLIPTIN; ANTIDIABETIC AGENT;

ACUTE PANCREATITIS; ADULT; AGE; AGED; ARTICLE; CONTROLLED STUDY; DRUG HALF LIFE; ELIMINATION HALF-LIFE; FEMALE; HUMAN; ICD-9; KIDNEY FUNCTION; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; POPULATION BASED CASE CONTROL STUDY; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; SEX; TABLET; TAIWAN; ACUTE DISEASE; CASE CONTROL STUDY; COMORBIDITY; COMPLICATION; DIABETES MELLITUS, TYPE 2; FACTUAL DATABASE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PANCREATITIS; STATISTICAL MODEL; VERY ELDERLY; YOUNG ADULT;

ACUTE DISEASE; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COMORBIDITY; DATABASES, FACTUAL; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; ODDS RATIO; PANCREATITIS; RISK FACTORS; SITAGLIPTIN PHOSPHATE; TAIWAN; YOUNG ADULT;

EID: 84953367034     PISSN: 09536205     EISSN: 18790828     Source Type: Journal    
DOI: 10.1016/j.ejim.2015.09.015     Document Type: Article

References (28)

1. D. Williams-Herman, E. Round, A.S. Swern, and et al. Safety and tolerability of sitagliptin in patients with type 2 diabetes: a pooled analysis BMC Endocr Disord 8 2008 14
2. T. Karagiannis, P. Boura, and A. Tsapas Safety of dipeptidyl peptidase 4 inhibitors: a perspective review Ther Adv Drug Saf 5 2014 138 146
3. L.-Y. Tsai, W.-Y. Ma, T.-L. Hsia, D. Pei, and C.-C. Su Sitagliptin-asso-ciated acute pancreatitis: a case report J Intern Med Taiwan 22 2011 278 282
4. S.N. Iyer, A.J. Drake 3rd, R.L. West, C.E. Mendez, and R.J. Tanenberg Case report of acute necrotizing pancreatitis associated with combination treatment of sitagliptin and exenatide Endocr Pract 18 2012 e10 e13
5. eHealthMe study from FDA and social media reports. Review: could sitagliptin phosphate cause acute pancreatitis? http://www.ehealthme.com/print/ds48406887 [cited in 2014 november]
6. National Health Insurance Research Database. Taiwan http://nhird.nhri.org.tw/en/index.htm [cited in 2015 September] [English version]
7. S.W. Lai, K.F. Liao, C.C. Liao, C.H. Muo, C.S. Liu, and F.C. Sung Polypharmacy correlates with increased risk for hip fracture in the elderly: a population-based study Medicine (Baltimore) 89 2010 295 299
8. S.W. Lai, P.C. Chen, K.F. Liao, C.H. Muo, C.C. Lin, and F.C. Sung Risk of hepatocellular carcinoma in diabetic patients and risk reduction associated with anti-diabetic therapy: a population-based cohort study Am J Gastroenterol 107 2012 46 52
9. K.F. Liao, S.W. Lai, C.I. Li, and W.C. Chen Diabetes mellitus correlates with increased risk of pancreatic cancer: a population-based cohort study in Taiwan J Gastroenterol Hepatol 27 2012 709 713
10. G.A. Herman, C. Stevens, K. Van Dyck, A. Bergman, B. Yi, M. De Smet, and et al. Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses Clin Pharmacol Ther 78 2005 675 688
11. A.J. Scheen Pharmacokinetics of dipeptidylpeptidase-4 inhibitors Diabetes Obes Metab 12 2010 648 658
12. D.D. Dore, J.D. Seeger, and Chan K. Arnold Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide Curr Med Res Opin 25 2009 1019 1027
13. R. Garg, W. Chen, and M. Pendergrass Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis Diabetes Care 33 2010 2349 2354
14. S.S. Engel, D.E. Williams-Herman, G.T. Golm, R.J. Clay, S.V. Machotka, K.D. Kaufman, and et al. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis Int J Clin Pract 64 2010 984 990
15. D.T. Eurich, S. Simpson, A. Senthilselvan, C.V. Asche, J.K. Sandhu-Minhas, and F.A. McAlister Comparative safety and effectiveness of sitagliptin in patients with type 2 diabetes: retrospective population based cohort study BMJ 346 2013 f2267
16. J.L. Faillie, L. Azoulay, V. Patenaude, D. Hillaire-Buys, and S. Suissa Incretin based drugs and risk of acute pancreatitis in patients with type 2 diabetes: cohort study BMJ 348 2014 g2780
17. C.B. Giorda, R. Picariello, E. Nada, B. Tartaglino, L. Marafetti, G. Costa, and et al. Incretin therapies and risk of hospital admission for acute pancreatitis in an unselected population of European patients with type 2 diabetes: a case-control study Lancet Diabetes Endocrinol 2 2014 111 115
18. L. Li, J. Shen, M.M. Bala, J.W. Busse, S. Ebrahim, P.O. Vandvik, and et al. Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies BMJ 348 2014 g2366
19. M. Monami, I. Dicembrini, and E. Mannucci Dipeptidyl peptidase-4 inhibitors and pancreatitis risk: a meta-analysis of randomized clinical trials Diabetes Obes Metab 16 2014 48 56
20. J.B. Green, M.A. Bethel, P.W. Armstrong, J.B. Buse, S.S. Engel, J. Garg, and et al. Effect of sitagliptin on cardiovascular outcomes in Type 2 diabetes N Engl J Med 373 2015 232 242
21. S. Singh, H.Y. Chang, T.M. Richards, J.P. Weiner, J.M. Clark, and J.B. Segal Glucagonlike peptide 1-based therapies and risk of hospitalization for acute pancreatitis in type 2 diabetes mellitus: a population-based matched case-control study JAMA Intern Med 173 2013 534 539
22. C. Nitsche, S. Maertin, J. Scheiber, C.A. Ritter, M.M. Lerch, and J. Mayerle Drug-induced pancreatitis Curr Gastroenterol Rep 14 2012 131 138
23. S.W. Lai, K.F. Liao, C.L. Lin, and P.C. Chen Pyogenic liver abscess correlates with increased risk of acute pancreatitis: a population-based cohort study J Epidemiol 25 2015 246 253
24. S.W. Lai, H.C. Lai, C.L. Lin, K.F. Liao, and C.H. Tseng Chronic osteomyelitis correlates with increased risk of acute pancreatitis in a case-control study in Taiwan Eur J Intern Med 26 2015 429 432
25. A.W. Hsing, and J.P. Ioannidis Nationwide population science: lessons from the Taiwan National Health Insurance Research Database JAMA Intern Med 175 2015 1527 1529
26. S.W. Lai, C.H. Muo, K.F. Liao, F.C. Sung, and P.C. Chen Risk of acute pancreatitis in type 2 diabetes and risk reduction on anti-diabetic drugs: a population-based cohort study in Taiwan Am J Gastroenterol 106 2011 1697 1704
27. S.W. Lai, C.L. Lin, K.F. Liao, and C.Y. Lin Amiodarone use and risk of acute pancreatitis: a population-based case-control study Heart Rhythm 12 2015 163 166
28. S.W. Lai, C.L. Lin, and K.F. Liao Actively using clopidogrel correlates with an increased risk of acute pancreatitis in Taiwan Int J Cardiol 183 2015 263 266